生物活性

• 描述Dapsone, an antibiotic drug which is the principal in a multidrug regimen for the treatment of leprosy, is a sulfone with anti-inflammatory and antioxidant immunosuppressive properties^[3]. Dapsone is a potent anti-inflammatory and anti-parasitic compound, which is metabolised by cytochrome P-450 to hydroxylamines, which in turn cause methaemoglobinaemia and haemolysis^[4]. Dapsone is useful in the treatment of a number of inflammatory conditions which are characterized by neutrophil infiltration. It is the drug of choice for suppression of the symptoms of dermatitis herpetiformis, as it inhibits the process by which neutrophils leave the circulation and migrate to lesional sites^[5]. Dapsone antagonized all of the I/R (ischemia-reperfusion) end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, anti-inflammatory, and anti-apoptotic effects^[1]. Dapsone exerts cardioprotective effects on doxorubicin-induced cardiotoxicity through its anti-inflammatory and antioxidant mechanism^[3].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00141037	Kidney Diseases ... more >> Kidney Transplantation Kidney Transplant Renal Transplantation Renal Transplant Collapse <<	Phase 1 Phase 2	Completed	-	United States, Alabama ... more >> University of Alabama - Pediatric Nephrology Birmingham, Alabama, United States, 35233 United States, California Maxine Dunitz Children's Health Center Cedars-Sinai Los Angeles, California, United States, 90048 UCLA - Department of Pediatrics, Division of Nephrology Los Angeles, California, United States, 90095-1752 Stanford University Medical Center, Lucile Packard Children's Hospital Palo Alto, California, United States, 94304 UCSF Children's Hospital San Francisco, California, United States, 94143 United States, Florida University of Florida - Pediatric Nephrology Gainesville, Florida, United States, 32610-0296 United States, Louisiana Children's Hospital of New Orleans-Department of Pediatric Nephrology New Orleans, Louisiana, United States, 70118 United States, Massachusetts Children's Hospital Boston - Division of Nephrology Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Medical Center, C.S. Mott Children's Hospital- Division of Nephrology & Transplantation Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospital - Department of Nephrology Kansas City, Missouri, United States, 64108 United States, Pennsylvania The Children's Hospital of Philadelphia-Department of Nephrology Philadelphia, Pennsylvania, United States, 19104 United States, Washington Children's Hospital & Regional Medical Center - Division of Nephrology Seattle, Washington, United States, 98105 Collapse <<
  NCT00141037	-	-	Completed	-	-
  NCT02366884	Neoplasms	Phase 2	Enrolling by invitation	December 31, 2020	United States, Maryland ... more >> Atavistic Chemotherapy Clinical Trial Bethesda, Maryland, United States, 20814 Mexico Dr. Frank Arguello Cancer Clinic San Jose del Cabo, Baja California Sur, Mexico Instituto de Ciencia y Medicina Genomica Torreon, Coahuila, Mexico Collapse <<

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• 参考文献

• [1] Diaz-Ruiz A, Zavala C, Montes S, et al. Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res. 2008;86(15):3410–3419

  [2] Roy B, Das RK. Cytogenetic effect of dapsone, an antileprotic drug, in the mouse in vivo system. Int J Lepr Other Mycobact Dis. 1988 Dec;56(4):574-9.

  [3] Sheibani M, Nezamoleslami S, Faghir-Ghanesefat H, Emami AH, Dehpour AR. Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats. Cancer Chemother Pharmacol. 2020;85(3):563–571

  [4] Coleman MD. Dapsone toxicity: some current perspectives. Gen Pharmacol. 1995;26(7):1461–1467

  [5] Coleman MD. Dapsone: modes of action, toxicity and possible strategies for increasing patient tolerance. Br J Dermatol. 1993;129(5):507–513

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