|4-((6-氨基-5-溴-2-((4-氰基苯基)氨基)嘧啶-4-基)氧基)-3,5-二甲基苯甲腈|CsnPharm

CAS No.: 269055-15-4

依曲韦林 Catalog No. CSN12726

Synonyms: R165335;TMC125;依曲韦林

Etravirine is an inhibitor of non-nucleoside reverse transcriptase used to treat HIV.

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生物活性

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技术信息

生物活性

描述Etravirine (TMC 125) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that demonstrates potent in vitro activity against wild-type strains of HIV type 1 (HIV-1), as well as against numerous strains resistant to available NNRTIs. Furthermore, the potential for resistance to etravirine developing appears to be lower than for first-generation NNRTIs^[3]. Etravirine is used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS)^[4]. TMC125, was highly active against wild-type HIV-1 (EC50 = 1.4 to 4.8 nM) and showed some activity against HIV-2 (EC50 = 3.5 mM). TMC125 also inhibited a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus^[5]. Etravirine 5.2 mg/kg twice daily in treatment-experienced, HIV-1-infected children and adolescents provides comparable exposure to that in adults receiving etravirine 200 mg twice daily and is the recommended dose for children and adolescents^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02616783	HIV-1 Infection	Phase 3	Completed	-	Belgium ... more >> CHU Saint-Pierre University Hospital Brussels, Belgium University Hospital Gent Ghent, Belgium France CHU - Groupe Saint-Andre Bordeaux, France CHU de Dijon Dijon, France Hopital Europeen Marseille Marseille, France C.H.U. de Nantes Nantes, France C.H.U. de NICE Nice, France Hopital Saint Louis Paris cedex 10, France Hopital Saint Antoine Paris cedex 12, France CHU Hotel Dieu Paris, France Hopital Necker les Enfants Malades Paris, France Hopital Haut-Leveque Pessac, Cedex, France Service des Maladies Infectieuses et du Voyageur Tourcoing, France Italy Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Italy Busto Arsizio Hospital Busto Arsizio, Italy IRCCS A.O.U. San Martino Genova, Italy Azienda Ospedaliera Luigi Sacco Milano, Italy Azienda Ospedaliero Universitaria Policlinico di Modena Modena, Italy U.O. Malattie Infettive Pescara, Italy Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S. Roma, Italy Azienda Ospedaliero Universitaria di Sassari Sassari, Italy Dipartimento di Malattie Infettive e Tropicali Torino, Italy Spain Hospital Clinic de Barcelona Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Universitari Germans Trias i Pujol Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital 12 de Octubre Madrid, Spain Hospital General Universitario Gregorio Maranon Madrid, Spain Hospital Universitario La Paz Madrid, Spain Ramon Y Cajal University Hospital Madrid, Spain Hospital Costa Del Sol Marbella, Spain Hospital General Universitario de Valencia Valencia, Spain United Kingdom Royal Victoria Hospital Belfast, United Kingdom Mortimer Market Centre London, United Kingdom Newcastle Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom Collapse <<
NCT00708162	HIV Infection	Phase 3	Completed	-	-
NCT00708162	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2974 mL
- 11.4869 mL
- 22.9739 mL
- 5 mM
- 0.4595 mL
- 2.2974 mL
- 4.5948 mL
- 10 mM
- 0.2297 mL
- 1.1487 mL
- 2.2974 mL

技术信息

CAS号

269055-15-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H15BrN6O

运输

蓝冰

分子量

435.28

别名

R165335;TMC125;依曲韦林

溶解度

DMSO	42.0 mg/mL (96.5 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02616783	HIV-1 Infection	Phase 3	Completed	-	Belgium ... more >> CHU Saint-Pierre University Hospital Brussels, Belgium University Hospital Gent Ghent, Belgium France CHU - Groupe Saint-Andre Bordeaux, France CHU de Dijon Dijon, France Hopital Europeen Marseille Marseille, France C.H.U. de Nantes Nantes, France C.H.U. de NICE Nice, France Hopital Saint Louis Paris cedex 10, France Hopital Saint Antoine Paris cedex 12, France CHU Hotel Dieu Paris, France Hopital Necker les Enfants Malades Paris, France Hopital Haut-Leveque Pessac, Cedex, France Service des Maladies Infectieuses et du Voyageur Tourcoing, France Italy Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Italy Busto Arsizio Hospital Busto Arsizio, Italy IRCCS A.O.U. San Martino Genova, Italy Azienda Ospedaliera Luigi Sacco Milano, Italy Azienda Ospedaliero Universitaria Policlinico di Modena Modena, Italy U.O. Malattie Infettive Pescara, Italy Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S. Roma, Italy Azienda Ospedaliero Universitaria di Sassari Sassari, Italy Dipartimento di Malattie Infettive e Tropicali Torino, Italy Spain Hospital Clinic de Barcelona Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Universitari Germans Trias i Pujol Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital 12 de Octubre Madrid, Spain Hospital General Universitario Gregorio Maranon Madrid, Spain Hospital Universitario La Paz Madrid, Spain Ramon Y Cajal University Hospital Madrid, Spain Hospital Costa Del Sol Marbella, Spain Hospital General Universitario de Valencia Valencia, Spain United Kingdom Royal Victoria Hospital Belfast, United Kingdom Mortimer Market Centre London, United Kingdom Newcastle Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom Collapse <<
NCT00708162	HIV Infection	Phase 3	Completed	-	-
NCT00708162	-	-	Completed	-	-
NCT00850395	-	-	Completed	-	-
NCT01076179	-	-	Completed	-	-
NCT00850395	-	-	Completed	-	-
NCT02016924	Acquired Immune Deficiency Syn... more >>drome (AIDS) HIV Infections Collapse <<	Phase 2 Phase 3	Recruiting	December 2024	United States, California ... more >> Pediatric Infectious Diseases Associate Recruiting Long Beach, California, United States, 90806 Principal Investigator: Jagmohan Batra, MD Children's Hospital Los Angeles Withdrawn Los Angeles, California, United States, 90027 United States, Colorado Children's Hospital Colorado Recruiting Aurora, Colorado, United States, 80045 Principal Investigator: Elizabeth McFarland, MD United States, District of Columbia Children's National Medical Center Recruiting Washington, District of Columbia, United States, 20852 Principal Investigator: Natella Rakhmanina United States, Florida University of South Florida Clinic at Children's Medical Services Recruiting Tampa, Florida, United States, 33620 Principal Investigator: Carina Rodriguez, MD United States, Georgia Emory-Children's Center- Ponce Family and Youth Clinic Completed Atlanta, Georgia, United States, 30308 United States, Massachusetts Boston Medical Center Withdrawn Boston, Massachusetts, United States, 02118 United States, New York Bellevue Hospital Recruiting New York, New York, United States, 10016 Principal Investigator: William Borkowsky, MD SUNY Upstate Medical University Recruiting Syracuse, New York, United States, 13210 Principal Investigator: Leonard Weiner, MD United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Principal Investigator: Aditya Gaur, MD United States, Texas University of Texas Health Science Center of Houston Recruiting Houston, Texas, United States, 77030 Principal Investigator: Gloria Heresi, MD Argentina Hospital General de Agudos Dr. Cosme Argerich Recruiting Buenos Aires, Argentina, 1151 Principal Investigator: Diego Cecchini Helios Salud S.A. Recruiting Buenos Aires, Argentina, C1131ACG Principal Investigator: Maria R Bologna Hospital Ramos Mejía Recruiting Buenos Aires, Argentina, C1221ADC DF Principal Investigator: Irene Foradori Fundacion Huesped Recruiting Buenos Aires, Argentina Principal Investigator: Pedro Cahn Thailand Siriraj Hospital Mahidol University Recruiting Bangkok, Krung Thep Maha Nakhon, Thailand Principal Investigator: Kulkanya Chokephaibulkit The HIV NAT Research Collaboration Recruiting Bangkok, Krung Thep Maha Nakhon, Thailand Principal Investigator: Sivaporn Getechompol Srinagarind Hospital Khon Kaen University Recruiting Khon Kaen, Thailand Principal Investigator: Pope Kosalaraksa Collapse <<
NCT01076179	-	-	Completed	-	-
NCT02302547	HIV	Phase 3	Completed	-	France ... more >> Unité des Maladies Infectieuses, CHU de CAEN Caen, France, 14033 Service des Maladies Infectieuses, CHR Orléans La Source, ORLEANS CEDEX 2 CHR d'ORLEANS, France, 45067 Service d'Immunologie Clinique centre de Vaccination anti- VIH ANRS Hopital Henri- Mondor Creteil, France, 94010 Service de Médecine Interne et Maladies Infectieuses, Groupe Hospitalier La Rochelle, Cedex 01 La Rochelle, France, 17019 Service de Pneumologie, centre Hospitalier Fontenoy, CH de CHARTRES Le Coudray, France, 28630 CHU de NANCY Nancy, France, 54035 Service des maladies Infectieuses et tropicales, CH GEORGES RENON Niort, France, 79021 Service des Maladies Infectieuses et tropicales, APHP SAINT LOUIS Paris, France, 75475 Hospital Tenon Paris, France, 75970 Centre de diagnostic et thérapeutique, Hopital Hotel Dieu Paris, France, 94010 Consultation Maladies Infectieuses, Chu de Poitiers, Cedex Poitiers, France, 86021 Maladies Infectieuses, CHU de ROUEN Rouen, France, 76031 Service de Médecine Interne, CH de SAINTONGE- BP 326 Saintes, France, 17108 Médecine Interne, Hôpital FOCH Suresnes, France, 92151 Service Universitaire des Maladies Infectieuses et du Voyageur, CH DRON Tourcoing, France, 59200 Service de Medecine Interne et Maladies Infectieuses, CHRU BRETONNEAU, TOURS CEDEX9 Tours, France, 37044 Collapse <<
NCT02157311	HIV-1 Infection	Phase 3	Completed	-	France ... more >> Hôpital Meynard Fort-de-france, Martinique, France, 97261 Hôpital Avicenne Bobigny, France, 93000 CHU Côte de Nacre Caen, France, 14033 Centre Hospitalier Sud Francilien Corbeil Essonnes, France, 91100 Hôpital Le Bocage Dijon, France, 21079 Hôpital Raymond Poincaré Garches, France, 92380 Hôpital Bicêtre Kremlin Bicetre, France, 94275 Hôpital Gui de Chauliac Montpellier, France, 34295 Hôpital Saint-Antoine Paris, France, 75012 Hôpital Pitié-Salpêtrière Paris, France, 75013 Hôpital Européen Georges Pompidou Paris, France, 75015 Hôpital Necker Paris, France, 75015 Hôpital Bichat Paris, France, 75018 Hôpital Tenon Paris, France, 75020 Hôpital Foch Suresnes, France, 92151 Hôpital Purpan Toulouse, France, 31059 Hôpital Bretonneau Tours, France, 37044 Collapse <<
NCT02605954	-	-	Completed	-	-
NCT02605954	HIV-1 Infection	Phase 3	Completed	-	-
NCT01814722	-	-	Terminated(The trial was termi... more >>nated early due to slow recruitment.) Collapse <<	-	-
NCT00537394	HIV Infections	Phase 3	Completed	-	-
NCT00381303	HIV Infectiou... more >>s Collapse <<	Phase 3	Completed	-	-
NCT01814722	-	-	Terminated(The trial was termi... more >>nated early due to slow recruitment.) Collapse <<	-	-
NCT00381303	-	-	Completed	-	-
NCT01189695	HIV AIDS ... more >> Lopinavir Treatment Failure Collapse <<	Phase 4	Completed	-	Thailand ... more >> Bamrasnaradura Infectious Diseases Institute Nonthaburi, Thailand, 11000 Collapse <<
NCT00751530	-	-	Completed	-	-
NCT00537394	-	-	Completed	-	-
NCT00751530	-	-	Completed	-	United States, California ... more >> Light Source Medical Los Angeles, California, United States, 900036 AIDS Healthcare Foundation Los Angeles, California, United States, 90028 Synergy Hematology and Oncology Los Angeles, California, United States, 90036 Quest Clinical Research San Francisco, California, United States, 94115 United States, Connecticut Connecticut Health Care Group Glastonbury, Connecticut, United States, 06033 United States, District of Columbia Dupont Circle Physicians Group Washington, D.C., District of Columbia, United States, 20009 Capital Medical Associates PC Washington, D.C., District of Columbia, United States, 20036 United States, Florida Orlando Immunology Center Orlando, Florida, United States, 32803 United States, Illinois Ruth M. Rothstein CORE Center Chicago, Illinois, United States, 60612 United States, Massachusetts Community Research Initiative Boston, Massachusetts, United States, 02215 Community Research Initiative - West Springfield, Massachusetts, United States, 01107 United States, New York Infectious Diseases and HIV Medicine Immunodeficiency Clinic Buffalo, New York, United States, 14215 Bellman, MD New York, New York, United States, 10003 United States, Pennsylvania Mounzer, MD Philadelphia, Pennsylvania, United States, 19107 United States, Texas Dr. Nicholaos C. Bellos & Associates Dallas, Texas, United States, 75204 Collapse <<
NCT01500616	Hepatitis C, Chronic	Phase 3	Completed	-	Belgium ... more >> Antwerpen, Belgium Brussel, Belgium Bruxelles, Belgium Charleroi, Belgium Gent, Belgium Leuven, Belgium Liège, Belgium Germany Berlin, Germany Bonn, Germany Dortmund, Germany Frankfurt, Germany Hannover, Germany Köln, Germany Stuttgart, Germany Tübingen, Germany Hungary Budapest, Hungary Ireland Dublin, Ireland Luxembourg Luxembourg, Luxembourg Portugal Amadora, Portugal Lisboa, Portugal Lisbon, Portugal Porto, Portugal Russian Federation Perm, Russian Federation Saint-Petersburg, Russian Federation St Petersburg, Russian Federation Toliatti, Russian Federation Volgograd, Russian Federation Yoshkar - Ola, Russian Federation United Kingdom Glasgow, United Kingdom Liverpool, United Kingdom London, United Kingdom Plymouth, United Kingdom Collapse <<
NCT01276236	Kaposi's Sarcoma	Not Applicable	Unknown	April 2015	United States, California ... more >> San Francisco General Hospital, Clinical Trials Unit San Francisco, California, United States, 94110 Collapse <<
NCT01458132	Infection, Human Immunodeficie... more >>ncy Virus Collapse <<	Not Applicable	Completed	-	-
NCT01428986	-	-	Completed	-	Japan ... more >> National Center for Global Health and Medicine Shinjuku, Tokyo, Japan, 1628655 Collapse <<
NCT03256422	HIV Infections	Phase 3	Active, not recruiting	December 2020	-
NCT01098526	Infections, Human Immunodefici... more >>ency Virus and Herpesviridae Collapse <<	Phase 1	Completed	-	United States, New York ... more >> GSK Investigational Site Buffalo, New York, United States, 14202 Collapse <<
NCT00042289	HIV Infections	Phase 4	Recruiting	September 30, 2019	-
NCT01908660	-	-	Completed	-	Spain ... more >> Hospital Universitario de Valme Seville, Spain, 41014 Collapse <<
NCT01641367	HIV-1 Infection	Phase 4	Active, not recruiting	December 2018	Brazil ... more >> Hospital Nossa Senhora da Conceicao CRS (12201) Porto Alegre, RS, Brazil, 9043010 Instituto de Pesquisa Clinica Evandro Chagas (12101) Rio de Janeiro, Brazil, 21045 Haiti Les Centres GHESKIO CRS (30022) Port-au-Prince, Bicentaire, Haiti, HT-6110 GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS Port Au Prince, Haiti India BJ Medical College CRS (31441) Pune, Maharashtra, India, 411001 Chennai Antiviral Research and Treatment (CART) CRS (11701) Chennai, Taramani, India, 600113 Kenya AMPATH at Moi Univ. Teaching Hosp. Eldoret CRS (12601) Eldoret, Kenya, 30100 Kenya Medical Research Institute/Center for Disease Control (KEMRI/CDC) CRS (31460) Kisumu, Kenya, 40100 Malawi Malawi CRS (12001) Lilongwe, Malawi Peru San Miguel CRS (11302) San Miguel, Lima, Peru Barranco CRS (11301) Lima, Peru, 18 PE South Africa University of the Witwatersrand Helen Joseph (WITS HJH) CRS (11101) Johannesburg, Gauteng, South Africa, 2193 Family Clinical Research Unit (FAM-CUR) CRS (8950) Cape Town, West Cape, South Africa, 7505 Durban Adult HIV CRS (11201) Durban, South Africa, 4013 SF Soweto ACTG CRS (12301) Johannesburg, South Africa Thailand 31802 Thai Red Cross AIDS Research Centre (TRC-ARC) CRS Bangkok, Patumwan, Thailand, 10330 31784 Chiang Mai University HIV Treatment CRS Chiang Mai, Thailand, 50200 Uganda JCRC CRS Kampala, Uganda Zimbabwe UZ-Parirenyatwa CRS (30313) Harare, Zimbabwe Collapse <<
NCT01254656	HIV-1	Phase 2	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	Australia, New South Wales ... more >> Pfizer Investigational Site Darlinghurst, New South Wales, Australia, 2010 Australia, Victoria Pfizer Investigational Site Melbourne, Victoria, Australia, 3004 Brazil Pfizer Investigational Site Nova Iguacu, RJ, Brazil, 26030-381 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 1K2 Canada, Quebec Pfizer Investigational Site Montreal, Quebec, Canada, H2L 4P9 Pfizer Investigational Site Montreal, Quebec, Canada, H2L 5B1 Italy Pfizer Investigational Site Milano, Italy, 20127 Pfizer Investigational Site Torino, Italy, 10149 Mexico Pfizer Investigational Site Mexico, Distrito Federal, Mexico, 14050 Poland Pfizer Investigational Site Bydgoszcz, Poland, 85-030 Pfizer Investigational Site Warszawa, Poland, 01-201 South Africa Pfizer Investigational Site Johannesburg, Gauteng, South Africa, 2193 Pfizer Investigational Site Pretoria, Gauteng, South Africa, 0083 Pfizer Investigational Site Soweto, Gauteng, South Africa, 2013 Pfizer Investigational Site Durban, Kwazulu-Natal, South Africa, 4001 Pfizer Investigational Site Cape Town, Western Cape, South Africa, 7925 Pfizer Investigational Site Pretoria, South Africa, 0083 Switzerland Pfizer Investigational Site Lugano, Switzerland, 6903 Pfizer Investigational Site St. Gallen, Switzerland, 9007 Pfizer Investigational Site Zuerich, Switzerland, 8091 United Kingdom Pfizer Investigational Site Brighton, East Sussex, United Kingdom, BN2 1ES Pfizer Investigational Site London, United Kingdom, NW3 2QG Pfizer Investigational Site London, United Kingdom, SW10 9NH Collapse <<
NCT01254656	-	-	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	-
NCT01225406	-	-	Completed	-	Thailand ... more >> Chulalongkorn University Bangkok, Thailand, 10330 HIV-NAT Bangkok, Thailand, 10330 Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 Prapokklao Chantaburi Chantaburi, Thailand, 22000 Nakornping Hospital Chiang Mai, Thailand, 50180 Chiang Rai Regional Hospital Chiang Rai, Thailand, 57000 Khon Kaen University Khon Kaen, Thailand, 40002 Bamrasnaradura Institute Nonthaburi, Thailand, 11000 Surin Hospital Surin, Thailand, 32000 Collapse <<
NCT01641367	-	-	Active, not recruiting	-	-
NCT00624195	HIV Infections	Phase 2 Phase 3	Completed	-	United States, California ... more >> HIV Neurobehavioral Research Center, University of California San Diego San Diego, California, United States, 92103 University of California, San Francisco San Francisco, California, United States, 94110 United States, Maryland Johns Hopkins University- School of Medicine Baltimore, Maryland, United States, 21287 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, New York Mount Sinai Medical Center New York, New York, United States, 10024 Collapse <<
NCT00884793	HIV Infections	Not Applicable	Completed	-	United States, California ... more >> San Francisco General Hospital San Francisco, California, United States, 94110 San Francisco VA Medical Center (SFVAMC) San Francisco, California, United States, 94121 Collapse <<
NCT00884793	-	-	Completed	-	-
NCT00977756	-	-	Completed	-	-
NCT00624195	-	-	Completed	-	-
NCT01118871	HIV HIV Infec... more >>tions Collapse <<	Phase 4	Terminated	-	United Kingdom ... more >> St. Mary's Hospital London, United Kingdom, W2 1NY Collapse <<
NCT00666055	-	-	Completed	-	United States, North Carolina ... more >> The University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599-7215 Collapse <<
NCT01199731	Infection, Human Immunodeficie... more >>ncy Virus Collapse <<	Phase 2	Terminated(The study was stopp... more >>ed due to safety concerns) Collapse <<	-	-
NCT01199731	-	-	Terminated(The study was stopp... more >>ed due to safety concerns) Collapse <<	-	-
NCT00460382	HIV Infections	Phase 2	Completed	-	France ... more >> Hôpital Gustave Dron, Service Maladies Infectieuses Tourcoing, France, 59208 Collapse <<
NCT03369743	-	-	Recruiting	December 30, 2018	France ... more >> Yasmine Dudoit Recruiting Paris, France, 75013 Contact: Yasmine Dudoit 330142164181 yasmine.dudoit@aphp.fr Contact: Romain Palich, MD 33142164171 romain.palich@aphp.fr Collapse <<
NCT00460746	HIV	Phase 3	Completed	-	United States, California ... more >> Los Angeles, California, United States Collapse <<
NCT00460746	-	-	Completed	-	-
NCT00896051	HIV Infections ... more >> Acquired Immunodeficiency Syndrome Collapse <<	Phase 2	Completed	-	United States, Arkansas ... more >> Little Rock, Arkansas, United States United States, California Bakersfield, California, United States Beverly Hills, California, United States United States, Florida Orlando, Florida, United States Tampa, Florida, United States Vero Beach, Florida, United States West Palm Beach, Florida, United States United States, Georgia Macon, Georgia, United States United States, Texas Dallas, Texas, United States Houston, Texas, United States Argentina Buenos Aires, Argentina Cordoba, Argentina France Paris Cedex 10, France Paris, France Tourcoing, France South Africa Bloemfontein, South Africa Cape Town, South Africa George, South Africa Thailand Bangkok, Thailand Collapse <<
NCT00855335	HIV HIV Infec... more >>tions Pregnancy Collapse <<	Phase 3	Completed	-	United States, Florida ... more >> Daytona Beach, Florida, United States Jacksonville, Florida, United States Miami, Florida, United States Pensacola, Florida, United States Port Saint Lucie, Florida, United States West Palm Beach, Florida, United States United States, Georgia Savannah, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Springfield, Massachusetts, United States United States, Michigan Dearborn, Michigan, United States United States, New York Bronx, New York, United States Syracuse, New York, United States United States, North Carolina Chapel Hill, North Carolina, United States Greensboro, North Carolina, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Texas Bellaire, Texas, United States Puerto Rico San Juan Pr, Puerto Rico Collapse <<
NCT00896051	-	-	Completed	-	-
NCT00823979	HIV-1	Phase 2	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	-
NCT01336829	Hepatitis C H... more >>IV Collapse <<	Phase 1	Completed	-	Belgium ... more >> Antwerp, Belgium Collapse <<
NCT00534352	HIV-1 Infection	Phase 2	Completed	-	-
NCT00823979	-	-	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	-
NCT00867152	Healthy Volunteer	Phase 1	Completed	-	United States, New York ... more >> GSK Investigational Site Buffalo, New York, United States, 14202 Collapse <<
NCT00855335	-	-	Completed	-	-
NCT00412646	Anti-Retroviral Agents ... more >> HIV-1 Collapse <<	Phase 2	Completed	-	-
NCT00740389	HIV AIDS ... more >> Fungal Infection Collapse <<	Phase 1	Completed	-	-
NCT00782301	Hepatitis B H... more >>uman Immunodeficiency Virus Hepatitis C, Chronic Collapse <<	Phase 4	Withdrawn	-	United States, Florida ... more >> Pfizer Investigational Site Clearwater, Florida, United States, 33765 Pfizer Investigational Site Orlando, Florida, United States, 32803 Pfizer Investigational Site Safety Harbor, Florida, United States, 34695 Pfizer Investigational Site Wilton Manors, Florida, United States, 33305 United States, Georgia Pfizer Investigational Site Atlanta, Georgia, United States, 30308 Pfizer Investigational Site Atlanta, Georgia, United States, 30312 United States, Louisiana Pfizer Investigational Site New Orleans, Louisiana, United States, 70112 United States, Massachusetts Pfizer Investigational Site Worcester, Massachusetts, United States, 01605 Pfizer Investigational Site Worcester, Massachusetts, United States, 01655 United States, New York Pfizer Investigational Site Mt. Vernon, New York, United States, 10550 United States, Oklahoma Pfizer Investigational Site Tulsa, Oklahoma, United States, 74135 United States, Texas Pfizer Investigational Site Bellaire, Texas, United States, 77401 Pfizer Investigational Site Conroe, Texas, United States, 77301 Pfizer Investigational Site Dallas, Texas, United States, 75390 Pfizer Investigational Site Stafford, Texas, United States, 77477 Canada, British Columbia Pfizer Investigational Site Vancouver, British Columbia, Canada, V6Z 2C7 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 2N2 Poland Pfizer Investigational Site Bydgoszcz, Poland, 85-030 Collapse <<
NCT00828815	HIV Pharmacok... more >>inetics Collapse <<	Phase 1	Completed	-	-
NCT00774111	Healthy Subjects	Phase 1	Completed	-	United States, New York ... more >> GSK Investigational Site Buffalo, New York, United States, 14202 Collapse <<
NCT00225303	HIV Infection	Phase 2	Completed	-	-
NCT00359021	HIV-1	Phase 3	Completed	-	-
NCT00534352	-	-	Completed	-	-
NCT01615601	-	-	Completed	-	Canada ... more >> Vancouver, Canada Collapse <<
NCT00254046	HIV	Phase 3	Completed	-	-
NCT00359021	-	-	Completed	-	-
NCT01543035	HIV Infection	Phase 3	Completed	-	Switzerland ... more >> Universitätsspital Basel Klinik für Infektiologie & Spitalhygiene Bale, Switzerland, 4031 Inselspital PKT2B / Poliklinik für Infektiologie Berne, Switzerland, 3010 HUG /Division des Maladies infectieuses Unité VIH/SIDA Geneva, Switzerland, 1211 Hôpital Neuchâtelois - La Chaux-de-Fonds Service des Maladies infectieuses La Chaux-de-Fonds, Switzerland, 2300 CHUV / Service des maladies infectieuses Médecine 2 Lausanne, Switzerland, 1011 Kantonsspital / Infektiologie und Spitalhygiene Departement Innere Medizin St Gallen, Switzerland, 9007 Universitätsspital Zürich Division of Infectious Diseases and Hospital Epidemiology Department of Internal Medicine Zurich, Switzerland, 8091 Collapse <<
NCT00111280	HIV Infection	Phase 2	Completed	-	-
NCT00767117	HIV	Phase 1	Completed	-	-
NCT01045369	HIV Infections	Phase 4	Completed	-	United States, Texas ... more >> Therapeutic Concepts, PA Houston, Texas, United States, 77004 Collapse <<
NCT01876966	HIV	Phase 1	Completed	-	-
NCT00081978	HIV Infection	Phase 2	Completed	-	-
NCT00255099	HIV	Phase 3	Completed	-	-
NCT00792324	HIV	Phase 3	Completed	-	United Kingdom ... more >> Chelsea and Westminster Hospital London, United Kingdom, SW10 9TH Collapse <<
NCT02063360	Infection, Human Immunodeficie... more >>ncy Virus Collapse <<	Phase 1	Completed	-	-
NCT01199939	Human Immunodeficiency Virus (... more >>HIV) Collapse <<	Phase 2	Completed	-	United States, California ... more >> Long Beach, California, United States Los Angeles, California, United States San Francisco, California, United States United States, Colorado Denver, Colorado, United States United States, District of Columbia Washington, District of Columbia, United States United States, Florida Fort Pierce, Florida, United States Miami, Florida, United States Orlando, Florida, United States United States, Georgia Decatur, Georgia, United States Macon, Georgia, United States United States, Michigan Berkley, Michigan, United States United States, Missouri Saint Louis, Missouri, United States United States, New Jersey Hillsborough, New Jersey, United States Neptune, New Jersey, United States United States, New York Buffalo, New York, United States Manhasset, New York, United States United States, North Carolina Charlotte, North Carolina, United States United States, Texas Austin, Texas, United States Dallas, Texas, United States Harlingen, Texas, United States Houston, Texas, United States United States, Washington Seattle, Washington, United States Puerto Rico San Juan, Puerto Rico Collapse <<
NCT01504841	HIV Infections	Phase 1 Phase 2	Active, not recruiting	October 31, 2021	United States, Florida ... more >> Pediatric Perinatal HIV Clinical Trials Unit CRS Miami, Florida, United States, 33136 United States, Illinois Lurie Children's Hospital of Chicago (LCH) CRS Chicago, Illinois, United States, 60614-3393 United States, New York Bronx-Lebanon Hospital Center NICHD CRS Bronx, New York, United States, 10457 Jacobi Med. Ctr. Bronx NICHD CRS Bronx, New York, United States, 10461 Brazil SOM Federal University Minas Gerais Brazil NICHD CRS Belo Horizonte, Minas Gerais, Brazil, 30.130-100 Hospital Federal dos Servidores do Estado NICHD CRS Rio de Janeiro, Brazil, 20221-903 Instituto de Puericultura e Pediatria Martagao Gesteira - UFRJ NICHD CRS Rio de Janeiro, Brazil, 21941-612 Hosp. Geral De Nova Igaucu Brazil NICHD CRS Rio de Janeiro, Brazil, 26030 Univ. of Sao Paulo Brazil NICHD CRS Sao Paulo, Brazil, 14049-900 South Africa Wits RHI Shandukani Research Centre CRS Johannesburg, Gauteng, South Africa, 2001 Umlazi CRS Durban, KwaZulu-Natal, South Africa, 4001 Collapse <<
NCT01199939	-	-	Completed	-	-
NCT00128830	Human Immunodeficiency Virus T... more >>ype 1 Collapse <<	Phase 2	Completed	-	-
NCT00128830	-	-	Completed	-	-
NCT01437241	-	-	Completed	-	Spain ... more >> Hospital La Linea de la Concepción La Linea de la Concepción, Cadiz, Spain, 11300 Hospital Universitario Puerto Real Puerto Real, Cadiz, Spain, 11510 Hospital Costa del Sol Marbella, Malaga, Spain, 29600 Hospital Universitario Reina Sofía Cordoba, Spain, 14004 Hospital Universitario San Cecilio Granada, Spain, 04009 Hospital Universitario Virgen de las Nieves Granada, Spain, 18014 Hospital Ciudad de Jaén Jaen, Spain, 23001 Hospital Universitario Carlos Haya Malaga, Spain, 29010 Hospital Universitario Virgen de la Victoria Malaga, Spain, 29010 Hospital Universitario Virgen del Rocio Sevilla, Spain, 41013 Hospital Universitario Virgen de Valme Sevilla, Spain, 41014 Collapse <<
NCT00855413	Acute HIV Infection ... more >> HIV Infections Collapse <<	Phase 4	Terminated(Study halted by spo... more >>nsor due to slow enrollment.) Collapse <<	-	United States, North Carolina ... more >> The University of North Carolina - Chapel Hill Chapel Hill, North Carolina, United States, 27599 Duke University Durham, North Carolina, United States, 27707 Collapse <<
NCT00920296	Healthy Subjects ... more >> Infection, Human Immunodeficiency Virus Collapse <<	Phase 1	Completed	-	United States, Texas ... more >> GSK Investigational Site San Antonio, Texas, United States, 78217 Collapse <<
NCT00531323	HIV Infections	Phase 1	Completed	-	United Kingdom ... more >> St Stephens Centre, Chelsea & Westminster Hospital London, United Kingdom, SW10 9th Collapse <<
NCT00855413	-	-	Terminated(Study halted by spo... more >>nsor due to slow enrollment.) Collapse <<	-	-
NCT01741844	-	-	Completed	-	Korea, Republic of ... more >> Dae-Gu, Korea, Republic of Collapse <<
NCT00354627	HIV-1	Phase 3	Completed	-	-
NCT00903682	HIV Infection ... more >> HIV Acquired Immunodeficiency Syndrome Collapse <<	Phase 2	Completed	-	-
NCT00903682	-	-	Completed	-	-
NCT00792584	Sleep Disorders	Not Applicable	Completed	-	Switzerland ... more >> Geneva Hospital Geneva, Switzerland, 1211 Collapse <<
NCT01034917	HIV	Phase 3	Completed	-	Spain ... more >> Germans Trias i Pujol University Hospital Badalona, Barcelona, Spain, 08916 Collapse <<
NCT00665847	HIV-1	Phase 2	Completed	-	-
NCT00980538	HIV Infections ... more >> HIV-1 Collapse <<	Phase 3	Recruiting	January 31, 2024	-
NCT01427504	Hepatitis C H... more >>IV Collapse <<	Not Applicable	Completed	-	United States, Colorado ... more >> University of Colorado Anschutz Medical Campus Aurora, Colorado, United States, 80045 Collapse <<
NCT01121809	HIV-1 Infection ... more >> HIV Infections Collapse <<	Phase 4	Completed	-	Spain ... more >> Hospitales Universitarios Virgen del Rocio Sevilla, Spain, 41013 Collapse <<
NCT01427504	-	-	Completed	-	-
NCT00871234	-	-	Completed	-	-
NCT01625169	HIV	Not Applicable	Completed	-	United States, California ... more >> LAC+USC MCA Clinic Los Angeles, California, United States, 90033 Collapse <<
NCT00871234	Endothelial Function ... more >> Lipids Insulin Resistance Inflammation HIV Infections Collapse <<	Phase 1	Completed	-	United States, Indiana ... more >> Infectious Diseases Research Center Indianapolis, Indiana, United States, 46202 Collapse <<
NCT01625169	-	-	Completed	-	-
NCT01422330	Human Immunodeficiency Virus (... more >>HIV) Infection Collapse <<	Phase 4	Completed	-	-
NCT00855088	HIV/AIDS HIV ... more >>Infections Collapse <<	Phase 1	Completed	-	United States, North Carolina ... more >> UNC Hospitals CTRC Chapel Hill, North Carolina, United States, 27514 Collapse <<
NCT01347658	HIV	Phase 1	Completed	-	Spain ... more >> Hospital Germans Trias i Pujol Badalona, Barcelona, Spain, 08916 Collapse <<
NCT00665847	-	-	Completed	-	-
NCT02212379	HIV-1 Infection	Phase 2	Completed	-	France ... more >> Hôpital Avicenne Bobigny, France, 93000 Hôpital Jean Verdier Bondy, France, 93140 Hôpital Saint André Bordeaux, France, 33076 Hôpital Bicêtre Le Kremlin Bicêtre, France, 94275 Hôpital Croix Rousse Lyon, France, 69317 Hôpital Sainte marguerite Marseille, France, 13009 Hôpital Gui de Chauliac Montpellier, France, 34000 CHU Hôtel Dieu Nantes, France, 44093 Hôpital de l'Archet Nice, France, 06202 Hôpital Saint Louis Paris, France, 75010 Hôpital Pitié-Salpétrière Paris, France, 75013 Hôpital Cochin Paris, France, 75014 Hôpital Necker Paris, France, 75015 Hôpital Bichat Claude Bernard Paris, France, 75018 Hôpital Européen Georges Pompidou Paris, France, 75908 Hôpital Bretonneau Tours, France, 37044 Spain Hospital de Bellvitge Barcelona, Spain, 08000 Hospital de la santa Creu i San Pau Barcelona, Spain, 08025 Hospital Clinic Barcelona, Spain, 08036 Collapse <<
NCT02818348	HIV-1 Infection	Phase 1	Completed	-	Spain ... more >> Fundació Lluita contra la SIDA Badalona, Barcelona, Spain, 08916 Collapse <<
NCT01090648	HIV-Infections	Phase 1	Completed	-	-
NCT00959894	-	-	Completed	-	-
NCT00959894	HIV Infections	Phase 2	Completed	-	United States, North Carolina ... more >> The University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599-7215 Carolinas Medical Center Charlotte, North Carolina, United States, 28207 Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Collapse <<

依曲韦林 Catalog No. CSN12726

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