生物活性

• 描述Daminozide, a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03172715	Tibial Fractures	Not Applicable	Recruiting	June 2029	Finland ... more >> Central Finland Hospital Recruiting Jyväskylä, Finland, 40620 Contact: Juha Paloneva, MD, PhD    +358 14 2693119       Contact: Valtteri Tapper, MD          Sub-Investigator: Alar Toom, MD, PhD          Sub-Investigator: Valtteri Tapper, MD, PhD          Principal Investigator: Juha Paloneva, MD, PhD          Sub-Investigator: Heikki Nurmi, MD, PhD          Sub-Investigator: Maija Pesola, MD, PhD          Sub-Investigator: Konsta Pamilo, MD, PhD          Kuopio University Hospital Not yet recruiting Kuopio, Finland Contact: Jussi Jalkanen, MD          Principal Investigator: Jussi Jalkanen, MD, PhD          Sub-Investigator: Tommi Kääriäinen, MD, PhD          Päijät-Häme Central Hospital Not yet recruiting Lahti, Finland Contact: Jussi Haapala, MD, PhD          Principal Investigator: Jussi Haapala, MD, PhD          Sub-Investigator: Sami Nurmi, MD          Oulu University Hospital Not yet recruiting Oulu, Finland Contact: Tuukka Niinimäki, MD, PhD          Principal Investigator: Tuukka Niinimäki, MD, PhD          Sub-Investigator: Tero Kortekangas, MD, PhD          Seinäjoki Central Hospital Not yet recruiting Seinäjoki, Finland Contact: Janne Jousmäki, MD, PhD          Principal Investigator: Janne Jousmäki, MD, PhD          Sub-Investigator: Ville Sumuvuori, MD, PhD          Coxa Joint Replacement Hospital Not yet recruiting Tampere, Finland Contact: Jyrki Nieminen, MD          Principal Investigator: Jyrki Nieminen, MD, PhD          Tampere University Hospital Not yet recruiting Tampere, Finland Contact: Minna Laitinen, MD, PhD          Principal Investigator: Ilari Pajamäki, MD          Turku University Hospital Not yet recruiting Turku, Finland Contact: Niko Strandberg, MD, PhD          Principal Investigator: Niko Strandberg, MD, PhD          Sub-Investigator: Mika Junnila, MD, PhD Collapse <<
  NCT02188355	-	-	Recruiting	September 2019	-
  NCT02336243	Premature Birth ... more >> Preeclampsia Fetal Growth Retardation Stillbirth Collapse <<	Phase 3	Unknown	April 2018	Chile ... more >> Centro de Salud Familiar ANCORA Juan Pablo II Recruiting Santiago, Chile Contact: Francisco Arancibia, Matron          Contact    +56 2 2482 2400       Centro de Salud Familiar ANCORA Madre Teresa de Calcuta Recruiting Santiago, Chile Contact: Patricia Alar, Enf Matrona          Contact    +56 2 2851 5211       Centro de Salud Familiar ANCORA San Alberto Hurtado Recruiting Santiago, Chile Contact: Ghislaine Bustamante, Matrona          Contact    +56 2 2587 9300       Centro Medico Lira 85 Recruiting Santiago, Chile Contact: Cecilia Berrios, Enf Matrona          Contact    +56 2 2354 8077       Centro Medico San Joaquin Recruiting Santiago, Chile Contact: Veronica Nuñez, Enf Matrona          Contact    +56 2 2354 8540 Collapse <<

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• 参考文献

• [1] Rose NR, Woon EC, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.

  [2] Schmiderer C, Grausgruber-Groger S, et al. Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol. 2010 Jul 1;167(10):779-86.