CAS No.: 1019206-88-2
雷戈拉非尼(BAY-734506)一水合物 Catalog No. CSN17331
Synonyms: BAY 73-4506 monohydrate
Regorafenib is a multi-target inhibitor. It can inhibit the activities of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 and their IC50 values range from 1.5 nM to 46 nM.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 c-RET
IC50:1.5nMVEGFR1
IC50:13nMC-Raf
IC50:2.5nMPDGFRβ
IC50:22nMVEGFR2
IC50:4.2nM更多 
- 描述
- 参考文献
- [1] Carr BI, Cavallini A, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol. 2013 Feb;228(2):292-7.
- [2] Wilhelm SM, Dumas J, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1019206-88-2 | 储存条件 |
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| 分子式 | C21H17ClF4N4O4 | 运输 | 蓝冰 | |||
| 分子量 | 500.83 | 别名 | BAY 73-4506 monohydrate | |||
| 溶解度 |
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动物实验配方 |
