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CAS No.: 162011-90-7
Synonyms: MK 966;MK-0966;brand name: Vioxx
Rofecoxib is a potent inhibitor of the COX2-dependent production of PGE2 in human osteosarcoma cells with IC50 of 26±10 nM and Chinese hamster ovary cells expressing human COX-2 with IC50 of 18±7 nM.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00078104 | Healthy Tooth... more >> Extraction Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00543868 | Stomach Ulcer ... more >> Duodenal Ulcer Collapse << | Phase 2 | Completed | - | - |
NCT00261586 | Analgesics | Phase 4 | Completed | - | - |
实验方案
技术信息
CAS号 | 162011-90-7 | 储存条件 |
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分子式 | C17H14O4S | 运输 | 蓝冰 | |||||||||||||
分子量 | 314.36 | 别名 | MK 966;MK-0966;brand name: Vioxx;Ceoxx;Ceeoxx;罗非考昔 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00078104 | Healthy Tooth... more >> Extraction Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00543868 | Stomach Ulcer ... more >> Duodenal Ulcer Collapse << | Phase 2 | Completed | - | - |
NCT00261586 | Analgesics | Phase 4 | Completed | - | - |
NCT00543465 | Arthritis, Rheumatoid ... more >> Osteoarthritis Collapse << | Phase 2 | Terminated | - | - |
NCT00006318 | - | - | Completed | - | United States, Maryland ... more >> Warren G. Magnuson Clinical Center (CC) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00164892 | Cancer of Stomach | Phase 3 | Unknown | - | China ... more >> Combine Gastro-intestinal Cancer Clinic Hong Kong, China Collapse << |
NCT00752921 | Headache | Phase 4 | Unknown | October 2008 | Israel ... more >> Shaare Zedek Medical Center Not yet recruiting Jerusalem, Israel, 91031 Contact: Zev S Wimpfheimer, MD 972 50 868 5466 zevw@hotmail.com Collapse << |
NCT00844727 | Duodenal Polyposis | Phase 2 Phase 3 | Terminated(Drug withdrawal) | - | Norway ... more >> Dept of Medicine, Rikshospitalet Oslo, Norway, 0027 Collapse << |
NCT00165048 | Cancer of Stomach | Phase 3 | Unknown | - | China ... more >> Combined Gastro-intestinal Cancer Clinic Hong Kong, China Collapse << |
NCT00092326 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT00092352 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00092300 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT00092365 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00092378 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT00092339 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT00092313 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT00263094 | Headache | Not Applicable | Completed | - | Israel ... more >> Sheba Medical Center Tel Hashomer, Israel Collapse << |
NCT00390260 | Pain, Postoperative Arthroscop... more >>y Collapse << | Phase 3 | Completed | - | - |
NCT00637988 | Barrett's Esophagus | Phase 4 | Completed | - | - |
NCT00637949 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00004845 | Alzheimer Disease | Phase 2 Phase 3 | Completed | - | - |
NCT00385606 | Advanced Non-Small Cell Lung C... more >>ancer Collapse << | Phase 2 Phase 3 | Completed | - | Italy ... more >> Azienda Ospedaliera S. Giuseppe Moscati, U.O. di Oncologia Medica Monteforte Irpino, AV, Italy, 83024 Ospedale Regionale Miulli, Divisione Medicina Interna Sezione Oncologica Acquaviva delle Fonti, BA, Italy, 70021 IRCCS Oncologico Bari, Oncologia Medica Bari, BA, Italy, 70126 Istituto Oncologico di Bari, U.O. di Oncologia Medica e Sperimentale Bari, BA, Italy, 70126 Policlinico Universitario, Oncologia Medica II Cagliari, CA, Italy, 09042 Ospedale A. Cardarelli Campobasso, CB, Italy, 86100 Ospedale Mariano Santo, U.O. di Oncologia Medica Cosenza, CS, Italy, 87100 Ospedale Umberto di Frosinone Frosinone, FR, Italy, 03031 Ospedale Civile di Legnano Legnano, MI, Italy Ospedale S. Paolo Milano, MI, Italy, 20142 Policlinico Universitario P. Giaccone Palermo, PA, Italy, 90100 Casa di Cura La Maddalena S.p.A., Dipartimento Oncologico Palermo, PA, Italy, 90146 Istituto Oncologico Veneto Padova, PD, Italy Ospedale Civile Umberto I, Day Hospital Oncoematologico Nocera Inferiore, SA, Italy, 84014 Divisione di Oncologia Medica, U.S.L.L. 13 .Noale, VE, Italy, 30033 Ospedale S. Bortolo ULSS 6, U.O. di Oncologia Medica Vicenza, VI, Italy, 36100 Ospedale L. Sacco Milano, Italy Istituto Nazionale dei Tumori , Divisione di Oncologia Medica B Napoli, Italy, 80131 Istituto Nazionale dei Tumori, Divisione di Oncologia Medica C Napoli, Italy, 80131 Second University of Naples Napoli, Italy Ospedale Santa Corona Pietre Ligure, Italy Istituto Regina Elena, Divisione di Oncologia Medica Roma, Italy, 00144 Ospedale S. Giovanni Calibita Gatebenefratelli Roma, Italy, 00186 Ospedale San Camillo - Forlanini Rome, Italy Azienda Ospedaliera Di Busto Arsizio Saronno, Italy Collapse << |
NCT00140920 | Pain | Phase 4 | Terminated(Recruitment/study d... more >>iscontinued after withdrawal of marketing authorisation. No data entered.) Collapse << | - | - |
NCT00140894 | Adenomatous Polyposis Coli | Phase 4 | Terminated | - | - |
NCT00140933 | Pain | Phase 3 | Terminated | - | France ... more >> Laboratoires Merck Sharp & Dohme - Chibret Paris Cedex 8, France, 75114 Collapse << |
NCT01762891 | Antiphospholipid Antibody Synd... more >>rome Collapse << | Not Applicable | Completed | - | - |
NCT00282386 | Colorectal Adenoma | Phase 3 | Completed | - | - |
NCT00050362 | Pain Tooth Ex... more >>traction Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00060476 | Prostate Cancer | Phase 3 | Completed | - | - |
NCT00157872 | Rheumatoid Arthritis | Phase 4 | Completed | - | - |
NCT00026819 | Pain | Phase 2 | Completed | - | United States, Maryland ... more >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00657449 | Acute Pain | Phase 4 | Terminated(See termination rea... more >>son in detailed description.) Collapse << | - | Brazil ... more >> Instituto Ortopedico de Goiania Goiania, Goias, Brazil, 74210-030 Centro de Traumatologia e Ortopedia Goiania, Goiás, Brazil Hospital Mãe de Deus Porto Alegre, RIO Grande DO SUL, Brazil, 90880480 Hospital Sao Zacarias Rio de Janeiro, RJ, Brazil Grupo Hospitalar Conceiçao Porto Alegre, RS, Brazil, 91350200 Hospital Geral do Grajau São Paulo, SP, Brazil, 04822-320 Unifesp - Hsp São Paulo, Brazil, 04063003 SECONCI São Paulo, Brazil, 05001000 Collapse << |
NCT00568295 | Osteoarthritis of the Knee | Phase 3 | Completed | - | - |
NCT00031863 | Colorectal Cancer | Phase 3 | Completed | - | United Kingdom ... more >> Radcliffe Infirmary NHS Trust Oxford, England, United Kingdom, OX2 6HE Collapse << |
NCT00038389 | Glioma Brain ... more >>Neoplasms Collapse << | Phase 1 | Terminated(Unavailability of s... more >>tudy drug.) Collapse << | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
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