|4-(吡啶-4-基)-N-(间甲苯基)噻唑-2-胺|CsnPharm

CAS No.: 315702-99-9

4-(Pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine Catalog No. CSN16665

Synonyms: STF-062247

STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency (VHL-) compared to wild-type (VHL+).

规格	价格	促销价格	库存	数量

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实验方案

技术信息

生物活性

描述Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene arises in the majority of Renal Cell Carcinoma (RCC) and is associated with a high degree of vascularization and poor prognosis. STF-62247 is a small molecule compound that induces autophagy and is selectively cytotoxic towards VHL-deficient cells compared to their VHL wild-type counterparts. After treatment of 1.25 μM STF-62247 for 20 hrs, cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles were larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells indicating autophagy induced by STF-62247. The acidification level significantly increases in VHL-deficient cells following treatment with STF-62247. In vivo, daily treatment with STF-62247 (8 mg/kg, i.p.) significantly reduced tumor growth of VHL-deficient cells in SCID mice, and this decrease in tumor growth was concentration-dependent^[3].
动物研究
剂量
Mice: 2.7 mg/kg, 8 mg/kg^[2] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 2.7 mg/kg, 8 mg/kg^[2] (i.p.)
给药途径	i.p.

[1] Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle. 2008 Oct;7(19):2987-90. Epub 2008 Oct 12.
[2] Turcotte S, Chan DA, et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul 8;14(1):90-102.
[3] Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul 8;14(1):90-102. doi: 10.1016/j.ccr.2008.06.004. PMID: 18598947; PMCID: PMC2819422.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7404 mL
- 18.7022 mL
- 37.4043 mL
- 5 mM
- 0.7481 mL
- 3.7404 mL
- 7.4809 mL
- 10 mM
- 0.3740 mL
- 1.8702 mL
- 3.7404 mL

技术信息

CAS号

315702-99-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H13N3S

运输

蓝冰

分子量

267.35

别名

STF-062247

溶解度

DMSO	500.0 mg/mL (1870.2 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	10 mg/mL	clear
PO	0.5% CMC-Na	32 mg/mL	suspension

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4-(Pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine Catalog No. CSN16665

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