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CAS No.: 144-82-1

磺胺甲二唑 Catalog No. CSN12005

Synonyms: 磺胺甲二唑;磺胺二甲嘧啶

Sulfamethizole a sulfonamide antibiotic for the treatment of urinary tract infection.

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生物活性

描述Sulfamethizole is a sulfathiazole antibacterial agent.Sulfamethizole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. Sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth^[2]. Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<

参考文献

[1] Kerrn MB, Frimodt-Moller N, et al. Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother. 2003 Mar;47(3):1002-9.
[2] Watanabe H, Hastings JW. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990;1017(3):229–234
[3] Kerrn MB, Frimodt-Møller N, Espersen F. Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother. 2003;47(3):1002–1009

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6992 mL
- 18.4958 mL
- 36.9916 mL
- 5 mM
- 0.7398 mL
- 3.6992 mL
- 7.3983 mL
- 10 mM
- 0.3699 mL
- 1.8496 mL
- 3.6992 mL

技术信息

CAS号

144-82-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H10N4O2S2

运输

蓝冰

分子量

270.33

别名

磺胺甲二唑;磺胺二甲嘧啶

溶解度

DMSO	180.0 mg/mL (665.8 mM)
Water	insoluble

动物实验配方

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磺胺甲二唑 Catalog No. CSN12005

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