生物活性

• 描述Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of Trimethoprim and Sulfadiazine produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria^[3]. Sulfadiazine (SD) is a classic antibiotic for intracranial infection. It should be offered as an option for the patients with refractory intracranial infection, especially for patients with lower ability to pay^[4]. Sulfadiazine is a sulfonamide antibiotic used for the treatment of toxoplasmosis. In 100 percent of the ulcers treated with silver sulfadiazine cream (15 patients) the bacterial counts were reduced to 10(5) or less per gram of tissue within the three-week test period, compared to 78.6 percent in those treated with saline (14 patients) and 63.6 percent in those treated with povidone-iodine solution (11 patients). Moreover, the ulcers treated with silver sulfadiazine cream responded more rapidly, with one-third showing bacterial levels of less than 10(5) within three days, and half within a week^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01491438	Venous Ulcers	Not Applicable	Unknown	November 2013	Spain ... more >> Javier Urraca García de Madinabeitia Vitoria-Gasteiz, Álava, Spain Collapse <<
  NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD Collapse <<
  NCT00297752	Burns	Phase 4	Completed	-	Netherlands ... more >> Red Cross Hopsital, Burns Centre Beverwijk, Netherlands, 1942 LE Martini Hospital, Burns centre Groningen, Netherlands, 9728 NZ Medical Centre Rijnmond South, Burns centre Rotterdam, Netherlands, 3075 EA Collapse <<

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• 参考文献

• [1] Torre D, Casari S, et al. Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group. Antimicrob Agents Chemother. 1998 Jun;42(6):1346-9.

  [2] Kucan, J.O., et al. Comparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. J Am Geriatr Soc, 1981. 29(5):232-5.

  [3] Graves RA, Phan KV, Bostanian LA, Mandal TK, Pramar YV. Physicochemical Stability of an Oral Suspension of Trimethoprim 20 mg/mL in Combination with Sulfadiazine 200 mg/mL in PCCA Base SuspendIt. Int J Pharm Compd

  [4] Zhang C, Hu L, Ding X, Lu Y, Hu G. The Role of Sulfadiazine for the Treatment of Refractory Intracranial Infection. Turk Neurosurg. 2015;25(6):895–899

  [5] Kucan JO, Robson MC, Heggers JP, Ko F. Comparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. J Am Geriatr Soc. 1981;29(5):232–235

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