|4-氨基苯磺酰胺|CsnPharm

CAS No.: 63-74-1

4-氨基苯磺酰胺 Catalog No. CSN12007

Synonyms: Sulfanilamide

Sulfanilamide is antibiotic against Gram positive becteria, Gram negative becteria, Chlamydia, working by blocking the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 dihydropteroate Synthetase (bacterial)

IC50:320μM
描述Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase^[2]. Administration of Sulfanilamide with the dosage of 100 mg/kg/day is effective in the prevention of P. carinii infection in the immunosuppressed rat model. When the dosage of sulfaguanidine and Sulfanilamide reduced to 10 mg/kg/day, breakthrough P. carinii infection occurs in the rats^[3]. Sulfanilamide shows IC50 of 286.8 μg/mL for recombinant S. cerevisiae strains with wild-type FOL1 genes, but the single mutation 55Trp to 55Ala or 57Pro to 57Ser within the putative active site of the fungal DHPS confers resistance to Sulfanilamide with IC50 of >800 μg/mL^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01477112	Diabetes Mellitus ... more >> Oxidative Stress Iron Metabolism Disorders Collapse <<	Not Applicable	Completed	-	Venezuela ... more >> Hospital Baudilio Lara Barquisimeto, Lara, Venezuela Collapse <<
NCT01822990	-	-	Completed	-	Spain ... more >> Hospital Universitario de Getafe Getafe, Madrid, Spain, 28905 Collapse <<
NCT01636895	Pregnancy Complications Parasi... more >>tic Collapse <<	Phase 4	Unknown	February 2013	Nigeria ... more >> Damboa Hospital Borno state and Park Lane hospital Enugu state Recruiting Enugu,, borno State and Enugu state, Nigeria Contact: Elvis N Shu Cell: + 234 803 317 0257 shuneba@gmail.com Principal Investigator: Elvis Shu Collapse <<

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参考文献

[1] Meneau I, Sanglard D, et al. Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2004 Jul;48(7):2610-6.
[2] McCullough JL, Maren TH. Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother. 1973;3(6):665–669
[3] Hughes WT, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother.1996;40(4):962–965
[4] Meneau I, Sanglard D, Bille J, Hauser PM. Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2004;48(7):2610–2616

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.8070 mL
- 29.0352 mL
- 58.0704 mL
- 5 mM
- 1.1614 mL
- 5.8070 mL
- 11.6141 mL
- 10 mM
- 0.5807 mL
- 2.9035 mL
- 5.8070 mL

技术信息

CAS号

63-74-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H8N2O2S

运输

蓝冰

分子量

172.20

别名

Sulfanilamide

溶解度

DMSO	33.0 mg/mL (191.6 mM)
Water	Insoluble
Ethanol	16.0 mg/mL (92.9 mM)

动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water

30 mg/mL

suspension

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01477112	Diabetes Mellitus ... more >> Oxidative Stress Iron Metabolism Disorders Collapse <<	Not Applicable	Completed	-	Venezuela ... more >> Hospital Baudilio Lara Barquisimeto, Lara, Venezuela Collapse <<
NCT01822990	-	-	Completed	-	Spain ... more >> Hospital Universitario de Getafe Getafe, Madrid, Spain, 28905 Collapse <<
NCT01636895	Pregnancy Complications Parasi... more >>tic Collapse <<	Phase 4	Unknown	February 2013	Nigeria ... more >> Damboa Hospital Borno state and Park Lane hospital Enugu state Recruiting Enugu,, borno State and Enugu state, Nigeria Contact: Elvis N Shu Cell: + 234 803 317 0257 shuneba@gmail.com Principal Investigator: Elvis Shu Collapse <<
NCT00005864	Colorectal Cancer	Phase 2	Completed	-	United States, Kentucky ... more >> Central Baptist Hospital Lexington, Kentucky, United States, 40503 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109-0752 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210-1240 Collapse <<
NCT03274960	Preterm Birth ... more >> Asymptomatic Bacteriuria in Pregnancy Collapse <<	Not Applicable	Active, not recruiting	November 30, 2019	Zimbabwe ... more >> University of Zimbabwe Harare, Metropolitan, Zimbabwe, +263 Collapse <<
NCT00355667	Congestive Heart Failure	Phase 4	Completed	-	Japan ... more >> The Hospital of Hyogo College of Medicine Nishinomiya, Hyogo, Japan, 663-8501 Collapse <<
NCT00008372	Lung Cancer	Phase 2	Completed	-	United States, California ... more >> Cancer Center and Beckman Research Institute, City of Hope Duarte, California, United States, 91010-3000 USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90033-0804 University of California Davis Cancer Center Sacramento, California, United States, 95817 Collapse <<
NCT02603575	Pneumocystis Pneumonia	Not Applicable	Unknown	-	China ... more >> Beijing Chao Yang Hospital Recruiting Beijing, China, 100020 Contact: Hangyong He, MM 861085231543 cyh_birm@sina.com Collapse <<

4-氨基苯磺酰胺 Catalog No. CSN12007

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