|4-联苯基乙酸|CsnPharm

CAS No.: 5728-52-9

4-Biphenylacetic Acid/4-联苯乙酸 Catalog No. CSN20789

Synonyms: 4-Biphenylacetic acid;BPA;CL 83,544

4-Biphenylacetic acid is used in the synthesis of gastrosparing non-steroidal antiinflammatory drug as a potential non-steroidal antiinflammatory agent.

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400-920-2911

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实验方案

技术信息

生物活性

描述4-biphenylacetic acid (BPAA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea^[1].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03235778	Healthy	Phase 1	Recruiting	March 1, 2018	China, Jilin ... more >> The First Hospital of Jilin University Recruiting Chang Chun, Jilin, China, 130021 Contact: Yanhua Ding, MD (+86)0431-88782015 Collapse <<
NCT03617510	Pain	Phase 1	Recruiting	February 1, 2019	China, Jilin ... more >> The First Hospital of Jilin University Recruiting Changchun, Jilin, China, 130021 Contact: Yanhuan Ding, MD (+86)0431-88782015 dingyanhua2003@126.com Collapse <<

参考文献

[1] Tolman EL, Partridge R, Myers TO, Birnbaum JE. Inhibition of prostaglandin-mediated ocular inflammatory responses by 4-biphenylacetic acid. Invest Ophthalmol. 1976 Dec;15(12):1005-8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.7116 mL
- 23.5578 mL
- 47.1156 mL
- 5 mM
- 0.9423 mL
- 4.7116 mL
- 9.4231 mL
- 10 mM
- 0.4712 mL
- 2.3558 mL
- 4.7116 mL

技术信息

CAS号

5728-52-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H12O2

运输

蓝冰

分子量

212.24

别名

4-Biphenylacetic acid;BPA;CL 83,544;BRN 1211592;4-联苯乙酸

溶解度

DMSO	200.0 mg/mL (942.3 mM)
Water	insoluble

动物实验配方

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