|4-氯-N-(5-(4-氟苯基)-1,3,4-恶二唑-2-基)苯甲酰胺|CsnPharm

CAS No.: 865285-29-6

4-Chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide Catalog No. CSN24747

Synonyms: KKL-35

KKL-35, a potent member of the oxadiazole family, against the human pathogen Legionella pneumophila and other related species that can also cause Legionnaires' disease.

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400-920-2911

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技术信息

生物活性

描述KKL-35 is a trans-translation tagging reaction inhibitor with an IC50 of 0.9 µM. KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 prevents growth of WT S. flexneri with a MIC of 6 µM, and addition of KKL-35 to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of E. coli ∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM. In vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translationRamadoss NS, Alumasa JN, Cheng L, et al. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013;110(25):10282-10287｜https://pubmed.ncbi.nlm.nih.gov/23733947. KKL-35 was also active against other LD-causing (Legionnaires' disease) Legionella species. KKL-35 remained equally active against L. pneumophila mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of L. pneumophila in human macrophages at several stages of infectionBrunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition. Antimicrob Agents Chemother. 2018;62(2):e01459-17.https://pubmed.ncbi.nlm.nih.gov/29158279. KKL-35, is bactericidal against MTB (Mycobacterium tuberculosis) under both aerobic and anoxic conditionsAlumasa JN, Manzanillo PS, Peterson ND, et al. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017;3(9):634-644｜https://pubmed.ncbi.nlm.nih.gov/28762275.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1476 mL
- 15.7380 mL
- 31.4760 mL
- 5 mM
- 0.6295 mL
- 3.1476 mL
- 6.2952 mL
- 10 mM
- 0.3148 mL
- 1.5738 mL
- 3.1476 mL

技术信息

CAS号

865285-29-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H9ClFN3O2

运输

蓝冰

分子量

317.70

别名

KKL-35

溶解度

DMSO	14.5 mg/mL (45.6 mM)
Water	insoluble

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4-Chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide Catalog No. CSN24747

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