|4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺|CsnPharm

CAS No.: 892711-75-0

4-Isopropoxy-N-(2-methylquinolin-8-yl)benzamide Catalog No. CSN25372

CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

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400-920-2911

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技术信息

生物活性

描述The sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) pumps Ca²⁺ from the cytoplasm into the endoplasmic reticulum (ER). CDN1163 is a small-molecule allosteric activator of SERCA that acts directly on SERCA and improves Ca²⁺ homeostasis. CDN1163 at 1 – 11μM dose-dependently increased the V_max of SERCA2 Ca²⁺-ATPase activity in the ER microsomes from liver tissues. CDN1163 at 10μM rescued cells from H₂O₂-stimulated cell death. In ob/ob male mice, intraperitoneal injection with 300μL of CDN1163 (50mg/kg/day) for 5 days reduced blood glucose levels and improved metabolic parameters compared with the vehicle-treated group. Treatment with CDN1163 also resulted in a 16% decrease in adipose tissue weight, reduced gluconeogenic gene expression, reversed hepatic steatosis, and inhibited ER stress and ER stress-induced apoptosis in ob/ob mice^[3].
参考文献

[1] Kang S, et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98.
[2] Singh R, et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci Rep. 2018 Oct 23;8(1):15633.
[3] Kang S, Dahl R, Hsieh W, Shin A, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98. doi: 10.1074/jbc.M115.705012

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1212 mL
- 15.6062 mL
- 31.2124 mL
- 5 mM
- 0.6242 mL
- 3.1212 mL
- 6.2425 mL
- 10 mM
- 0.3121 mL
- 1.5606 mL
- 3.1212 mL

技术信息

CAS号

892711-75-0

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H20N2O2

运输

蓝冰

分子量

320.39

别名

溶解度

DMSO	64.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	64.0 mg/mL (199.8 mM)

动物实验配方

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4-Isopropoxy-N-(2-methylquinolin-8-yl)benzamide Catalog No. CSN25372

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