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CAS No.: 479-92-5

4-Isopropylantipyrine/4-异丙基安替比林 Catalog No. CSN11226

Synonyms: 4-Isopropylantipyrine;Isopropylphenazone;Isopropylantipyrine

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

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400-920-2911

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生物活性

描述Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors^[3]. Prenatal coadministration of propyphenazone with caffeine or paracetamol caused intrauterine growth retardation but did not increase external or internal or paracetamol caused intrauterine growth retardation but did not increase external or internal congenital anomalies^[4]. On a per milligram basis, the relative analgesic potency of propyphenazone was about twice that of ASA (acetylsalicylic acid)^[5]. Propyphenazone 220 mg was administered orally to volunteers. Maximum plasma concentrations between 1.5 microgram/ml and 3.5 micrograms/ml were found 30 min later. After comparable doses plasma concentrations in dog and rabbit were lower^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3421 mL
- 21.7103 mL
- 43.4206 mL
- 5 mM
- 0.8684 mL
- 4.3421 mL
- 8.6841 mL
- 10 mM
- 0.4342 mL
- 2.1710 mL
- 4.3421 mL

技术信息

CAS号

479-92-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H18N2O

运输

蓝冰

分子量

230.31

别名

4-Isopropylantipyrine;Isopropylphenazone;Isopropylantipyrine;Isopropyrine;异丙安替比林;扑热息痛

溶解度

DMSO	46.0 mg/mL (199.7 mM)

动物实验配方

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4-Isopropylantipyrine/4-异丙基安替比林 Catalog No. CSN11226

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