|4-甲基吡唑|CsnPharm

CAS No.: 7554-65-6

甲吡唑 Catalog No. CSN19521

Synonyms: 4-Methylpyrazole;Antizol;Fomepizolum

Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.

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技术信息

生物活性

描述Fomepizole, 4-methylpyrazole (4-MP), is a competitive antagonist of alcohol dehydrogenase with a binding affinity >8000 times that of ethanol. Fomepizole's wide therapeutic dose range and safety profile confer several advantages over standard ethanol therapy for the treatment of toxic alcohol exposures, including the lack of ethanol-associated side effects^[3]. Fomepizole is a safe and effective antidote in the treatment of ethylene glycol poisoning^[4]. Male and pregnant Sprague-Dawley rats, which were obtained at 19 days gestation, were administered fomepizole 15 mg/kg intraperitoneally. Elevated concentrations of fomepizole were detected in the fetus following maternal administration. Fetal fomepizole concentrations were fivefold higher than maternal serum concentrations. The zero order elimination rate of fomepizole from maternal serum was 7.6 mol/L/h, which was slightly slower than the elimination rate in male rats (12.9 mol/L/h) ^[5]. 1 dose of fomepizole for severe DERs with hypotension unresponsive to fluid resuscitation or for angioedema unresponsive to antihistamines be administered^[6]. Fomepizole may precipitate bradycardia and/or hypotension during hemodialysis. Monitor vital signs closely during and immediately after infusion^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00661141	Aldehyde Dehydrogenase-2 (ALDH... more >>2) Deficiency Collapse <<	Phase 2	Completed	-	United States, Hawaii ... more >> Covance Honolulu CRU Honolulu, Hawaii, United States, 96813 Collapse <<
NCT00346853	Macular Dystrophy, Corneal	Phase 1	Completed	-	United States, Utah ... more >> Moran Eye Center, University of Utah Salt Lake City, Utah, United States, 84132 Collapse <<
NCT00661141	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 12.1797 mL
- 60.8985 mL
- 121.7970 mL
- 5 mM
- 2.4359 mL
- 12.1797 mL
- 24.3594 mL
- 10 mM
- 1.2180 mL
- 6.0899 mL
- 12.1797 mL

技术信息

CAS号

7554-65-6

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H6N2

运输

蓝冰

分子量

82.10

别名

4-Methylpyrazole;Antizol;Fomepizolum;甲吡唑

溶解度

DMSO	99.0 mg/mL (1205.8 mM)
Water	100.0 mg/mL (1218.0 mM) warming

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