|5,7-二羟基-3-(4-甲氧基苯基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 491-80-5

鹰嘴豆芽素A Catalog No. CSN12351

Synonyms: 4-Methylgenistein;Olmelin;4’-methyl Genistein

Biochanin A, a phytoestrogen from Trifolium pratense, is an inhibitor of PTK with IC50 of 91.5 μM. It also can be metabolized in vivo to genistein.

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技术信息

生物活性

描述Anandamide (arachidonoylethanolamide, AEA) is endogenous ligands of cannabinoid CB1 and CB2 receptors and AEA is metabolized by the enzyme fatty acid amide hydrolase (FAAH). Biochanin A (4-Methylgenistein; Olmelin), a major isoflavone in red clover, is a naturally occurring FAAH inhibitor, with IC₅₀ values of 1.8, 1.4 and 2.4 µM for mouse, rat and human FAAH ,respectively^[3]. In vitro, Biochanin A inhibited human osteosarcoma cell growth and colony formation in a dose-dependent manner, and induced apoptosis by triggering activation of the intrinsic mitochondrial pathway and caspase-9 and -3^[4]. In vivo, type 2 diabetes mellitus animals treated with 10, 20 and 40 mg/kg of Biochanin A for 28 days showed significantly decreased blood glucose, reduced insulin resistance and improved inulin sensitivity, compared to model group. These effects might be linked to its effects on SIRT1^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02174666	Osteopenia Os... more >>teoporosis Collapse <<	Not Applicable	Unknown	September 2016	Denmark ... more >> Aarhus University Hospital Aarhus, Central Jutland Region, Denmark, 8000 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

491-80-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

4-Methylgenistein;Olmelin;4’-methyl Genistein;5,7-dihydroxy-4'-Methoxyisoflavone;NSC 123538;Biochanin;Pratensol;鹰嘴豆芽素A

溶解度

DMSO	56.0 mg/mL (197.0 mM)
Water	Insoluble
Ethanol	9.0 mg/mL (31.7 mM)

动物实验配方

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