|5-(2-羟乙基)-4-甲基-3-((2-甲基-6-氧代-1,6-二氢嘧啶-5-基)甲基)噻唑-3-鎓氯化物盐酸盐|CsnPharm

CAS No.: 614-05-1

Synonyms: Hydroxythiamine chloride hydrochloride

Oxythiamine is a transketolase inhibitor, a thiamine antagonist and an antimetabolite.

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400-920-2911

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描述Oxythiamine (OT), an analogue of anti-metabolite, is an inhibitor of transketolase, and a thiamine antagonist. Oxythiamine can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. It altered dynamics of protein signals by suppressing phosphor kinase expression in a concentration (0μM, 5μM, 50μM and 500μM)-dependent and time (0h, 12h and 48h)-dependent manner in MIA PaCa-2 cells. A time-dependent, but not dose-dependent, down-regulation of Annexin A1 expression was observed. The inhibition of transketolase by Oxythiamine resulted in changes of multiple cellular signaling pathways associated with cell apoptosis.
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CAS号	614-05-1	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C12H17Cl2N3O2S	运输	蓝冰
分子量	338.25	别名	Hydroxythiamine chloride hydrochloride

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