|6-氨基-5-氟嘧啶-2(1H)-酮|CsnPharm

CAS No.: 2022-85-7

5-Fluorocytosine/5-氟胞嘧啶 Catalog No. CSN19360

Synonyms: 5-Fluorocytosine;NSC 103805;Ro 2-9915

5-Fluorocytosine is an antimycotic prodrug which can be converted to 5-fluorouracil, working by inhibiting DNA and RNA synthesis and interfering with ribosomal protein synthesis. It shows both antifungal and antitumor activity.

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实验方案

技术信息

生物活性

描述Flucytosine (5-FC, 5-Fluorocytosine) is a synthetic antimycotic compound. In combination with amphotericin B, 5-FC can be used to treat severe systemic mycoses, such as cryptococcosis, candidosis, chromoblastomycosis and aspergillosis. Moreover, 5-FC has been combined with newer azole antifungal agents; it also plays an important role in a new approach to the treatment of cancer. The severe side effects of 5-FC include hepatotoxicity and bone-marrow depression^[3]. 5-FC half-life in the serum of 10 rabbits increased from 3.35 +/- 0.27 to 24.63 +/- 0.70 hr after experimentally induced acute renal failure. Concentrations of 5-FC in the cerebrospinal fluid of five patients ranged from 17 to 62 mug/ml and were 74.4 +/- 5.6% of simultaneously determined serum concentrations^[4]. The 5FC-FCZ (fluconazole, FCZ) combination was antagonistic against Candida species, but for some Candida isolates synergism was found. For C. neoformans the interaction for both combinations was highly dependent on the tested isolate and the method used^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00583492	-	-	Completed	-	-
NCT00583492	Prostate Cancer	Phase 2	Completed	-	United States, Maryland ... more >> Johns Hopkins University School of Medicine Baltimore, Maryland, United States, 21231 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 Collapse <<
NCT02742649	Open-Angle Glaucoma ... more >> Ocular Hypertension Collapse <<	Phase 1 Phase 2	Completed	-	Panama ... more >> Clinica de Ojos Orillac - Calvo Panama City, Panama Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.7464 mL
- 38.7319 mL
- 77.4638 mL
- 5 mM
- 1.5493 mL
- 7.7464 mL
- 15.4928 mL
- 10 mM
- 0.7746 mL
- 3.8732 mL
- 7.7464 mL

技术信息

CAS号

2022-85-7

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H4FN3O

运输

蓝冰

分子量

129.09

别名

5-Fluorocytosine;NSC 103805;Ro 2-9915;5-FC;Flucytosin;5-氟胞嘧啶;卡培他滨

溶解度

DMSO	8.0 mg/mL (62.0 mM)
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00583492	-	-	Completed	-	-
NCT00583492	Prostate Cancer	Phase 2	Completed	-	United States, Maryland ... more >> Johns Hopkins University School of Medicine Baltimore, Maryland, United States, 21231 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 Collapse <<
NCT02742649	Open-Angle Glaucoma ... more >> Ocular Hypertension Collapse <<	Phase 1 Phase 2	Completed	-	Panama ... more >> Clinica de Ojos Orillac - Calvo Panama City, Panama Collapse <<
NCT00012467	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, Missouri Washington Univ St Louis, Missouri, United States, 63108 United States, New Jersey UMDNJ - New Jersey Med School / Cooper Hosp Camden, New Jersey, United States, 08103 Univ of Med & Dentistry of New Jersey Newark, New Jersey, United States, 07103 United States, Texas Houston Veterans Administration Med Ctr Houston, Texas, United States, 77030 Univ of Texas / Med School at Houston Houston, Texas, United States, 77030 Audie L Murphy Veterans Administration Hosp San Antonio, Texas, United States, 78284 Peru Hosp Nacional dos de Mayo Lima, Peru Instituto de Medicina Tropical Lima, Peru Collapse <<
NCT00415454	Pancreatic Cancer	Phase 1	Terminated(Poor enrollment)	-	United States, Michigan ... more >> Henry Ford Health System Detroit, Michigan, United States, 48202 Collapse <<
NCT03029871	Non-small Cell Lung Cancer Sta... more >>ge I Collapse <<	Phase 1	Recruiting	December 31, 2022	United States, Michigan ... more >> Henry Ford Health System Recruiting Detroit, Michigan, United States, 48202 Contact: Benjamin Movsas, MD bmovsas1@hfhs.org Collapse <<
NCT00324025	Cryptococcal Meningitis	Phase 2	Terminated	-	United States, Alabama ... more >> University of Alabama School of Medicine Birmingham, Alabama, United States, 35233 United States, Texas Department of Medicine/Infectious Disease, MC 7881, University of Texas Health Science Center San Antonio, Texas, United States, 78229 Collapse <<
NCT00000776	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, District of Columbia Georgetown Univ Med Ctr Washington, District of Columbia, United States, 20007 United States, Florida Univ of Miami School of Medicine Miami, Florida, United States, 331361013 United States, Illinois Northwestern Univ Med School Chicago, Illinois, United States, 60611 Cook County Hosp Chicago, Illinois, United States, 60612 United States, New York Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Jack Weiler Hosp / Bronx Municipal Hosp Bronx, New York, United States, 10465 Bronx Veterans Administration / Mount Sinai Hosp Bronx, New York, United States, 10468 SUNY / Health Sciences Ctr at Brooklyn Brooklyn, New York, United States, 112032098 SUNY / Erie County Med Ctr at Buffalo Buffalo, New York, United States, 14215 Beth Israel Med Ctr New York, New York, United States, 10003 Mount Sinai Med Ctr New York, New York, United States, 10029 United States, Ohio Ohio State Univ Hosp Clinic Columbus, Ohio, United States, 432101228 Puerto Rico Univ of Puerto Rico San Juan, Puerto Rico, 009365067 Collapse <<
NCT01156584	Glioblastoma ... more >>Anaplastic Astrocytoma Anaplastic Oligodendroglioma Anaplastic Oligoastrocytoma Collapse <<	Phase 1	Completed	-	United States, California ... more >> City of Hope Duarte, California, United States, 91010 UCLA Los Angeles, California, United States, 90095 UCSD San Diego, California, United States, 92093 UCSF San Francisco, California, United States, 94143 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 The Ohio State University Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15232 United States, Texas The Methodist Hospital Research Institute Houston, Texas, United States, 77030 Collapse <<
NCT03281382	Metastatic Pancreatic Cancer	Phase 1	Recruiting	June 30, 2021	United States, Michigan ... more >> Henry Ford Hospital Recruiting Detroit, Michigan, United States, 48202 Contact: David Kwon, MD 313-916-9930 dkwon1@hfhs.org Contact: Janice Freytag, BS 3138748236 jfreyta1@hfhs.org Collapse <<
NCT00002075	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, California ... more >> Dr Robert Larsen Los Angeles, California, United States, 90033 Collapse <<
NCT02414165	Glioblastoma Multiforme ... more >> Anaplastic Astrocytoma Collapse <<	Phase 2 Phase 3	Active, not recruiting	March 2023	-
NCT00000708	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, Florida ... more >> Univ of Miami School of Medicine Miami, Florida, United States, 331361013 United States, Louisiana Tulane Univ School of Medicine New Orleans, Louisiana, United States, 70112 United States, New York Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Mem Sloan - Kettering Cancer Ctr New York, New York, United States, 10021 United States, North Carolina Univ of North Carolina Chapel Hill, North Carolina, United States, 275997215 United States, South Carolina Julio Arroyo West Columbia, South Carolina, United States, 29169 Collapse <<
NCT02576665	Colorectal Cancer ... more >> Triple Negative Breast Cancer Pancreatic Cancer Non-Small Cell Lung Cancer Head and Neck Cancer Ovarian Cancer Lymphoma Sarcoma Bladder Cancer Melanoma IDH1 Mutated Solid Tumors IDH1 Mutated or MGMT Methylated Recurrent HGG (Not Recruiting) Collapse <<	Phase 1	Active, not recruiting	November 2019	United States, Colorado ... more >> Sarah Cannon Research Institute Denver, Colorado, United States, 80218 United States, Florida University of Miami Miami, Florida, United States, 33136 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02136030	Cryptococcal Meningitis	Not Applicable	Unknown	December 2016	Taiwan ... more >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Collapse <<
NCT00002068	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, California ... more >> Davies Med Ctr San Francisco, California, United States, 94114 United States, Delaware Christiana Hosp / Med Ctr of Delaware Wilmington, Delaware, United States, 19899 United States, Florida Univ of South Florida Tampa, Florida, United States, 33612 United States, Maryland Univ of Maryland / Inst of Human Virology Baltimore, Maryland, United States, 212011192 United States, Michigan Henry Ford Hosp Detroit, Michigan, United States, 48202 United States, New York Harlem AIDS Treatment Group / Harlem Hosp Ctr New York, New York, United States, 10037 United States, Tennessee Univ of Tennessee Memphis, Tennessee, United States, 38163 Canada, Ontario Saint Michael's Hosp Toronto, Ontario, Canada Collapse <<
NCT00847678	Cryptococcal Meningitis	Phase 2	Terminated	-	South Africa ... more >> Novartis Investigative Site South Africa, South Africa Collapse <<
NCT00002305	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	-
NCT01985256	Glioblastoma Multiforme ... more >> Anaplastic Astrocytoma Anaplastic Oligodendroglioma Anaplastic Oligoastrocytoma Collapse <<	Phase 1	Completed	-	United States, California ... more >> UC Irivine Irvine, California, United States, 92868 UCLA Los Angeles, California, United States, 90095 UC San Diego, Moores Cancer Center San Diego, California, United States, 92093 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, New Jersey JFK Medical Center New Jersery Edison, New Jersey, United States, 08818 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Collapse <<
NCT00000639	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, California ... more >> USC CRS Los Angeles, California, United States, 90033 Ucsf Aids Crs San Francisco, California, United States, 94110 United States, Florida Univ. of Miami AIDS CRS Miami, Florida, United States, 33136 United States, Hawaii Univ. of Hawaii at Manoa, Leahi Hosp. Honolulu, Hawaii, United States United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 United States, Indiana Indiana Univ. School of Medicine, Infectious Disease Research Clinic Indianapolis, Indiana, United States, 46202 Methodist Hosp. of Indiana Indianapolis, Indiana, United States, 46202 United States, Louisiana Tulane Med. Ctr. - Charity Hosp. of New Orleans, ACTU New Orleans, Louisiana, United States, 70112 United States, Massachusetts Massachusetts General Hospital ACTG CRS Boston, Massachusetts, United States, 02114 Bmc Actg Crs Boston, Massachusetts, United States, 02118 Beth Israel Deaconess Med. Ctr., ACTG CRS Boston, Massachusetts, United States, 02215 United States, Missouri St. Louis ConnectCare, Infectious Diseases Clinic St Louis, Missouri, United States Washington U CRS St. Louis, Missouri, United States United States, New York SUNY - Buffalo, Erie County Medical Ctr. Buffalo, New York, United States, 14215 Beth Israel Med. Ctr. (Mt. Sinai) New York, New York, United States, 10003 Cornell University A2201 New York, New York, United States, 10021 Univ. of Rochester ACTG CRS Rochester, New York, United States, 14642 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 Carolinas HealthCare System, Carolinas Med. Ctr. Charlotte, North Carolina, United States Regional Center for Infectious Disease, Wendover Medical Center CRS Greensboro, North Carolina, United States, 27401 United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 45267 The Ohio State Univ. AIDS CRS Columbus, Ohio, United States, 43210 United States, Pennsylvania Hosp. of the Univ. of Pennsylvania CRS Philadelphia, Pennsylvania, United States, 19104 Pitt CRS Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT01470794	Glioblastoma Multiforme ... more >> Anaplastic Astrocytoma Anaplastic Oligodendroglioma Anaplastic Oligoastrocytoma Collapse <<	Phase 1	Completed	-	United States, California ... more >> UCLA Los Angeles, California, United States, 90095 University of California at San Diego San Diego, California, United States, 92093 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, New Jersey JFK Medical Center Edison, New Jersey, United States, 08820 Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Columbus, Ohio, United States, 43210 United States, Washington Swedish Neuroscience Institute Seattle, Washington, United States, 98122 Collapse <<
NCT00002113	Meningitis, Cryptococcal ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, California ... more >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 UCI Med Ctr Orange, California, United States, 92668 UCSD Med Ctr - Owen Clinic San Diego, California, United States, 921038681 Collapse <<
NCT01562626	Tumors Neopla... more >>sms Cancer Collapse <<	Phase 1 Phase 2	Recruiting	February 2019	United States, Minnesota ... more >> University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Kimberly Brunsvold, RN 612-626-2315 Principal Investigator: Edward Greeno, MD United States, Texas MD Anderson Recruiting Houston, Texas, United States, 77030 Contact: Siqing Fu, MD siqingfu@mdanderson.org Principal Investigator: Siqing Fu, MD Collapse <<
NCT01715922	Cryptococcal Meningitis ... more >> HIV Collapse <<	Phase 2 Phase 3	Unknown	September 2016	Burundi ... more >> CHU Kamenge Bujumbura, Burundi Hôpital Prince Régent Charles Bujumbura, Burundi Hôpital général Bururi, Burundi Hôpital général Kayanza, Burundi Hôpital général Muyinga, Burundi Côte D'Ivoire Service de Maladies Infectieuses & Tropicales - Hôpital Triechville Abidjan, Côte D'Ivoire Service de Neurologie - Hôpital Cocody Abidjan, Côte D'Ivoire Collapse <<
NCT01562132	Cryptococcal Infection Dissemi... more >>nated Collapse <<	Phase 2	Terminated(Stopped in accordan... more >>ce with pre-specified stopping rules for poor recruitment.) Collapse <<	-	Kenya ... more >> Family AIDS Care and Education Services Kisumu, Nyanza, Kenya Family AIDS Care and Education Services Sindo, Nyanza, Kenya Collapse <<
NCT02015819	Adult Anaplastic Astrocytoma ... more >> Adult Anaplastic Oligodendroglioma Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Anaplastic Oligoastrocytoma Collapse <<	Phase 1	Active, not recruiting	June 2019	United States, California ... more >> City of Hope Medical Center Duarte, California, United States, 91010 Collapse <<
NCT01562132	-	-	Terminated(Stopped in accordan... more >>ce with pre-specified stopping rules for poor recruitment.) Collapse <<	-	-
NCT01172964	Adult Anaplastic Astrocytoma ... more >> Recurrent Grade III Glioma Recurrent Grade IV Glioma Adult Anaplastic Oligodendroglioma Adult Brain Tumor Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Mixed Glioma Recurrent Adult Brain Tumor Adult Anaplastic Oligoastrocytoma Recurrent High Grade Glioma Collapse <<	Phase 1	Completed	-	United States, California ... more >> City of Hope Duarte, California, United States, 91010 Collapse <<
NCT03294486	Glioblastoma ... more >>Brain Cancer Collapse <<	Phase 1 Phase 2	Recruiting	September 2021	France ... more >> Groupe Hospitalier Pitié-Salpêtrière Recruiting Paris, France, 75651 Contact: Ahmed IDBAIH, MD 01 42 16 03 85 ahmed.idbaih@aphp.fr Collapse <<
NCT02598011	Newly Diagnosed High Grade Gli... more >>oma (HGG) Collapse <<	Phase 1	Not yet recruiting	-	-
NCT00978107	Hepatocellular Carcinoma	Phase 1	Completed	-	France ... more >> Hôpitaux Civils de Colmar Colmar, France, 68000 Institut Paoli Calmette, Marseille, France, 13000 Hôpitaux Civils de Lyon, Pierre Benite, France, 69495 Centre René Gauducheau Saint Herblain, France, 44800 Hôpitaux Universitaires de Strasbourg Strasbourg, France, 67000 Institut Claudius Regaud Toulouse, France, 31000 Collapse <<
NCT03724071	Colon Cancer ... more >>Digestive System Neoplasm Collapse <<	Phase 1 Phase 2	Recruiting	December 2021	Belgium ... more >> Site No 0201 Recruiting Brussels, Belgium France Site No 0101 Recruiting Lyon, France Germany Site No 0501 Not yet recruiting Mainz, Germany Spain Site No 0701 Recruiting Madrid, Spain Site No 0702 Recruiting Madrid, Spain Collapse <<

5-Fluorocytosine/5-氟胞嘧啶 Catalog No. CSN19360

靶点选择性

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