|2-氨基-3-(5-羟基-1H-吲哚-3-基)丙酸|CsnPharm

CAS No.: 56-69-9

5-Hydroxytryptophan/5-羟色氨 Catalog No. CSN12784

Synonyms: 5-HTP;DL-5-Hydroxytryptophan;H-DL-Trp(5-OH)-OH

5-Hydroxytryptophan is a naturally occurring amino acid which acts as a chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.

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技术信息

生物活性

描述5-Hydroxytryptophan(5-HTP) is a kind of natural amino acid and dietary supplement used as antidepressant, appetite inhibitor and sleep assistant. It is the precursor of neurotransmitter serotonin and the antagonist of reserpine^[3].5-HTP treatment (10-3 - 10-2 M) significantly inhibited cell proliferation through blocking of the S-phase of the cell cycle and increasing apoptotic and necrotic cell death^[4]. Moreover, 4h after 5-HTP administrations, the endogenous serotonin levels increased by fourfold (150mg/kg) in the plasma and brain associated with profound hyperthermia (+3.86±0.24°C, oxidative stress and NO upregulation^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02064309	Long-standing Type 1 Diabetes ... more >>Mellitus Collapse <<	Phase 1 Phase 2	Active, not recruiting	May 2019	Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, SE-75123 Collapse <<
NCT02509143	Postoperative Nausea and Vomit... more >>ing Colorectal Neoplasms Collapse <<	Not Applicable	Completed	-	Korea, Republic of ... more >> National Clinical Research Center, Korean Medicine Hospital, Pusan National University Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 Pusan National University Yangsan Hospital Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 Collapse <<
NCT03364101	Sleep	Not Applicable	Completed	-	United States, New York ... more >> New York University School of Medicine New York, New York, United States, 10016 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5408 mL
- 22.7041 mL
- 45.4082 mL
- 5 mM
- 0.9082 mL
- 4.5408 mL
- 9.0816 mL
- 10 mM
- 0.4541 mL
- 2.2704 mL
- 4.5408 mL

技术信息

CAS号

56-69-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H12N2O3

运输

蓝冰

分子量

220.22

别名

5-HTP;DL-5-Hydroxytryptophan;H-DL-Trp(5-OH)-OH;NSC-92523;Oxitriptan;5-羟基色氨酸

溶解度

DMSO	85.0 mg/mL (386.0 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02064309	Long-standing Type 1 Diabetes ... more >>Mellitus Collapse <<	Phase 1 Phase 2	Active, not recruiting	May 2019	Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, SE-75123 Collapse <<
NCT02509143	Postoperative Nausea and Vomit... more >>ing Colorectal Neoplasms Collapse <<	Not Applicable	Completed	-	Korea, Republic of ... more >> National Clinical Research Center, Korean Medicine Hospital, Pusan National University Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 Pusan National University Yangsan Hospital Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 Collapse <<
NCT03364101	Sleep	Not Applicable	Completed	-	United States, New York ... more >> New York University School of Medicine New York, New York, United States, 10016 Collapse <<
NCT02815969	-	-	Active, not recruiting	January 2020	Netherlands ... more >> University Medical Center Groningen Groningen, Netherlands, 9713 GZ Collapse <<
NCT00227136	Carcinoid Tumors ... more >> Neuroendocrine Tumors Collapse <<	Phase 3	Terminated	-	Canada, Ontario ... more >> St. Joseph's Health Care London, Ontario, Canada, N6A 4V2 Collapse <<
NCT01552811	-	-	Completed	-	Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, SE-75185 Collapse <<
NCT00001918	-	-	Completed	-	United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse <<
NCT02689479	Type 1 Diabetes	Not Applicable	Completed	-	Sweden ... more >> Karolinska University Hospital Stockholm, Sweden Uppsala University Uppsala, Sweden Collapse <<
NCT00100464	Obstructive Sleep Apnea	Phase 4	Completed	-	United States, Florida ... more >> Malcolm Randall VA Medical Center Gainesville, Florida, United States, 32608 Collapse <<
NCT00731003	Irritable Bowel Syndrome	Not Applicable	Completed	-	Netherlands ... more >> Maastricht University Medical Center+ Maastricht, Limburg, Netherlands, 6200AZ Collapse <<
NCT02967354	-	-	Completed	-	-
NCT02967354	Type2 Diabetes	Not Applicable	Completed	-	-
NCT02922725	Major Depressive Disorder	Phase 4	Recruiting	October 2019	United States, Utah ... more >> University of Utah Recruiting Salt Lake City, Utah, United States, 84054 Contact: Hana Sabic 801-587-0332 hana.sabic@utah.edu Collapse <<
NCT00328913	Obesity	Phase 2	Completed	-	Netherlands ... more >> TNO Quality of Life Zeist, Utrecht, Netherlands, 3704HE Collapse <<
NCT03574948	Crohn Disease ... more >> Ulcerative Colitis Fatigue Remission Collapse <<	Phase 2	Not yet recruiting	December 31, 2020	-
NCT02187341	Plasma Cortisol	Not Applicable	Unknown	December 2015	United States, Illinois ... more >> Benedictine University Recruiting Lisle, Illinois, United States, 60532 Principal Investigator: Pedro Del Corral, PhD-MD Collapse <<
NCT02356107	Major Depressive Disorder	Phase 4	Completed	-	United States, Utah ... more >> University of Utah/The Brain Institute Salt Lake City, Utah, United States, 84108 Collapse <<
NCT01514409	Mood	Not Applicable	Completed	-	United Kingdom ... more >> Northumbria University Newcastle Upon Tyne, United Kingdom Collapse <<
NCT02356107	-	-	Completed	-	-

5-Hydroxytryptophan/5-羟色氨 Catalog No. CSN12784

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