|5-O-(反-3,4-二羟基肉桂酰基)-D-奎宁酸|CsnPharm

CAS No.: 906-33-2

新绿原酸 Catalog No. CSN10051

Synonyms: 新绿原酸;trans-5-O-Caffeoylquinic acid

Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein.

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技术信息

生物活性

描述Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein. Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid^[3]. Neochlorogenic acid exhibited an IC50 of 20 µM in human gastric carcinoma cells. After 6 weeks of neochlorogenic acid administration to mice, the average tumor volumes and growth for the untreated control group were significantly higher than the treated groups^[4]. Neochlorogenic acid showed the anti-photoaging effect through ameliorating UVB-induced collagen degradation, reinforcing the skin barrier^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8224 mL
- 14.1119 mL
- 28.2239 mL
- 5 mM
- 0.5645 mL
- 2.8224 mL
- 5.6448 mL
- 10 mM
- 0.2822 mL
- 1.4112 mL
- 2.8224 mL

技术信息

CAS号

906-33-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H18O9

运输

蓝冰

分子量

354.31

别名

新绿原酸;trans-5-O-Caffeoylquinic acid

溶解度

DMSO	225.0 mg/mL (635.0 mM)
Water	insoluble

动物实验配方

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新绿原酸 Catalog No. CSN10051

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