|6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)嘧啶-4-胺|CsnPharm

CAS No.: 1644443-47-9

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine Catalog No. CSN22545

Synonyms: Autophinib

Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM, also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8841 mL
- 14.4205 mL
- 28.8410 mL
- 5 mM
- 0.5768 mL
- 2.8841 mL
- 5.7682 mL
- 10 mM
- 0.2884 mL
- 1.4421 mL
- 2.8841 mL

技术信息

CAS号

1644443-47-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H11ClN6O3

运输

蓝冰

分子量

346.73

别名

Autophinib

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine Catalog No. CSN22545

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