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CAS No.: 23513-14-6

6-Gingerol/6-姜酚 Catalog No. CSN12433

Synonyms: (S)-(+)-[6]Gingerol;6-Gingerol;Gingerol

6-Gingerol is activator transient receptor potential vanilloid receptor TRPV1 and TRP ankyrin receptor TRPA1 with EC50 of 3.3 µM and 10.4 µM. It's a natural chemical found in the rhizomes of ginger (Z. officinale).

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述6-Gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. The height of the biofilm formed with 10 μM and 0 μM 6-gingerol was ~12 and ~25 μm, respectively. The growth of Pseudomonas aeruginosa was slightly inhibited by 0.1-100 μ m 6-gingerol^[3]. Moreover,6-gingerol exhibited protective effects on apoptosis induced by Aβ1–42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3β and enhancing the activation of Akt^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03268655	Colorectal Adenoma	Not Applicable	Not yet recruiting	February 2020	United States, Minnesota ... more >> Epidemiology Clinical Research Center Minneapolis, Minnesota, United States, 55415 Collapse <<
NCT03089593	Healthy Volunteers	Not Applicable	Completed	-	Brazil ... more >> Hospital das Clínicas Belo Horizonte, Minas Gerais, Brazil, 30130-100 Collapse <<
NCT03028454	Muscle Soreness	Not Applicable	Completed	-	United States, Virginia ... more >> Human Performance Laboratory Norfolk, Virginia, United States, 23529 Collapse <<

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参考文献

[1] Chang KW, Kuo CY. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6(10):3334-41.
[2] Radhakrishnan EK, Bava SV, et al. [6] -Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9(8):e104401.
[3] Kim HS, Lee SH, Byun Y, Park HD. 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Sci Rep. 2015 Mar 2;5:8656. doi: 10.1038/srep08656. PMID: 25728862; PMCID: PMC4345325.
[4] Zeng GF, Zong SH, Zhang ZY, Fu SW, Li KK, Fang Y, Lu L, Xiao DQ. The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells. Rejuvenation Res. 2015 Oct;18(5):413-21. doi: 10.1089/rej.2014.1657. Epub 2015 Aug 20. PMID: 25811848; PMCID: PMC4620533.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3969 mL
- 16.9843 mL
- 33.9685 mL
- 5 mM
- 0.6794 mL
- 3.3969 mL
- 6.7937 mL
- 10 mM
- 0.3397 mL
- 1.6984 mL
- 3.3969 mL

技术信息

CAS号

23513-14-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H26O4

运输

蓝冰

分子量

294.39

别名

(S)-(+)-[6]Gingerol;6-Gingerol;Gingerol;6-姜酚;6-姜辣素

溶解度

DMSO	48.0 mg/mL (163.1 mM)

动物实验配方

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6-Gingerol/6-姜酚 Catalog No. CSN12433

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