|嘌呤-6-硫酮|CsnPharm

CAS No.: 50-44-2

6-Mercaptopurine/巯嘌呤 Catalog No. CSN16373

Synonyms: Mercaptopurine;6-MP;6-Thiohypoxanthine

6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.

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技术信息

生物活性

描述6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug^[3]. The purine anti-metabolite 6-mercaptopurine (6-MP) is widely used for the treatment of leukemia and inflammatory diseases. 6-MP increased both NR4A3 expression and NR4A3 transcriptional activity and enhanced glucose transport activity via increasing GLUT4 translocation in both basal and insulin-stimulated L6 cells in an NR4A3-dependent manner^[4]. 6-MP induced G2/M arrest, delayed S-phase progression, and finally induced apoptosis of neural progenitor cells mediated by p53 in the fetal rat telencephalon^[5]. Azathioprine or 6-mercaptopurine may be effective as maintenance therapy for patients who have failed or cannot tolerate mesalazine or sulfasalazine and for patients who require repeated courses of steroids^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A549 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay, IC50=47 μM	19711987
A549 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay, IC50=47 μM	22705001
Aspc-1 cells	-	Cytotoxicity assay	-	Cytotoxicity against human Aspc-1 cells by crystal violet staining, IC50=2.45 μM	20930123

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临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03553238	Leukemia, Acute ... more >> Leukemia, T Cell Leukemia, Lymphoblastic Collapse <<	Phase 2 Phase 3	Recruiting	August 30, 2020	China, Guangdong ... more >> Nanfang Hospital, Southern Medical University Recruiting Guangzhou, Guangdong, China, 510515 Contact: Hongsheng Zhou, MD, PhD +862062787349 zhs1@i.smu.edu.cn Collapse <<
NCT03716388	Ulcerative Colitis Chronic Mil... more >>d Ulcerative Colitis Chronic Moderate Collapse <<	Phase 3	Not yet recruiting	December 1, 2019	-
NCT00180128	Leukemia, Promyelocytic, Acute	Phase 4	Unknown	November 2012	Germany ... more >> Department of Medicine I, University Hospital Carl Gustav Carus Recruiting Dresden, Germany, 01307 Contact: Markus Schaich, MD +49-351-458 ext -4251 markus.schaich@uniklinikum-dresden.de Contact: Silke Soucek +49-351-458 ext -4251 silke.soucek@uniklinikum-dresden.de Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.5713 mL
- 32.8565 mL
- 65.7129 mL
- 5 mM
- 1.3143 mL
- 6.5713 mL
- 13.1426 mL
- 10 mM
- 0.6571 mL
- 3.2856 mL
- 6.5713 mL

技术信息

CAS号

50-44-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H4N4S

运输

蓝冰

分子量

152.18

别名

Mercaptopurine;6-MP;6-Thiohypoxanthine;6-thiopurine;6-mercaptopurine;6-巯基嘌呤

溶解度

DMSO	28.0 mg/mL (184.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

A549 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay, IC50=47 μM	19711987
A549 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay, IC50=47 μM	22705001
Aspc-1 cells	-	Cytotoxicity assay	-	Cytotoxicity against human Aspc-1 cells by crystal violet staining, IC50=2.45 μM	20930123
CCRF-CEM cells	-	Proliferation assay	96 h	Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50=1 μM	21741130
CCRF-SB cells	-	Proliferation assay	96 h	Antiproliferative activity against human CCRF-SB cells after 96 hrs by MTT assay, CC50=1.1 μM	21741130
Colo-357 cells	-	Cytotoxicity assay	-	Cytotoxicity against human Colo-357 cells by crystal violet staining, IC50=6.12 μM	20930123
HEK293 cells	-	Proliferation assay	3 days	Antiproliferative activity against HEK293 cells after 3 days by MTT conversion assay, IC50=0.007 μM	16643040
HeLa cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay, IC50=2.9 μM	19711987
HeLa cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay, IC50=2.9 μM	22705001
human CCRF-CEM cells	-	Proliferation assay	-	Antiproliferative activity against human CCRF-CEM cells by MTT assay, IC50=1 μM	17254669
human CCRF-SB cells	-	Proliferation assay	-	Antiproliferative activity against human CCRF-SB cells by MTT assay, IC50=1 μM	17254669
human DAN-G cells	-	Cytotoxicity assay	-	Cytotoxicity against human DAN-G cells by crystal violet staining, IC50=4.06 μM	20930123
human DU145 cells	-	Proliferation assay	-	Antiproliferative activity against human DU145 cells by MTT assay, IC50=2 μM	17254669
human DU145 cells	-	Proliferation assay	96 h	Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay, CC50=2 μM	21741130
human HepG2 cells	-	Proliferation assay	-	Antiproliferative activity against human HepG2 cells by MTT assay, IC50=8 μM	17254669
human HepG2 cells	-	Proliferation assay	96 h	Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay, CC50=8 μM	21741130
human MCF7 cells	-	Proliferation assay	-	Antiproliferative activity against human MCF7 cells by MTT assay, IC50=3 μM	17254669
human PANC1 cells	-	Cytotoxicity assay	-	Cytotoxicity against human PANC1 cells by crystal violet staining, IC50=6.39 μM	20930123
human PBMC	-	Function assay	4 days	Inhibition of T cell mitogen-induced blastogenesis in human PBMC after 4 days, IC50=0.1495 μM	18467007
human SK-MEL-28 cells	-	Proliferation assay	-	Antiproliferative activity against human SK-MEL-28 cells by MTT assay, IC50=15 μM	17254669
L1210 leukemia cells	-	Function assay	-	Inhibitory concentration on multidrug-resistant L1210 leukemia cells, IC50=0.024 μM	1906107
MCF7 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay, IC50=1.4 μM	19711987
MCF7 cells	-	Proliferation assay	96 h	Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay, CC50=3.2 μM	21741130
MCF7 cells	-	Cytotoxicity assay	-	Cytotoxicity against human MCF7 cells, IC50=2.79 μM	23411915
MCF7 cells	-	Cytotoxicity assay	48 h	Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay, IC50=1.4 μM	22705001
mouse J774 cells	-	Proliferation assay	72 h	Antiproliferative activity against mouse J774 cells assessed as reduction of cell growth after 72 hrs by MTT method, IC50=0.003 μM	10757708
mouse J774.A1 cells	-	Proliferation assay	3 days	Antiproliferative activity against mouse J774.A1 cells after 3 days by MTT conversion assay, IC50=0.003 μM	16643040
mouse S49 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against wild type mouse S49 cells assessed as growth inhibition after 72 hrs by trypan blue exclusion assay, EC50=8 μM	221658
MT4 cells	-	Proliferation assay	-	Antiproliferative activity against human MT4 cells by MTT assay, IC50=0.1 μM	17254669
MT4 cells	-	Cytotoxicity assay	96 h	Cytotoxicity against human MT4 cells infected with HTLV-1 after 96 hrs by MTT assay, CC50=0.1 μM	21741130
Patu-02 cells	-	Cytotoxicity assay	-	Cytotoxicity against human Patu-02 cells by crystal violet staining, IC50=9.69 μM	20930123
Patu-S cells	-	Cytotoxicity assay	-	Cytotoxicity against human Patu-S cells by crystal violet staining, IC50=11.07 μM	20930123
Patu-T cells	-	Cytotoxicity assay	-	Cytotoxicity against human Patu-T cells by crystal violet staining, IC50=4.09 μM	20930123
SK-MEL-28 cells	-	Proliferation assay	96 h	Antiproliferative activity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50=15 μM	21741130
T3M4 cells	-	Cytotoxicity assay	-	Cytotoxicity against human T3M4 cells by crystal violet staining, IC50=2.63 μM	20930123
WEHI164 cells	-	Proliferation assay	3 days	Antiproliferative activity against mouse WEHI164 cells after 3 days by MTT conversion assay, IC50=0.015 μM	16643040
WEHI164 cells	-	Proliferation assay	72 h	Antiproliferative activity against mouse WEHI164 cells assessed as reduction of cell growth after 72 hrs by MTT method, IC50=0.017 μM	10757708
WIL2-NS cells	-	Proliferation assay	96 h	Antiproliferative activity against human WIL2-NS cells after 96 hrs by MTT assay, CC50=3 μM	21741130
WIL-2NS cells	-	Proliferation assay	-	Antiproliferative activity against human WIL-2NS cells by MTT assay, IC50=3 μM	17254669

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03553238	Leukemia, Acute ... more >> Leukemia, T Cell Leukemia, Lymphoblastic Collapse <<	Phase 2 Phase 3	Recruiting	August 30, 2020	China, Guangdong ... more >> Nanfang Hospital, Southern Medical University Recruiting Guangzhou, Guangdong, China, 510515 Contact: Hongsheng Zhou, MD, PhD +862062787349 zhs1@i.smu.edu.cn Collapse <<
NCT03716388	Ulcerative Colitis Chronic Mil... more >>d Ulcerative Colitis Chronic Moderate Collapse <<	Phase 3	Not yet recruiting	December 1, 2019	-
NCT00180128	Leukemia, Promyelocytic, Acute	Phase 4	Unknown	November 2012	Germany ... more >> Department of Medicine I, University Hospital Carl Gustav Carus Recruiting Dresden, Germany, 01307 Contact: Markus Schaich, MD +49-351-458 ext -4251 markus.schaich@uniklinikum-dresden.de Contact: Silke Soucek +49-351-458 ext -4251 silke.soucek@uniklinikum-dresden.de Collapse <<
NCT01914770	-	-	Completed	-	-
NCT02200978	Childhood Acute Promyelocytic ... more >>Leukemia Collapse <<	Phase 4	Recruiting	September 2022	China, Guangdong ... more >> The First Affiliated Hospital of Sun Yat-Sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Xue-Qun Luo, professor L-xuequn@126.com Principal Investigator: Xue-Qun Luo, professor Collapse <<
NCT00262925	Recurrent Adult Acute Lymphobl... more >>astic Leukemia Collapse <<	Phase 2	Terminated(slow accrual)	-	-
NCT00187005	Acute Lymphoblastic Leukemia	Phase 3	Terminated(Toxicity)	-	United States, Tennessee ... more >> St.Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00136084	-	-	Completed	-	-
NCT00262925	-	-	Terminated(slow accrual)	-	-
NCT03319901	Leukemia	Phase 1	Recruiting	April 30, 2023	United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Daniel DeAngelo, MD, PhD 617-632-2645 Daniel_DeAngelo@DFCI.Harvard.Edu Principal Investigator: Daniel DeAngelo, MD, PhD United States, Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Nitin Jain, MD 713-745-6080 njain@mdanderson.org Principal Investigator: Nitin Jain, MD Collapse <<
NCT02419755	Mixed Lineage Acute Leukemia ... more >> Acute Myeloid Leukemia Acute Lymphoid Leukemia Collapse <<	Phase 2	Terminated(Accrual goals were ... more >>no longer feasible based on restrictions imposed by the DSMB.) Collapse <<	-	United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00186875	Acute Lymphoblastic Leukemia ... more >> Lymphoma, Lymphoblastic Collapse <<	Phase 2	Completed	-	United States, California ... more >> Rady Children's Hospital and Health Center San Diego, California, United States, 92123 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00136084	Leukemia, Myelocytic, Acute	Phase 3	Completed	-	United States, California ... more >> Stanford University Medical Center Palo Alto, California, United States, 94304 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan Children's Hospital of Michigan (Wayne State University) Detroit, Michigan, United States, 48201 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Cook Children's Medical Center Fort Worth, Texas, United States, 76104 MD Anderson Cancer Center Houston, Texas, United States, 77030 Texas Children's Cancer Center Houston, Texas, United States, 77030 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 Collapse <<
NCT02228772	Acute Lymphoblastic Leukemia ... more >> Lymphoblastic Lymphoma B-cell Adult Acute Lymphoblastic Leukemia T-cell Adult Acute Lymphoblastic Leukemia Collapse <<	Phase 1	Recruiting	July 2021	United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Philip Amrein, MD 617-726-8748 Amrein.Philip@mgh.harvard.edu Principal Investigator: Philip Amrein, MD Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Malgotzata McMasters, MD 617-667-9920 mmcmaste@bidmc.harvard.edu Principal Investigator: Malgorzata McMasters, MD Dana Farber Cancer Institute Not yet recruiting Boston, Massachusetts, United States, 02215 Contact: Daniel DeAngelo, MD, Ph.D 617-632-2645 DDEANGELO@PARTNERS.ORG Principal Investigator: Daniel DeAngelo, MD, Ph.D Collapse <<
NCT02419755	-	-	Terminated(Accrual goals were ... more >>no longer feasible based on restrictions imposed by the DSMB.) Collapse <<	-	-
NCT02419469	Leukemia Prec... more >>ursor-B Acute Lymphoblastic Leukemia Lymphoblastic Lymphoma Lymphoma Collapse <<	Phase 2	Terminated(Slow Accrual)	-	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT00186875	-	-	Completed	-	-
NCT02419469	-	-	Terminated(Slow Accrual)	-	-
NCT00096135	-	-	Completed	-	-
NCT00059839	Lymphoma	Phase 3	Completed	-	-
NCT00096135	Leukemia	Not Applicable	Completed	-	-
NCT00059839	-	-	Completed	-	-
NCT00551460	-	-	Completed	-	-
NCT00609973	Crohn's Disease	Phase 2	Completed	-	United States, North Carolina ... more >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT00551460	Leukemia	Phase 2	Completed	-	-
NCT00109837	Leukemia	Phase 2	Completed	-	-
NCT00408278	Acute Promyelocytic Leukemia	Phase 4	Completed	-	Poland ... more >> PALG Lodz, Poland Spain Hospital General Albacete, Spain Hospital general Alicante, Spain Hospital germans Trias i Pujol Badalona, Spain Hospital Clinic Barcelona, Spain Hospital de Sant Pau Barcelona, Spain Institut Català d'Oncologái Barcelona, Spain Basurtuko Ospitalea Bilbao, Spain Hospital general Castellon, Spain Hospital de Fuenlabrada Fuenlabrada, Spain Hospital "Dr. Trueta" Gerona, Spain Hospital de Jerez de la Frontera Jerez de la Frontera, Spain Hospital Juan Canalejo La Coruña, Spain Hospital Insular de las Palmas Las Palmas de Gran Canaria, Spain Complejo Hospitalario León Leon, Spain Complexo Hospitalario Xeral-Calde Lugo, Spain Hospital 12 de Octubre Madrid, Spain Hospital Clínico San Carlos Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Reina Sofia Madrid, Spain Hospital San Pedro de Alcántara Madrid, Spain Hospital Severo Ochoa Madrid, Spain Hospital Sta. Maria del Rosell Murcia, Spain H. Carlos Haya Málaga, Spain H. Universitario Virgen de la Victoria Málaga, Spain Hospital Central de Asturias Oviedo, Spain Hospital Dr Negrín Palma de Gran Canaria, Spain Hospital de Navarra Pamplona, Spain Hospital de Montecelo Pontevedra, Spain Hospital Clínico Universitario Salamanca, Spain Hospital de Cruces Santander, Spain Hospital de Santiago de Compostela Santiago de Compostela, Spain H.U. Virgen del Rocio Sevilla, Spain Hospital Joan XXIII Tarragona, Spain Hospital Dr. Peset Valencia, Spain Hospital general Valencia, Spain Hospital La Fe Valencia, Spain Hospital Clínico de Valladolid Valladolid, Spain Hospital Txagorritxu Vitoria, Spain Hospital Virgen de la Concha Zamora, Spain Hospital Clínico Universitario Lozano Blesa Zaragoza, Spain Uruguay Hospital Maciel Montevideo, Uruguay Collapse <<
NCT00609973	-	-	Completed	-	-
NCT00819351	Acute Lymphoblastic Leukemia	Phase 3	Completed	-	Denmark ... more >> Department of Pediatrics, Rigshospitalet Copenhagen, Denmark, 2100 Finland Helsinki University Hospital Helsinki, Finland Iceland University Hospital Reykjavik, Iceland Reykjavik, Iceland Norway Trondheim University Hospital Trondheim, Norway Sweden Department of Pediatrics, Drottning Sylvias Pediatric Hospital Gothenburg, Sweden NOPHO nordic organisation for pediatric onology Stockholm, Sweden Collapse <<
NCT02553460	Acute Lymphoblastic Leukemia	Phase 1 Phase 2	Recruiting	October 2031	United States, California ... more >> Children's Hospital Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Paul Gaynon, MD 323-361-4110 pgaynon@chla.usc.edu Principal Investigator: Paul Gaynon, MD Children's Hospital of Orange County Recruiting Orange, California, United States, 92868 Contact: Ivan Kirov, MD 714-997-3000 ikirov@choc.org Principal Investigator: Ivan Kirov, MD Lucile Packard Children's Hospital Stanford University Recruiting Palo Alto, California, United States, 94304 Contact: Norman J. Lacayo, MD 650-497-8953 lacayon@stanford.edu Principal Investigator: Norman J. Lacayo, MD Rady Children's Hospital and Health Center Recruiting San Diego, California, United States, 92123 Contact: Deborah Schiff, MD 858-966-5983 dschiff@chsd.org Principal Investigator: Deborah Schiff, MD United States, Minnesota Children's Hospital and Clinics of Minnesota Recruiting Minneapolis, Minnesota, United States, 55102 Contact: Michael Richards, MD 612-813-5193 Michael.richards@childrensmn.org Principal Investigator: Michael Richards, MD United States, North Carolina St. Jude Affiliate-Charlotte Recruiting Charlotte, North Carolina, United States, 28204 Contact: Christine Bolen, MD 704-384-1900 cybolen@novanthealth.org Principal Investigator: Christine Bolen, MD United States, Ohio Cincinnati Children's Hospital Recruiting Cincinnati, Ohio, United States, 45229 Contact: Erin Breese, MD, PhD 513-636-2799 erin.breese@cchmc.org Principal Investigator: Erin Breese, MD, PhD Rainbow Babies & Children's Hospital Recruiting Cleveland, Ohio, United States, 44106 Contact: Yousif Matloub, MD 216-844-5437 yousif.matloub@uhhospitals.org Principal Investigator: Yousif Matloub, MD United States, Oregon Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Contact: Bill Chang, MD 503-494-1080 changb@ohsu.edu Principal Investigator: Bill Chang, MD United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Tanja A. Gruber, MD, PhD 866-278-5833 tanja.gruber@stjude.org Contact: Referral Office 866-278-5833 referralinfo@stjude.org Principal Investigator: Tanja A. Gruber, MD, PhD United States, Virginia Children's Hospital of the King's Daughters (CHKD) Recruiting Norfolk, Virginia, United States, 23507 Contact: Eric Lowe, MD 757-668-7243 eric.lowe@chkd.org Principal Investigator: Eric Lowe, MD Canada, Alberta Alberta Children's Hospital Recruiting Calgary, Alberta, Canada, T3A 6A8 Contact: Victor A. Lewis, MD 403-220-6898 victor.lewis@ahs.ca Principal Investigator: Victor A. Lewis, MD Stollery Children's Hospital Recruiting Edmonton, Alberta, Canada, T6G 2B7 Contact: Sunil Desai, M.B.Ch.B., FRCP(c) 780-248-5415 sunil.desai@ahs.ca Principal Investigator: Sunil Desai, M.B.Ch.B., FRCP(c) Canada, British Columbia Children's & Women's Health Centre of British Columbia Recruiting Vancouver, British Columbia, Canada, V6H 3V4 Contact: Kirk R. Schultz, MD 604-875-2345 ext 6477 kschultz@mail.ubc.ca Principal Investigator: Kirk R. Schultz, MD Canada, Ontario McMaster Children's Hospital at Hamilton Health Sciences Recruiting Hamilton, Ontario, Canada, L85 4J9 Contact: Uma Athale, MD 905-521-2100 ext 73376 athaleu@mcmaster.ca Principal Investigator: Uma Athale, MD Canada, Quebec The Montreal Children's Hospital (MUHC-McGill) Recruiting Montreal, Quebec, Canada, H4A 3J1 Contact: Catherine Vezina, MD 514-412-4445 catherine.vezina@muhc.mcgill.ca Principal Investigator: Catherine Vezina, MD Centre Hospitalier Universitaire Sainte-Justine Recruiting Montreal, Quebec, Canada, HcT 1C5 Contact: Henrique Bittencourt, MD 514-345-4931 henrique.bittencourt.hsj@ssss.gouv.qc.ca Contact: Yvan Samson yvan.samson@umontreal.ca Principal Investigator: Henrique Bittencourt, MD Centre Hospitalier Universitaire de Quebec Recruiting Québec, Quebec, Canada, G1V 4G2 Contact: Bruno Michon, MD 418-525-4444 bruno.michon@mail.chuq.qc.ca Principal Investigator: Bruno Michon, MD Collapse <<
NCT02303821	Acute Lymphoblastic Leukemia (... more >>ALL) Collapse <<	Phase 1	Recruiting	October 18, 2019	-
NCT01700946	Recurrent B-Cell Childhood Acu... more >>te Lymphoblastic Leukemia Recurrent Childhood B-Lymphoblastic Lymphoma Collapse <<	Phase 2	Recruiting	October 2021	United States, California ... more >> Rady Children's Hospital and Health Center Completed San Diego, California, United States, 92123 United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Sima Jeha, MD 866-278-5833 referralinfo@stjude.org Principal Investigator: Sima Jeha, MD United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Kenneth M. Heym, MD 682-885-4007 Principal Investigator: Kenneth M. Heym, MD Collapse <<
NCT00109837	-	-	Completed	-	-
NCT01358253	Acute Lymphoblastic Leukemia	Phase 4	Completed	-	China, Shanghai ... more >> Ruijin Hospital Shanghai, Shanghai, China, 200025 Collapse <<
NCT02688140	Acute Promyelocytic Leukemia	Phase 3	Recruiting	January 2022	France ... more >> French-Belgian-Swiss APL study group Not yet recruiting Multiple Locations, France Contact: Pierre Fenaux, Prof. Dr. pierre.fenaux@avc.ap-hop-paris.fr Contact: Lionel Ades, Dr. lionel.ades@sls.aphp.fr Germany AML-CG study group Recruiting Multiple Locations, Germany Contact: Eva Lengfelder, Prof. Dr. Eva.Lengfelder@umm.de AML-SG study group Recruiting Multiple Locations, Germany Contact: Richard F. Schlenk, Prof. Dr. Richard.Schlenk@uniklinik-ulm.de OSHO study group Recruiting Multiple Locations, Germany Contact: Dietger Niederwieser, Prof. Dr. Dietger.Niederwieser@medizin.uni-leipzig.de SAL study group Recruiting Multiple Locations, Germany Contact: Uwe Platzbecker, Prof. Dr. +49 351 458 ext 3192 uwe.platzbecker@uniklinikum-dresden.de Contact: Michaela Sauer +49 351 458 ext 3192 michaela.sauer@uniklinikum-dresden.de Italy GIMEMA study group Not yet recruiting Multiple Locations, Italy Contact: Francesco Lo-Coco, Prof. Dr. Francesco.lo.coco@uniroma2.it Contact: Fabio Efficace, Dr. f.efficace@gimema.it Netherlands HOVON study group Not yet recruiting Multiple Locations, Netherlands Contact: Edo Vellenga, Prof. Dr. e.vellenga@umcg.nl Spain PETHEMA study group Not yet recruiting Multiple Locations, Spain Contact: Miguel A. Sanz, Prof. Dr. sanz_mig@gva.es Contact: Pau Montesinos, Prof. Dr. montesinos_pau@gva.es Collapse <<
NCT00866307	-	-	Completed	-	-
NCT00866307	B-cell Adult Acute Lymphoblast... more >>ic Leukemia B-cell Childhood Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse <<	Not Applicable	Completed	-	United States, Arizona ... more >> Phoenix Childrens Hospital Phoenix, Arizona, United States, 85016 United States, California Miller Children's Hospital Long Beach, California, United States, 90806 Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Rady Children's Hospital - San Diego San Diego, California, United States, 92123 University of California San Francisco Medical Center-Parnassus San Francisco, California, United States, 94143 United States, Florida Nemours Children's Clinic-Jacksonville South Jacksonville, Florida, United States, 32207 United States, Georgia Children's Healthcare of Atlanta - Egleston Atlanta, Georgia, United States, 30322 United States, Kentucky University of Kentucky Lexington, Kentucky, United States, 40536 Kosair Children's Hospital Louisville, Kentucky, United States, 40202 United States, Michigan C S Mott Children's Hospital Ann Arbor, Michigan, United States, 48109 United States, New York The Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 United States, North Carolina University of North Carolina Chapel Hill, North Carolina, United States, 27599 United States, Ohio Nationwide Children's Hospital Columbus, Ohio, United States, 43205 United States, Oregon Legacy Emanuel Children's Hospital Portland, Oregon, United States, 97227 Legacy Emanuel Hospital and Health Center Portland, Oregon, United States, 97227 United States, Pennsylvania Children's Oncology Group Philadelphia, Pennsylvania, United States, 19104 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Methodist Children's Hospital of South Texas San Antonio, Texas, United States, 78229 Australia, Western Australia Princess Margaret Hospital for Children Perth, Western Australia, Australia, 6008 Canada, Ontario Children's Hospital of Eastern Ontario Ottawa, Ontario, Canada, K1H 8L1 Collapse <<
NCT03564470	Leukemia Leuk... more >>emia, Acute Leukemia, Lymphoblastic Leukemia, B-cell Collapse <<	Phase 2 Phase 3	Recruiting	August 30, 2020	China, Guangdong ... more >> Department of Hematology, Nanfang Hospital Recruiting Guangzhou, Guangdong, China, 510515 Contact: Hongsheng Zhou, PhD, MD 86-20-62787349 zhs1@i.smu.edu.cn Collapse <<
NCT01458951	Ulcerative Colitis	Phase 3	Completed	-	-
NCT03464136	Crohn Disease	Phase 3	Recruiting	October 22, 2020	-
NCT01064557	Leukemia	Not Applicable	Recruiting	December 2020	-
NCT01465763	Ulcerative Colitis	Phase 3	Completed	-	-
NCT01465763	-	-	Completed	-	-
NCT01451515	Lymphoblastic Lymphoma	Phase 2	Active, not recruiting	June 30, 2021	United States, California ... more >> Rady Children's Hospital San Diego San Diego, California, United States, 92123 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT01458951	-	-	Completed	-	-
NCT00599937	Leukemia, Promyelocytic, Acute	Phase 3	Completed	-	-
NCT00700544	AML Elderly P... more >>atients Collapse <<	Phase 3	Completed	-	France ... more >> Arnaud PIGNEUX Pessac, France, 33604 Collapse <<
NCT03384654	Precursor Cell Lymphoblastic L... more >>eukemia-Lymphoma Collapse <<	Phase 2	Recruiting	August 10, 2021	-
NCT02845232	-	-	Completed	-	France ... more >> Hospices Civils de Lyon - Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet Pierre-benite, France, 69310 Collapse <<
NCT02828358	Acute Leukemia of Ambiguous Li... more >>neage Childhood B Acute Lymphoblastic Leukemia KMT2A Gene Rearrangement Mixed Phenotype Acute Leukemia Collapse <<	Phase 2	Suspended(Met accural pending ... more >>evaluation of enrolled pats.) Collapse <<	September 30, 2019	-
NCT00465933	Acute Promyelocytic Leukemia	Phase 4	Completed	-	Spain ... more >> Basurtuko Ospitalea Basurto, Spain Hospital La Fe de Valencia Valencia, Spain Collapse <<
NCT00176462	Acute Lymphocytic Leukemia	Phase 2	Completed	-	United States, New Jersey ... more >> Jersey Shore University Medical Center Neptune, New Jersey, United States, 07754 Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 Collapse <<
NCT02376478	-	-	Completed	-	-
NCT00176462	-	-	Completed	-	-
NCT00707083	Leukemia	Phase 3	Active, not recruiting	December 31, 2020	China ... more >> Prince of Wales Hospital Hong Kong, China Queen Mary Hospital - Hong Kong Hong Kong, China Collapse <<
NCT02598908	-	-	Recruiting	February 24, 2022	United Kingdom ... more >> Department of Biochemistry, City Hospital Recruiting Birmingham, West Midlands, United Kingdom Contact: Jonathan Berg, FRCPath 01215075345 jonathanberg@nhs.net Contact: Jenna Waldron, FRCPath 01215075025 jenna.waldron@nhs.net Collapse <<
NCT00866749	Lymphoblastic Leukemia ... more >> Lymphoblastic Lymphoma Collapse <<	Phase 2	Completed	-	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02518750	Acute Lymphoblastic Leukemia ... more >> Lymphoma, Non-Hodgkin's Leukemia, T-Cell Leukemia, B-Cell Collapse <<	Phase 2	Terminated(Due to slow accrual... more >>) Collapse <<	-	United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT02396043	Lymphoma, Lymphoblastic	Phase 2	Recruiting	March 2020	China, Guangdong ... more >> Sun Yat-sen University Cancer Center Recruiting GuangZhou, Guangdong, China, 510060 Contact: Zhongjun Xia, MD. 0086-02087342438 zhongjunxia_64@sina.com Collapse <<
NCT00973752	-	-	Completed	-	-
NCT00973752	Acute Lymphoblastic Leukemia	Phase 2	Completed	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse <<
NCT02660762	Leukaemia,Lymphoblastic	Phase 2	Recruiting	January 2019	China, Guangdong ... more >> Sun Yat-sen University Cancer Center Recruiting GuangZhou, Guangdong, China, 510060 Contact: yue lu, MD. 0086-02087342438 dr_luyue@sina.com Collapse <<
NCT03488225	Acute Lymphocytic Leukemia	Phase 2	Recruiting	March 2022	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations ejabbour@mdanderson.org Collapse <<
NCT02451774	Acute Lymphoblastic Leukemia	Phase 2 Phase 3	Recruiting	December 2020	Mexico ... more >> Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" Recruiting Guadalajara, Jalisco, Mexico, 44340 Contact: Ramon O Gonzalez Ramella, PhD 5213331719826 glezramella@hotmail.com Contact: Fabiola P Medina Barajas, PhD 5213313461917 favyri@hotmail.com Collapse <<
NCT03056924	-	-	Recruiting	December 31, 2019	United States, Massachusetts ... more >> Boston Medical Center Recruiting Boston, Massachusetts, United States, 02118 Contact: Sherida S. Padilla, MD 617-638-6527 sherida.padilla@bmc.org Contact: Jill Harrington, MD 617-638-8000 jill.harrington@bmc.org Principal Investigator: Sharmeel K Wasan, MD Collapse <<
NCT02776605	ALL	Phase 2	Recruiting	December 2020	Spain ... more >> Hospital Germans Trias i Pujol Recruiting Badalona, Spain Contact: Josep Mª Ribera, Dr jribera@iconcologia.net Hospital Clinic Recruiting Barcelona, Spain, 08036 Contact: Jordi Esteve, Dr JESTEVE@clinic.ub.es Hospital Universitario Vall d'Hebron Recruiting Barcelona, Spain Contact: Pere Barba, Dr pebarba@vhebron.net Hospital 12 de Octubre Recruiting Madrid, Spain Contact: Mª Pilar Martinez Sánchez, Dr mpmartinezs.hdoc@salud.madrid.org Hospital Virgen de la Victoria Recruiting Málaga, Spain Contact: Mª José Moreno, Dr mjmorenorico@hotmail.com Hospital Clinico Universitario de Salamanca Recruiting Salamanca, Spain Contact: Jesús Maria Hernández Rivas, Dr jmhr@usal.es Hospital Marques de Valdecilla Recruiting Santander, Spain Contact: Mª Aranzazu Bermudez, Dr mbermudez@humv.es C H Santiago de Compostela Recruiting Santiago de Compostela, Spain Contact: Natalia Alonso, Dr natalia.alonso.vence@sergas.es Hospital Virgen del Rocio Recruiting Sevilla, Spain Contact: Jose Gonzalez Campos, Dr jose.gonzalez.sspa@juntadeandalucia.es Hospital Clinico de Valencia Recruiting Valencia, Spain Contact: Mª del Mar Tormo, Dr tormo_mar@gva.es Hospital La Fe Recruiting Valencia, Spain Contact: Pau Montesinos, Dr montesinos_pau@gva.es Collapse <<
NCT02177071	Crohn's Disease	Phase 4	Recruiting	December 2021	Australia ... more >> St Vincent Hospital Recruiting Melbourne, Australia Contact: NIK DONG, MD Nik.DING@svha.org.au Contact: Kylie Parker kylie.PARKER@svha.org.au Principal Investigator: NIK DONG Belgium Gent University Hospital Recruiting Gent, Belgium, 9000 Contact: Martine DE VOS, MD,PhD 003292402371 martine.devos@uzgent.be Principal Investigator: Martine DE VOS, MD,PhD CHU LIEGE - Sart Tilman Recruiting Liege, Belgium, 4000 Contact: Edouard LOUIS, MD,PhD +32436667889 Edouard.Louis@ulg.ac.be Contact: Sylvie WERTZ +32 4 366 74 39 swertz@chu.ulg.ac.be Sub-Investigator: EDOUARD LOUIS, MD France Chu Amiens Recruiting Amiens, France, 80054 Contact: Jean-Louis DUPAS, MD,PhD +33 3 22 66 82 08 dupas.jean-louis@chu-amiens.fr Contact: Martine LECONTE +33 3 22 66 82 14 Principal Investigator: JEAN LOUIS DUPAS, MD Chu Besancon Recruiting Besancon, France, 25030 Contact: LUCINE VUITON, MD Principal Investigator: LUCINE VUITON, MD Sub-Investigator: STEPHANE KOCH, MD Caen Unversity Hospital Recruiting Caen, France, 14033 Sub-Investigator: STEPHANIE VIENNOT, MD Chu Clermont-Ferrand Recruiting Clermont-ferrand, France, 63003 Contact: Gilles BOMMELAER, MD,PhD +33473750523 gbommelaer@chu-clermontferrand.fr Sub-Investigator: Gilles BOMMELAER, MD,PhD Sub-Investigator: ANTONY BUISSON, MD Hopital Beaujon Recruiting Clichy, France, 92110 Contact: Yoram BOUHNIK, MD,PhD +33 1 40 87 56 00 yoram.bouhnik@bjn.aphp.fr Principal Investigator: YORAM BOUHNIK, MD,PhD Sub-Investigator: Alain ATTAR, MD Sub-Investigator: Carmen STEFANESCU, MD Sub-Investigator: Xavier TRETON, MD Hopital Henri Mondor Not yet recruiting Creteil, France, 94010 Contact: Jean-Charles DELCHIER, MD,PhD +33149812351 jean-charles.delchier@hmn.aphp.fr Principal Investigator: Jean-Charles DELCHIER, MD,PhD Sub-Investigator: Aurelien AMIOT, MD Chu Kremlin Bicetre Recruiting Kremlin Bicetre, France Sub-Investigator: FRANCK CARBONNEL, MD Hopital Bicetre Recruiting Le Kremlin Bicetre, France, 94275 Contact: Franck CARBONNEL, MD,PhD +33 1 45 21 37 22 franck.carbonnel@bct.aphp.fr Principal Investigator: Franck CARBONNEL, MD,PhD Chu Lille Recruiting Lille, France Contact: Maria NACHURY, MD Principal Investigator: Maria NACHURY, MD Ch Le Raincy Montfermeil Withdrawn Montfermeil, France, 93370 Chu Montpellier Not yet recruiting Montpellier, France, 34295 Contact: ROMAIN ALTWEGG, MD +33467337394 Sub-Investigator: ROMAIN ALTWEGG, MD Principal Investigator: GUILLAUME PINETON DE CHAMBRUN, MD Chu Nantes Recruiting Nantes, France, 44093 Contact: Arnaud BOURREILLE, MD +33202400830 arnaud.boureille@chu-nantes.fr Principal Investigator: Arnaud BOURREILLE, MD Sub-Investigator: Mathurin FLAMANT, MD CHU NICE Recruiting Nice, France, 06202 Contact: Xavier HEBUTERNE, MD,PhD +33492066168 hebuterne.x@chu-nice.fr Principal Investigator: Xavier HEBUTERNE, MD,PhD Sub-Investigator: Jérome FILIPPI, MD Hopital Saint Louis Recruiting Paris, France, 75010 Contact: Matthieu ALLEZ, MD, PhD 33 1 42 49 95 97 matthieu.allez@sls.aphp.fr Principal Investigator: Mathieu ALLEZ, MD, PhD Sub-Investigator: Jean-Marc GORNET, MD Sub-Investigator: Clotilde BAUDRY, MD Sub-Investigator: Joelle BONNET, MD Hopital St Antoine Recruiting Paris, France, 75012 Contact: Jacques COSNES, MD, PhD +33 1 49 28 31 70 jacques.cosnes@sat.aphp.fr Sub-Investigator: Philippe SEKSIK, MD Principal Investigator: Laurent BEAUGERIE, MD, PhD Hopital Cochin Not yet recruiting Paris, France, 75014 Contact: Vered ABITBOL, MD +33158411967 vered@club-internet.fr Sub-Investigator: Stanislas CHAUSSADE, MD,PhD Principal Investigator: Vered ABITBOL, MD Hopital Saint Joseph Recruiting Paris, France, 75014 Contact: ELISE CHANTELOUP, MD echanteloup@hpsj.fr Principal Investigator: ELISE CHANTELOUP, MD Montsouris Mutualist Institute Recruiting Paris, France, 75674 Sub-Investigator: ANTOINE BLAIN, MD Sub-Investigator: Marion SIMON, MD CHU Bordeaux - Pessac Recruiting Pessac, France, 33700 Contact: David LAHARIE, MD david.laharie@chu-bordeaux.fr Contact: Sylvie RAZAIRE sylvie.razaire@chu-bordeaux.fr Principal Investigator: David LAHARIE, MD CHU LYON Recruiting Pierre Benite, France, 69495 Contact: Bernard FLOURIE, MD,PhD +33478861288 bernard.flourie@chu-lyon.fr Principal Investigator: Bernard FLOURIE, MD,PhD Sub-Investigator: Stéphane NANCEY, MD Chu Reims Active, not recruiting Reims, France Chu Rennes Recruiting Rennes, France, 35033 Contact: Guillaume BOUGUEN, MD +33299284347 guillaume.bouguen@chu-rennes.fr Sub-Investigator: Laurent SIPROUDHIS, MD,PhD Principal Investigator: GUILLAUME BOUGUEN, MD Chu Rouen Not yet recruiting Rouen, France, 76031 Contact: Eric LEREBOURS, MD,PhD +33232888101 eric.lerebours@chu-rouen.fr Principal Investigator: Eric LEREBOURS, MD,PhD Sub-Investigator: Guillaume SAVOYE, MD Chu Saint Etienne Recruiting St Etienne, France, 42270 Contact: Xavier ROBLIN, MD +33 4 77 82 83 20 xavier.roblin@chu-st-etienne.fr Principal Investigator: Xavier ROBLIN, MD Chu Strasbourg Withdrawn Strasbourg, France, 67091 Chu Toulouse Recruiting Toulouse, France, 31403 Contact: Jacques MOREAU, MD +33561322764 moreau.j@chu-toulouse.fr Principal Investigator: Jacques MOREAU, MD Ch Gustave Dron Withdrawn Tourcoing, France, 59208 Chu Tours Recruiting Tours, France, 37044 Contact: Laurence PICON, MD +33247475916 l.picon@chu-tours.fr Sub-Investigator: Laurence PICON, MD Principal Investigator: Alexandre AUBOURG, MD Chr Valencienne Not yet recruiting Valencienne, France, 59300 Contact: MEDINA BOUALIT, MD Principal Investigator: MEDINA BOUALIT, MD Chu Nancy Recruiting Vandoeuvre Les Nancy, France, 54500 Contact: LAURENT PEYRIN BIROULET, MD,PhD +33383153354 Principal Investigator: Laurent PEYRIN-BIROULET, MD,PhD Collapse <<
NCT03719118	Inflammatory Bowel Diseases	Not Applicable	Completed	-	Korea, Republic of ... more >> Severance Hospital Seoul, Korea, Republic of, 03722 Ewha Medical Research Institute Seoul, Korea, Republic of Gangnam Severance Hospital Seoul, Korea, Republic of Korea University Hospital Seoul, Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of Collapse <<
NCT02042690	Acute Lymphoblastic Leukemia	Phase 3	Unknown	December 2018	China, Beijing ... more >> Aerospace Center Hospital Beijing, Beijing, China, 100044 Peking University First Hospital Beijing, Beijing, China, 100044 Collapse <<
NCT03564704	Leukemia Leuk... more >>emia, Acute Adult Lymphoblastic Lymphoma Leukemia, Lymphoblastic Leukemia, T Cell Adult Acute Lymphoblastic Leukemia Lymphoblastic Lymphoma Lymphoblastic Leukemia Collapse <<	Phase 2 Phase 3	Recruiting	May 30, 2021	China, Guangdong ... more >> Department of Hematology, Nanfang Hospital Recruiting Guangzhou, Guangdong, China, 510515 Contact: Hongsheng Zhou +862062787349 zhs1@i.smu.edu.cn Collapse <<
NCT02420717	Leukemia	Phase 2	Recruiting	July 2023	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Collapse <<
NCT00549848	Acute Lymphoblastic Leukemia	Phase 3	Active, not recruiting	November 30, 2020	United States, Tennessee ... more >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT03760003	Ulcerative Colitis	Phase 2	Not yet recruiting	September 30, 2020	-
NCT00184041	Acute Lymphoblastic Leukemia	Phase 2	Completed	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90032 Collapse <<
NCT02877303	Leukemia Acut... more >>e Lymphoblastic Leukemia Collapse <<	Phase 2	Recruiting	November 2020	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Collapse <<
NCT00962767	Leukemia, Myelocytic, Acute	Phase 3	Completed	-	-
NCT00002744	Leukemia	Phase 3	Completed	-	-
NCT03117751	Acute Lymphoblastic Leukemia ... more >> Acute Lymphoblastic Lymphoma Collapse <<	Phase 2 Phase 3	Recruiting	March 31, 2028	United States, Tennessee ... more >> St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Hiroto Inaba, MD, PhD 866-278-5833 referralinfo@stjude.org Principal Investigator: Hiroto Inaba, MD, PhD Collapse <<
NCT02413047	Inflammatory Bowel Disease ... more >> Ulcerative Colitis Crohn's Disease Collapse <<	Not Applicable	Recruiting	December 2018	United States, Indiana ... more >> Indiana University Hospital Recruiting Indianapolis, Indiana, United States, 46062 Contact: Matthew Bohm, DO 317-948-4579 mbohm@iu.edu Sub-Investigator: Monika Fischer, MD Sub-Investigator: Sashi Sagi, MD Collapse <<
NCT00167882	Crohn's Disease ... more >> Ulcerative Colitis Inflammatory Bowel Disease Collapse <<	Phase 4	Completed	-	Netherlands ... more >> Maasland Hospital Sittard, Netherlands Collapse <<
NCT00514982	Hermanski-Pudlak Syndrome ... more >> Colitis Cytokines Lymphocytes Drug Evaluation Collapse <<	Phase 2	Withdrawn	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00846703	Acute Lymphoblastic Leukemia	Phase 4	Unknown	December 2018	China, Guangdong ... more >> The second affiliated hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510000 Contact: Jianpei Fang, M.D. +8620-81332003 jpfang2005@163.com Principal Investigator: Jianpei Fang, M.D. Collapse <<
NCT03370601	Inflammatory Bowel Diseases	Not Applicable	Recruiting	October 2019	France ... more >> CHRU, Hôpital Claude Huriez Recruiting Lille, France Principal Investigator: Benjamin Pariente, MD Collapse <<
NCT01802593	Crohn's Disease	Phase 4	Terminated(lack of budget and ... more >>failure to reach milestones) Collapse <<	-	Israel ... more >> The E. Wolfson.Medical Center Holon, Israel, 58100 Collapse <<
NCT02143414	Acute Lymphoblastic Leukemia ... more >> B Acute Lymphoblastic Leukemia B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative Philadelphia Chromosome Positive Recurrent Adult Acute Lymphoblastic Leukemia Refractory Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Collapse <<	Phase 2	Recruiting	-	-
NCT00492856	Leukemia	Phase 3	Completed	-	-
NCT02578511	Acute Lymphoblastic Leukemia i... more >>n Complete Remission Lymphoblastic Lymphoma in Complete Remission Mixed Phenotype Acute Leukemia in Complete Remission Collapse <<	Phase 1	Withdrawn(No enrollment, anoth... more >>er competing study and difficult to find the right person to enroll on this study.) Collapse <<	-	United States, Wisconsin ... more >> Froedtert & the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Collapse <<
NCT02453607	-	-	Recruiting	June 30, 2020	Canada, Quebec ... more >> Montreal General Hospital Recruiting Montreal, Quebec, Canada, H3G 1A4 Contact: Melissa Diamond, BSc. JD/MSEL 5149341934 ext 44385 melissa.diamond@mail.mcgill.ca Principal Investigator: Ernest Seidman, MDCM Collapse <<
NCT00521950	Inflammatory Bowel Diseases ... more >> Crohn Disease Ulcerative Colitis Collapse <<	Not Applicable	Completed	-	Netherlands ... more >> Radboud University Medical Center Nijmegen, Gelderland, Netherlands, 6500 HB Bernhoven Hospital Oss, Netherlands, 5342 BT Bernhoven Hospital Veghel, Netherlands, 5461 AA Collapse <<
NCT03255668	-	-	Completed	-	Indonesia ... more >> Cipto Mangunkusomo hospital Jakarta Pusat, Jakarta, Indonesia, 10430 Collapse <<
NCT00004688	Anaplastic Astrocytoma ... more >> Anaplastic Oligodendroglioma Mixed Gliomas Glioblastoma Multiforme Recurrent Brain Tumor Collapse <<	Phase 2	Completed	-	-
NCT00089349	Recurrent Childhood Acute Lymp... more >>hoblastic Leukemia Collapse <<	Phase 2	Completed	-	United States, California ... more >> COG Phase I Consortium Arcadia, California, United States, 91006-3776 Collapse <<
NCT00287170	Crohn's Disease	Phase 1 Phase 2	Completed	-	Israel ... more >> Hadassah Medical Center Jerusalem, Israel, 91120 Collapse <<
NCT02852694	Crohn's Disease	Phase 4	Recruiting	July 2022	France ... more >> Hôpital Necker -Enfants Malades (Service de gastro-enterologie) Recruiting Paris, France, 75015 Contact: Frank RUEMMELE, MD +33 (0)144492516 frank.ruemmele@aphp.fr Collapse <<
NCT00492856	-	-	Completed	-	-
NCT01503632	Childhood Acute Lymphoblastic ... more >>Leukemia in Remission Collapse <<	Phase 3	Active, not recruiting	-	-
NCT00003934	Adult Acute Myeloid Leukemia W... more >>ith t(15;17)(q22;q12) Adult Acute Promyelocytic Leukemia (M3) Childhood Acute Promyelocytic Leukemia (M3) Untreated Adult Acute Myeloid Leukemia Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies Collapse <<	Phase 3	Completed	-	United States, Illinois ... more >> Cancer and Leukemia Group B Chicago, Illinois, United States, 60606 United States, North Carolina Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina, United States, 27157 Collapse <<
NCT02281799	Pancreatitis ... more >>Inflammatory Bowel Diseases Collapse <<	Phase 4	Recruiting	January 2019	Israel ... more >> Shaare Zedek Recruiting Jerusalem, Israel, 91031 Collapse <<
NCT00648336	Healthy	Phase 1	Completed	-	United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse <<
NCT00268528	-	-	Active, not recruiting	-	-
NCT02046694	Acute Lymphoblastic Leukemia (... more >>ALL) Collapse <<	Early Phase 1	Recruiting	September 2021	United States, Maryland ... more >> Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21287 Principal Investigator: Colleen Annesley, MD Sub-Investigator: Patrick A Brown, MD United States, Texas Texas Children's Cancer and Hematology Centers Recruiting Houston, Texas, United States, 77030 Contact: Julie Brackett, MD 832-822-4242 Sub-Investigator: Edward Sisson, MD Principal Investigator: Julie Brackett, MD United States, Washington Seattle Children's Hospital Recruiting Seattle, Washington, United States, 98105 Contact: Colleen Annesley, MD Principal Investigator: Colleen Annesley, MD Collapse <<
NCT01629628	Crohn Disease	Phase 3	Unknown	July 2016	Israel ... more >> Department of Gastroenterology and Liver Diseases, Tel-Aviv Soursky Medical Center Not yet recruiting Tel-Aviv, Israel, 64239 Contact: Erez F Scapa, M.D. 972-52-4266345 erezs@tasmc.health.gov.il Principal Investigator: Erez F Scapa, M.D. Collapse <<
NCT00602134	Acute Lymphoblastic Leukemia	Not Applicable	Completed	-	United States, Arizona ... more >> MDS Pharma Services Phoenix, Arizona, United States, 85044 Collapse <<
NCT00816049	Acute Lymphoblastic Leukemia	Phase 3	Completed	-	Denmark ... more >> Department of Pediatrics, Rigshospitalet Copenhagen, Denmark Finland Helsinki University Hospital Helsinki, Finland Iceland University Hospital Reykjavik, Iceland Norway Trondheim University Hospital Trondheim, Norway Sweden Department of Pediatrics, Drottning Sylvias Pediatric Hospital Gothenburg, Sweden NOPHO nordic organisation for pediatric onology Stockholm, Sweden Collapse <<
NCT01697020	Acute Lymphoblastic Leukemia	Phase 1	Completed	-	South Africa ... more >> Parexel International, Bloemfontein Early Phase Clinical Unit Bloemfontein, South Africa Collapse <<
NCT01433432	Crohn's Disease	Phase 2	Withdrawn(Sponsor withdrew sup... more >>port for study due to reorganization and project prioritization) Collapse <<	August 2012	-
NCT03022747	Lymphoblastic Leukemia, Acute,... more >> Childhood Collapse <<	Phase 2	Recruiting	April 2019	Finland ... more >> Dept of Pediatrics and Adolescents, Oulu University Hospital, Box 23, 90029 OYS, Finland Not yet recruiting Oulu, Finland, 90029 OYS Contact: Riita Niinimäki, MD, PhD +358 8 3155832 riita.niinimaki@ppshp.fi Sweden Childrens' Cancer Centre, Queen Silvias Childrens and Adolescents Hospital Recruiting Gothenburg, Sweden, 416 85 Contact: Lene Karlsson, MD +46 313435610 lene.karlsson@vgregion.se Linköping University Hospital, Dept of Pediatrics Not yet recruiting Linköping, Sweden, 58185 Contact: Hartmut Vogt, MD, PhD +46 101031343 hartmut.vogt@regionostergotland.se Collapse <<
NCT02912676	Acute Lymphoblastic Leukemia ... more >> Lymphoblastic Lymphoma Collapse <<	Phase 1 Phase 2	Recruiting	December 2018	Denmark ... more >> Department of Pediatrics, Rigshospitalet Recruiting Copenhagen, Denmark, 2100 Contact: Kjeld Schmiegelow, MD +45 3545 1357 kjeld.schmiegelow@rh.regionh.dk Contact: Rikke H Larsen, MD +45 35457093 rikke.hebo.larsen.01@regionh.dk Sub-Investigator: Rikke H Larsen, MD Rigshospitalet, Department of Hematology Recruiting Copenhagen, Denmark, 2100 Contact: Cecilie U Rank, M.D. +45 35454534 cecilie.utke.rank@regionh.dk Contact: Ove J Nielsen, M.D. +45 35451144 ove.jul.nielsen@regionh.dk Collapse <<
NCT02141100	Non-Hodgkin Lymphoma	Phase 1 Phase 2	Withdrawn	October 2016	Denmark ... more >> Dept. of Pediatric Oncology, JMC, Rigshospitalet Copenhagen, Denmark, 2100 Collapse <<
NCT00548431	Leukemia, Lymphocytic, Acute	Phase 2	Completed	-	Denmark ... more >> Department of Pediatrics, Rigshospitalet Copenhagen, Denmark Department of Pediatrics, University Hospital Odense, Denmark Sweden Department of Pediatrics, Drottning Sylvias Pediatric Hospital Gothenburg, Sweden Collapse <<
NCT01432145	Breast Cancer ... more >> Ovarian Cancer Collapse <<	Phase 2	Completed	-	United Kingdom ... more >> Churchill Hospital Oxford, United Kingdom, OX3 7LJ Collapse <<
NCT01324336	-	-	Unknown	-	United States, Missouri ... more >> The Children's Mercy Hospital Recruiting Kansas City, Missouri, United States, 64108 Contact: Michael Venneman 816-234-3059 mvenneman@cmh.edu Contact: Kathleen A Neville, MD;MS 816-234-3059 kaneville@cmh.edu Principal Investigator: Kathleen A Neville, MD:MS Collapse <<
NCT01094613	Crohn's Disease	Phase 1 Phase 2	Terminated(Sponsor withdrew su... more >>pport of study due to reorganization and project prioritization) Collapse <<	-	Israel ... more >> Ha'emek Medical Center Afula, Israel Bnai Zion Hospital Haifa, Israel Rambam Medical Center Haifa, Israel Hadassah Medical Center Jerusalem, Israel Shaarei Tzedek Medical Center Jerusalem, Israel Meir Medical Center Kfar Saba, Israel Holy Family Hospital Nazareth, Israel Kaplan Medical Center Rehovot, Israel Tel Aviv Sourasky Medical Center Tel Aviv, Israel Sheba Medical Center Tel Hashomer, Israel Assaf Harofeh Zerifin, Israel Collapse <<
NCT02910245	Colitis, Ulcerative	Phase 3	Recruiting	September 2019	Netherlands ... more >> Meander MC Recruiting Amersfoort, Netherlands, 3813 TZ Contact: Bindia Jharap, MD, PhD b.jharap@meandermc.nl OLVG West Withdrawn Amsterdam, Netherlands, 1061 AE MC Slotervaart Recruiting Amsterdam, Netherlands, 1066 EC Contact: Annekatrien CT Depla, MD, PhD actm.depla@slz.nl VU Medical Center Recruiting Amsterdam, Netherlands, 1081 HZ Contact: Nanne de Boer, MD, PhD khn.deboer@vumc.nl Contact: Sara van Gennep, MD +31205667805 s.vangennep@amc.uva.nl OLVG Oost Recruiting Amsterdam, Netherlands, 1090 HM Contact: JM Jansen, MD j.m.jansen@olvg.nl Academic Medical Center Recruiting Amsterdam, Netherlands, 1105AZ Contact: Mark Löwenberg, MD, PhD +31205667621 m.lowenberg@amc.uva.nl Contact: Sara van Gennep, MD +31205667805 s.vangennep@amc.uva.nl Amstelland Hospital Recruiting Amsterdam, Netherlands Contact: M. Gielen, MD margi@zha.nl MC Haaglanden Recruiting Den Haag, Netherlands, 2512 VA Contact: Nidhi Srivastava, MD n.srivastava@mchaaglanden.nl Tergooi Hospital Recruiting Hilversum, Netherlands, 1213 XZ Contact: Itta M Minderhoud iminderhoud@tergooi.nl Contact: Jan van den Brande jvandenbrande@tergooi.nl Westfriesgasthuis Recruiting Hoorn, Netherlands Contact: X.G. Vos, MD, PhD X.G.Vos@westfriesgasthuis.nl St. Antonius Hospital Recruiting Nieuwegein, Netherlands, 3435 CM Contact: Marco Becx, MD m.becx@antoniusziekenhuis.nl Sint Franciscus Gasthuis Recruiting Rotterdam, Netherlands Contact: R. West R.West@Franciscus.nl Collapse <<
NCT00774982	Crohns Disease	Phase 1	Completed	-	Israel ... more >> Hadassah Medical Center Jerusalem, Israel Collapse <<
NCT00548431	-	-	Completed	-	-
NCT01906671	Acute Lymphoblastic Leukemia ... more >> 6-mercaptopurine Therapy Collapse <<	Phase 4	Recruiting	November 2018	Denmark ... more >> Juliane Marie Centret, Rigshospitalet Recruiting Copenhagen, DK-, Denmark, 2100 Contact: Kjeld Schmiegelow, Professor +45 35451357 kjeld.schmiegelow@regionh.dk Contact: Rikke Hebo Larsen, MD +45 35457932 rikke.hebo.larsen.01@regionh.dk Principal Investigator: Kjeld Schmiegelow, Professor Sub-Investigator: Rikke Hebo Larsen, MD Collapse <<
NCT01640548	-	-	Completed	-	-
NCT02551718	Acute Leukemia of Ambiguous Li... more >>neage Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia Refractory Adult Acute Lymphoblastic Leukemia Refractory Childhood Acute Lymphoblastic Leukemia Collapse <<	Not Applicable	Recruiting	-	United States, Washington ... more >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Pamela S. Becker 206-616-1589 pbecker@u.washington.edu Principal Investigator: Pamela S. Becker Collapse <<
NCT02401061	Immune Thrombocytopenia	Phase 1 Phase 2	Recruiting	June 2019	United States, California ... more >> USC Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Howard Liebman, Dr 323-865-3950 liebman_h@med.usc.edu United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Jan Sjoquist 617-726-0153 jsjoquist@mgh.harvard.edu Contact: David Kuter, MD 617-726-8033 dkuter@partners.org Principal Investigator: David Kuter, MD United States, Michigan Michigan Center of Medical Research Recruiting Farmington Hills, Michigan, United States, 48334 Contact: Tallat Mahmood, Dr 248-747-4383 Tallat.mahmood@michmer.com United States, New York Weil-Cornell Medical College Active, not recruiting New York, New York, United States, 10065 United States, Ohio Gabrail Cancer Center Completed Canton, Ohio, United States, 44718 Cleveland Clinic Foundation Completed Cleveland, Ohio, United States, 44195 United Kingdom Aberdeen Royal Infirmary Recruiting Aberdeen, AB, United Kingdom, AB25 27N Contact: Henry Watson, Prof. +44 (0) 1224 693119 henrywatson@nhs.net Principal Investigator: Henry Watson, MD Leicester Royal Infirmary Not yet recruiting Leicester, Leichester, United Kingdom, LE1 5WW Contact: Mamta Garg, MD +44 (0) 1162 586611 mamta.garg@uhl-tr.nhs.uk Principal Investigator: Mamta Garg, MD Queen Elizabeth Hospital Recruiting Birmingham, United Kingdom, B15 2TH Contact: Charles Percy, MD +44 (0) 121 3714898 Charles.Percy@uhb.nhs.uk Principal Investigator: Charles Percy, MD Glasgow Royal Infirmary Recruiting Glasgow, United Kingdom, G4 0SF Contact: Catherine Bagot, MD +44 (0) 1412114000 Catherine.Bagot@ggc.scot.nhs.uk Principal Investigator: Catherine Bagot, MD Norfolk and Norwich Hospital Recruiting Norwich, United Kingdom, NR4 7UY Contact: Lyall Hamish, MD +44 (0) 1603287866 Hamish.Lyall@nnuh.nhs.uk Principal Investigator: Lyall Hamish, MD Collapse <<
NCT03553472	-	-	Recruiting	July 31, 2019	United States, Wisconsin ... more >> University of Wisconsin Digestive Health Center Recruiting Madison, Wisconsin, United States, 53705 Contact: Lindsey Leudke leluedke@medicine.wisc.edu Contact: Freddy Caldera fcaldera@medicine.wisc.edu Principal Investigator: Freddy Caldera, DO Collapse <<
NCT02349061	-	-	Active, not recruiting	-	-
NCT00940524	Leukemia Acut... more >>e Lymphoblastic Leukemia Collapse <<	Phase 1	Completed	-	United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse <<
NCT02521493	Blasts 5 Percent or More of Bo... more >>ne Marrow Nucleated Cells Childhood Acute Myeloid Leukemia Childhood Myelodysplastic Syndrome Cytopenia Down Syndrome Myeloid Leukemia Associated With Down Syndrome Myeloproliferative Neoplasm Trisomy 21 Trisomy 21 Mosaicism Collapse <<	Phase 3	Recruiting	-	-
NCT00476190	Acute Lymphoblastic Leukemia	Phase 2	Active, not recruiting	December 2018	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Children's Hospital of Boston Boston, Massachusetts, United States, 02115 Beth Isreal Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Utah LDS Hospital Salt Lake City, Utah, United States, 84143 Canada, British Columbia Vancouver Cancer Center Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Manitoba Cancer Care Manitoba Winnipeg, Manitoba, Canada, R3E 0V9 Canada, New Brunswick The Moncton Hospital Moncton, New Brunswick, Canada Canada, Nova Scotia QEII, Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 2Y9 Canada, Quebec Hopital Charles LeMoyne Greenfield Park, Quebec, Canada, J4V 2H1 Hopital Maisonneuve Rosemont Montreal, Quebec, Canada, H1T 2M4 Hopital Notre-Dame Montreal, Quebec, Canada McGill University Department of Oncology Montreal, Quebec, Canada Collapse <<
NCT00968253	Leukemia Acut... more >>e Lymphocytic Leukemia Collapse <<	Phase 1 Phase 2	Completed	-	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT01640548	-	-	Completed	-	United Kingdom ... more >> Abergavenny, United Kingdom, NP7 7EG Basildon, United Kingdom, SS16 5NL Basingstoke, United Kingdom, RG24 9NA Belfast, United Kingdom, BT9 7JB Blackburn, United Kingdom, BB2 3HH Bournemouth, United Kingdom, BH7 7DW Cambridge, United Kingdom, CB2 2QQ Cannock, United Kingdom, WS11 5XY Dewsbury, United Kingdom, WF13 4HS Dudley, United Kingdom, DY1 2HQ Durham, United Kingdom, DH15TW Eastbourne, United Kingdom, BN21 2UD Edinburgh, United Kingdom, EH4 2XU Glasgow, United Kingdom, G12 0YN Greenock, United Kingdom, PA16 0XN Harlow, United Kingdom, CM20 1QX Inverness, United Kingdom, IV2 3UV Kirkcaldy, United Kingdom, KY2 5AH London, United Kingdom, SE18 4QH Portsmouth, United Kingdom, PO6 3LY Sheffield, United Kingdom, S10 2JF Truro, United Kingdom, TR1 3LJ Warrington, United Kingdom, WA5 1QG Westbury-on-Trym, Bristol, United Kingdom, BS10 5NB Wigan, United Kingdom, WN6 9EW Wolverhampton, United Kingdom, WV10 0QP Collapse <<
NCT01505855	Crohn's Disease	Phase 4	Completed	-	Korea, Republic of ... more >> Yonsei University: Wonju Christian Hospital Wonju, Kangwon-do, Korea, Republic of, 220-701 Kosin University Gospel Hospital Busan, Korea, Republic of Soonchunhyang University Cheonan, Korea, Republic of Keimyung University; Dongsan Hospital Daegu, Korea, Republic of Wonkwang University Iksan, Korea, Republic of Kyung Hee University Hospital Seoul, Korea, Republic of, 130-702 Asan Medical Center Seoul, Korea, Republic of Chung-Ang University Seoul, Korea, Republic of Ewha Womans University Seoul, Korea, Republic of Inje University; Seoul Paik Hospital Seoul, Korea, Republic of Konkuk University Hospital Seoul, Korea, Republic of Korea University; Ansan Hospital Seoul, Korea, Republic of Yonsei University; Severance Hospital Seoul, Korea, Republic of Seoul National University Hospital Seul, Korea, Republic of The Catholic University of Korea; St. Vincent's Hospital Suwon, Korea, Republic of Collapse <<
NCT02349061	Lupus Erythematosus, Systemic	Phase 2	Active, not recruiting	March 21, 2019	-
NCT02067143	Untreated Philadelphia Positiv... more >>e Acute Lymphoblastic Leukemia De Novo Secondary Low-dose Corticosteroids Pretreatment Collapse <<	Phase 2	Active, not recruiting	October 2018	-
NCT02532738	Crohn's Disease	Phase 2 Phase 3	Unknown	December 2018	-
NCT03390387	Childhood Acute Lymphoblastic ... more >>Leukemia Collapse <<	Not Applicable	Recruiting	November 2025	-
NCT03591770	Inflammatory Bowel Diseases	Phase 4	Not yet recruiting	August 2020	United States, Massachusetts ... more >> Boston Medical Center Boston, Massachusetts, United States, 02118 Collapse <<
NCT00898404	-	-	Completed	-	United States, California ... more >> Children's Oncology Group Arcadia, California, United States, 91006-3776 Collapse <<
NCT00968253	-	-	Completed	-	-
NCT00002514	Leukemia	Phase 3	Completed	-	-
NCT00003437	Leukemia	Phase 3	Unknown	-	United Kingdom ... more >> Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Collapse <<
NCT00003650	Lymphoma	Phase 3	Unknown	-	France ... more >> Centre Leon Berard Lyon, France, 69373 Collapse <<
NCT00003728	Leukemia Lymp... more >>homa Collapse <<	Phase 3	Unknown	-	Belgium ... more >> Ziekenhuis Netwerk Antwerpen Middelheim Antwerp, Belgium, 2020 Hopital Universitaire Des Enfants Reine Fabiola Brussels, Belgium, 1020 Academisch Ziekenhuis der Vrije Universiteit Brussel Brussels, Belgium, 1090 Ghent University Ghent, Belgium, B-9000 Universitair Ziekenhuis Gent Ghent, Belgium, B-9000 U.Z. Gasthuisberg Leuven, Belgium, B-3000 Centre Hospitalier Regional de la Citadelle Liege, Belgium, 4000 Clinique de l'Esperance Montegnee, Belgium, 4420 France Centre Hospitalier Regional et Universitaire d'Angers Angers, France, 49033 CHR de Besancon - Hopital Saint-Jacques Besancon, France, 25030 CHU de Caen Caen, France, 14033 CHU de Grenoble - Hopital de la Tronche Grenoble, France, 38043 Hopital Debrousse Lyon, France, 69322 Hopital Arnaud de Villeneuve Montpellier, France, 34059 CHR Hotel Dieu Nantes, France, 44035 Hopital de l'Archet CHU de Nice Nice, France, F-06202 CHU - Hopital Robert Debre Paris, France, 75019 Hopital Jean Bernard Poitiers, France, 86021 Hopital Americain Reims, France, 51092 Hopital Universitaire Hautepierre Strasbourg, France, 67098 Hopital des Enfants Toulouse, France, 31026 Portugal Hospital Escolar San Joao Porto, Portugal, 4200 Instituto Portugues de Oncologia Centro do Porto, SA Porto, Portugal, 4200 Collapse <<
NCT00005603	Leukemia	Phase 3	Completed	-	United States, California ... more >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford Palo Alto, California, United States, 94304 UCSF Comprehensive Cancer Center San Francisco, California, United States, 94143-0128 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Illinois Saint Jude Midwest Affiliate Peoria, Illinois, United States, 61637 United States, Indiana Indiana University Cancer Center Indianapolis, Indiana, United States, 46202-5289 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 United States, Mississippi University of Mississippi Medical Center Jackson, Mississippi, United States, 39216-4505 United States, New York Albert Einstein Clinical Cancer Center Bronx, New York, United States, 10461 Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032 State University of New York - Upstate Medical University Syracuse, New York, United States, 13210 United States, Ohio Children's Hospital Medical Center - Cincinnati Cincinnati, Ohio, United States, 45229-3039 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97201-3098 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555-0361 University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Baylor College of Medicine Houston, Texas, United States, 77030 United States, Washington Children's Hospital and Regional Medical Center - Seattle Seattle, Washington, United States, 98105 Collapse <<
NCT00002700	Leukemia Lymp... more >>homa Collapse <<	Phase 3	Completed	-	-
NCT00061945	Acute Undifferentiated Leukemi... more >>a B-cell Adult Acute Lymphoblastic Leukemia B-cell Childhood Acute Lymphoblastic Leukemia L1 Adult Acute Lymphoblastic Leukemia L1 Childhood Acute Lymphoblastic Leukemia L2 Adult Acute Lymphoblastic Leukemia L2 Childhood Acute Lymphoblastic Leukemia Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia T-cell Adult Acute Lymphoblastic Leukemia T-cell Childhood Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse <<	Phase 1 Phase 2	Completed	-	United States, Illinois ... more >> Cancer and Leukemia Group B Chicago, Illinois, United States, 60606 Collapse <<
NCT00002531	Leukemia	Phase 2	Unknown	-	Germany ... more >> Klinikum der J.W. Goethe Universitaet Frankfurt, Germany, D-60590 Collapse <<
NCT00003423	Lymphoma	Phase 3	Unknown	-	United Kingdom ... more >> Hospital for Sick Children NHS Trust London, England, United Kingdom, WC1N 3JH Collapse <<
NCT02055781	Primary Myelofibrosis ... more >> Post-polycythemia Vera Myelofibrosis Post-essential Thrombocythemia Myelofibrosis Collapse <<	Phase 3	Terminated	-	-
NCT00022126	Leukemia	Phase 2	Completed	-	-
NCT00002704	Leukemia	Phase 2	Completed	-	-
NCT00002785	Leukemia	Phase 2	Completed	-	-
NCT00002665	Leukemia Neut... more >>ropenia Thrombocytopenia Collapse <<	Phase 2	Completed	-	-
NCT00002701	Leukemia	Phase 3	Unknown	-	-
NCT00002766	Leukemia Lymp... more >>homa Collapse <<	Phase 3	Completed	-	United States, California ... more >> Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California, United States, 90095-1678 Stanford Cancer Center at Stanford University Medical Center Stanford, California, United States, 94305-5750 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 New York Medical College Valhalla, New York, United States, 10595 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Collapse <<
NCT00131027	Lymphoblastic Leukemia, Acute	Phase 3	Unknown	September 2011	Japan ... more >> Department of Hematology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Japan, 466-8550 Contact: Fumihiko Hayakawa, MD bun-hy@med.nagoya-u.ac.jp Principal Investigator: Fumihiko Hayakawa, MD Collapse <<
NCT00002766	-	-	Completed	-	-
NCT00198991	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Unknown	-	Germany ... more >> University of Frankfurt, Medical Dept. II Recruiting Frankfurt, Germany, 60590 Contact: Dieter Hoelzer, MD,PhD ++49(0)69 6301 5194 hoelzer@em.uni-frankfurt.de Contact: Nicola Goekbuget, MD ++49(0)69 6301 6365 goekbuget@em.uni-frankfurt.de Principal Investigator: Dieter Hoelzer, MD,PhD Sub-Investigator: Nicola Goekbuget, MD Collapse <<
NCT00061945	-	-	Completed	-	-
NCT00018954	Leukemia Lymp... more >>homa Collapse <<	Phase 2	Completed	-	United States, Maryland ... more >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 Egypt National Cancer Institute of Egypt Cairo, Egypt India Kidwai Memorial Institute of Oncology Bangalore, India, 560029 Cancer Institute (W.I.A.) Madras, India, 600020 Tata Memorial Centre Mumbai, India, 400012 Collapse <<
NCT00199017	Lymphoma, Lymphoblastic	Phase 4	Completed	-	Germany ... more >> University Hospital, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00131053	Lymphoblastic Leukemia, Acute	Phase 2	Unknown	September 2011	Japan ... more >> Department of Hematology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Japan, 466-8550 Contact: Fumihiko Hayakawa, MD bun-hy@med.nagoya-u.ac.jp Principal Investigator: Fumihiko Hayakawa, MD Collapse <<
NCT00199095	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00199004	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Completed	-	Germany ... more >> University Hospital of Frankfurt, Medical Dept. II Frankfurt, Germany, 60590 Collapse <<
NCT00275106	Lymphoma	Phase 3	Terminated(Withdrawn due to an... more >> excess of toxic deaths) Collapse <<	-	Germany ... more >> Kinderklinik Giessen, Germany, D-35385 Ireland Our Lady's Hospital for Sick Children Crumlin Dublin, Ireland, 12 United Kingdom Birmingham Children's Hospital Birmingham, England, United Kingdom, B4 6NH Institute of Child Health at University of Bristol Bristol, England, United Kingdom, BS2 8AE Addenbrooke's Hospital Cambridge, England, United Kingdom, CB2 2QQ Leeds Cancer Centre at St. James's University Hospital Leeds, England, United Kingdom, LS9 7TF Leicester Royal Infirmary Leicester, England, United Kingdom, LE1 5WW Royal Liverpool Children's Hospital, Alder Hey Liverpool, England, United Kingdom, L12 2AP Royal London Hospital London, England, United Kingdom, E1 1BB Great Ormond Street Hospital for Children London, England, United Kingdom, WC1N 3JH Royal Manchester Children's Hospital Manchester, England, United Kingdom, M27 4HA Sir James Spence Institute of Child Health Newcastle-Upon-Tyne, England, United Kingdom, NE1 4LP Queen's Medical Centre Nottingham, England, United Kingdom, NG7 2UH Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Children's Hospital - Sheffield Sheffield, England, United Kingdom, S10 2TH Southampton General Hospital Southampton, England, United Kingdom, SO16 6YD Royal Marsden - Surrey Sutton, England, United Kingdom, SM2 5PT Royal Belfast Hospital for Sick Children Belfast, Northern Ireland, United Kingdom, BT12 6BE Royal Aberdeen Children's Hospital Aberdeen, Scotland, United Kingdom, AB25 2ZG Royal Hospital for Sick Children Edinburgh, Scotland, United Kingdom, EH9 1LF Royal Hospital for Sick Children Glasgow, Scotland, United Kingdom, G3 8SJ Childrens Hospital for Wales Cardiff, Wales, United Kingdom, CF14 4XW Collapse <<
NCT00003700	Leukemia	Phase 2	Completed	-	-
NCT00002756	Leukemia	Phase 2	Completed	-	-
NCT00343369	Leukemia	Not Applicable	Unknown	-	Germany ... more >> Evangelisches Krankenhauus Bielfeld Recruiting Biefeld, Germany, 33617 Contact: N. Jorch, MD 49-52-177-278-050 Klinikum Bremen-Mitte Recruiting Bremen, Germany, D-28205 Contact: Arnulf Pekrun, MD, PhD 49-421-497-3656 arnulf.pekrun@klinikum-bremen-mitte.de Universitaetsklinikum Duesseldorf Recruiting Duesseldorf, Germany, D-40225 Contact: Contact Person 49-211-311-7990 Universitats - Kinderklinik Recruiting Greiswald, Germany, 17487 Contact: James F. Beck, MD 49-383-486-6325 beck@uni-greifswald.de University Medical Center Hamburg - Eppendorf Recruiting Hamburg, Germany, D-20246 Contact: Gritta Janka-Schaub 49-404-2803-2580 Kreskrankenhaus Kinderabteilung Recruiting Heide, Germany, 25746 Contact: Streitberger 49-481-785-911 Clinic for Bone Marrow Transplantation and Hematology and Oncology Recruiting Idar-Oberstein, Germany, D-55743 Contact: Wenzel Nuernberger, MD, PhD 49-6781-66-1582 wnuernberger@bmt-center-io.com Klinikum Krefeld GmbH Recruiting Krefeld, Germany, D-47805 Contact: P. Thomas 49-2151-322-375 Universitaets - Kinderklinik Recruiting Leipzig, Germany, D-04317 Contact: Dieter Koerholz, MD 49-341-9726-246 koerd@medizin.uni-leipzig.de Johannes Gutenberg University Recruiting Mainz, Germany, D-55101 Contact: P. Gutjahr, MD 49-6131-17-2112 Krankenhaus Neuwerk Klinik fuer Kinder und Jugendmedizin Recruiting Moenchengladbach, Germany, D-41066 Contact: Wolfgang Mueller, MD 49-2161-668-2481 Dr. von Haunersches Kinderspital der Universitaet Muenchen Recruiting Munich, Germany, D-80337 Contact: Arndt Borkhardt 49-89-5160-4498 Staedtisches Krankenhaus Muenchen - Harlaching Recruiting Munich, Germany, D-81545 Contact: Papucek 49-89-6210-2710 Klinik St. Hedwig-Kinderklinik Recruiting Regensburg, Germany, 93049 Contact: Ove Peters 49-941-369-5404 Dr. Horst-Schmidt-Kliniken Recruiting Wiesbaden, Germany, D-65199 Contact: Gerhard Beron, MD 49-611-43-2564 Helios Kliniken Wuppertal University Hospital Recruiting Wuppertal, Germany, D-42283 Contact: B. Dohrn, MD 49-202-896-3823 bdohrn@wuppertal.helios-klinikum.de Collapse <<
NCT00198978	Adult Acute Lymphocytic Leukem... more >>ia Collapse <<	Phase 4	Unknown	-	Germany ... more >> University of Frankfurt, Medical Dept. II Recruiting Frankfurt, Germany, 60590 Contact: Dieter Hoelzer, MD,PhD ++49(0)6963015194 hoelzer@em.uni-frankfurt.de Contact: Nicola Goekbuget, MD ++49(0)6963016365 goekbuget@em.uni-frankfurt.de Principal Investigator: Dieter Hoelzer, MD,PhD Sub-Investigator: Nicola Goekbuget, MD Collapse <<
NCT00400946	Drug/Agent Toxicity by Tissue/... more >>Organ Leukemia Collapse <<	Phase 3	Active, not recruiting	June 2019	United States, Massachusetts ... more >> Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Rhode Island Hasbro Children's Hospital Providence, Rhode Island, United States, 02903 United States, Virginia INOVA Fairfax Hospital Fairfax, Virginia, United States, 22031 Canada, Ontario McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario, Canada, L8N 3Z5 Canada, Quebec Hopital Sainte Justine Montreal, Quebec, Canada, H3T 1C5 Centre de Recherche du Centre Hospitalier de l'Universite Laval Sainte Foy, Quebec, Canada, GIV 4G2 Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 Collapse <<
NCT00526305	Acute Lymphoblastic Leukemia	Phase 4	Completed	-	-
NCT00019409	Leukemia	Phase 3	Withdrawn	-	United States, Maryland ... more >> Pediatric Oncology Branch Bethesda, Maryland, United States, 20892 United States, Texas Texas Tech University Health Sciences Center School of Medicine Amarillo, Texas, United States, 79106 India Kidwai Memorial Institute of Oncology Bangalore, India, 560029 Cancer Institute (W.I.A.) Madras, India, 600020 Tata Memorial Centre Mumbai, India, 400012 All-India Institute of Medical Sciences New Delhi, India, 110029 Collapse <<
NCT00430118	Leukemia	Phase 3	Completed	-	-
NCT00613457	Leukemia	Phase 3	Completed	-	-
NCT02434133	-	-	Completed	-	United States, Wisconsin ... more >> University of Wisconsin Hospital & Clinics Madison, Wisconsin, United States, 53792 Collapse <<
NCT00400946	-	-	Active, not recruiting	-	-
NCT00550992	Leukemia	Not Applicable	Unknown	-	United States, Massachusetts ... more >> Children's Hospital Boston Recruiting Boston, Massachusetts, United States, 02215 Contact: Lewis B. Silverman, MD 617-632-5285 United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Clinical Trials Office - St. Jude Children's Research Hospital 901-595-4644 United States, Texas M. D. Anderson Cancer Center at University of Texas Recruiting Houston, Texas, United States, 77030-4009 Contact: Clinical Trials Office - M. D. Anderson Cancer Center at the U 713-792-3245 United States, Washington Children's Hospital and Regional Medical Center - Seattle Recruiting Seattle, Washington, United States, 98105 Contact: Blythe Thomson, MD 206-987-2106 Austria St. Anna Children's Hospital Recruiting Vienna, Austria, A-1090 Contact: Georg Mann, MD 43-1-4017-1250 Belgium Hopital Universitaire Des Enfants Reine Fabiola Recruiting Brussels, Belgium, 1020 Contact: Alice Ferster, MD 32-2-477-2678 aferster@ulb.ac.be Czech Republic University Hospital Motol Recruiting Prague, Czech Republic, 150 06 Contact: Jan Stary, MD 420-2-2443-6401 jan.stary@lfmotol.cuni.cz France CHR Hotel Dieu Recruiting Nantes, France, 44093 Contact: Francoise Mechinaud, MD 33-1-4249-9046 Germany University Medical Center Hamburg - Eppendorf Recruiting Hamburg, Germany, D-20246 Contact: Gritta Janka-Schaub 49-404-2803-2580 Medizinische Hochschule Hannover Recruiting Hannover, Germany, D-30625 Contact: Martin Schrappe, MD, PhD 49-511-532-6713 Italy Nuovo Ospedale San Gerardo at University of Milano-Bicocca Recruiting Monza, Italy, 20052 Contact: Andrea Biondi, MD 39-039-233-3661 biondi@galactica.it Netherlands Erasmus MC - Sophia Children's Hospital Recruiting Rotterdam, Netherlands, 3015 GJ Contact: Rob Pieters, MD, MSC, PhD 31-10-463-6691 rob.pieters@erasmusmc.nl United Kingdom Great Ormond Street Hospital for Children Recruiting London, England, United Kingdom, WC1N 3JH Contact: Phil Ancliff, MD 44-20-7829-8831 Collapse <<

6-Mercaptopurine/巯嘌呤 Catalog No. CSN16373

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