|740 Y-P游离态|CsnPharm

CAS No.: 1236188-16-1

Synonyms: 740YPDGFR;PDGFR 740Y-P

740 Y-P is cell-permeable peptide activator of PI3K.

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400-920-2911

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描述740 Y-P acts as a cell-permeable phosphopeptide activator of PI3K. It improved both the mitogenic response in C2 muscle cells and survival of cerebellar granule neurons at 50μg/ml, which can be inhibited by wortmannin and rapamycin. Correlated with its action on PI3K, the phosphorylation of Akt, which is an established downstream effector in the PI 3-kinase survival cascade, could be observed post 1h-treatment with 740 Y-P at the concentration of 25μg/ml. Pretreatment with 740 Y-P at 1.53 µM for 30min alleviated the cytolysis of cultured rat neurons induced by sera or IgG of children with Opsoclonus-myoclonus syndrome and neuroblastoma.
作用机制740 Y-P is a peptide that can mimic the phosphorylation of PDGF receptor and bind to the p85 SH2 domain with high affinity.
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技术信息

CAS号	1236188-16-1	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C141H222N43O39PS3	运输	蓝冰
分子量	3270.70	别名	740YPDGFR;PDGFR 740Y-P

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