生物活性

• 描述Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA, with the other three being cytosine (C), guanine (G), and thymine (T). Adenine plays an important role in biochemistry, including cellular respiration and protein synethesis. Rats were treated with adenine sulfate for three weeks after coronary ligation. Adenine sulfate reversed MI-induced reduction of mean artery pressure and left ventricular systolic pressure and elevation of left ventricular end-diastolic pressure. Moreover, adenine sulfate also increased nitric oxide (NO) and nitric oxide synthase (NOS) activity. The amelioration was accompanied by a reversal of the infarction-induced reduction of cholinesterase-positive nerves and M(2)-receptor expression and B(max) in the adenine sulfate high dose group. Meanwhile, adenine sulfate treatment corrected the disorder of cardiac redox state by reduction in maleic dialdehyde and increase in superoxide dismutase^[3]. In intestinal epithelial cells, adenine significantly inhibited tumor necrosis factor-α-induced interleukin-8 secretion. Adenine (5, 10, and 50 mg/kg BW/day) was administered orally for 14 days to female BALB/c mice, and then 5% dextran sodium sulfate (DSS) was given to induce colitis. Adenine (5 mg/kg BW/day) significantly prevented DSS-induced colon shortening, expression of pro-inflammatory cytokines, and histological damage in the colon^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02112916	Adult T Acute Lymphoblastic Le... more >>ukemia Ann Arbor Stage II Adult Lymphoblastic Lymphoma Ann Arbor Stage II Childhood Lymphoblastic Lymphoma Ann Arbor Stage III Adult Lymphoblastic Lymphoma Ann Arbor Stage III Childhood Lymphoblastic Lymphoma Ann Arbor Stage IV Adult Lymphoblastic Lymphoma Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma Childhood T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse <<	Phase 3	Suspended(Other - Temporary cl... more >>osure) Collapse <<	-	-
  NCT03007147	B Acute Lymphoblastic Leukemia... more >> BCR-ABL1 Fusion Protein Expression Minimal Residual Disease Philadelphia Chromosome Positive T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse <<	Phase 3	Recruiting	June 30, 2026	-
  NCT02883049	B Acute Lymphoblastic Leukemia... more >> Central Nervous System Leukemia Ph-Like Acute Lymphoblastic Leukemia Testicular Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse <<	Phase 3	Recruiting	-	-

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• 参考文献

• [1] Sun L, Lu J, et al. Adenine sulfate improves cardiac function and the cardiac cholinergic system after myocardial infarction in rats. J Pharmacol Sci. 2011;115(2):205-13.

  [2] Holtzman JL, Gillette JR. Effect of dietary orotic acid and adenine sulfate on hepatic microsomal enzymes in male and female rats. Biochem Pharmacol. 1969 Aug;18(8):1922-33.

  [3] Sun L, Lu J, Yu XJ, Li DL, Xu XL, Wang B, Ren KY, Liu JK, Zang WJ. Adenine sulfate improves cardiac function and the cardiac cholinergic system after myocardial infarction in rats. J Pharmacol Sci. 2011;115(2):205-13

  [4] Fukuda T, Majumder K, Zhang H, Turner PV, Matsui T, Mine Y. Adenine Inhibits TNF-α Signaling in Intestinal Epithelial Cells and Reduces Mucosal Inflammation in a Dextran Sodium Sulfate-Induced Colitis Mouse Model. J Agric Food Chem. 2016 Jun 1;64(21):4227-34