|8-溴腺苷-3,5-环单磷酸钠|CsnPharm

CAS No.: 76939-46-3

8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt/5'-环单磷酸钠 Catalog No. CSN10180

Synonyms: 8-Br-Camp sodium salt;8-bromo-Cyclic AMP (sodium salt);8-Bromoadenosine 3',5'-cyclic monophosphate

8-Bromo-cAMP is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM and a PKA activator.

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实验方案

技术信息

生物活性

描述The cAMP/PKA signaling pathway regulates a wide range of cellular processes. 8-Bromo-cAMP is an activator of PKA with a K_a value of 0.05 μM^[3]. Treatment of 0.1 and 0.5 mM 8-Bromo-cAMP significantly increased the number of NANOG positive ES cell-like colonies in human fibroblast cells compared to the negative control. The combination of 0.1 mM 8-Bromo-cAMP and 0.5 mM VPA inhibited the proliferation rates at day 3, 4 and 5 in HFF1 cells. The same co-treatment of 8-Bromo-cAMP and VPA in HFF1 cells also induced the upregulation of cytokine-related and inflammatory pathways at day 1, and down-regulated the p53, cell cycle and RB pathways^[4]. In BEAS-2B cells, pretreatment of 100 μM 8-Bromo-cAMP for one hour significantly reduced HDE-induced release of IL-6 and IL-8 compared to cells only received 24-h treatment of 5% HDE with presence of 100 μM 8-Br-cAMP. Also in BEAS-2B cells, HDE (5%) significantly promoted the maximal PKC-ε activity at 6h, but pretreatment with 100 μM 8-Bromo-cAMP for hour blocked HDE-stimulated PKC-ε. The 1-h treatment with 8-Bromo-cAMP (0.1–10 μM) also significantly increased PKA activity in a dose-dependent manner^[5]. In ddY mice, pretreatment with 8-Br-cAMP (i.p., 10 mg/kg) prior to LPS injection significantly inhibited LPS-induced dye leakage in the skin and the increase of serum TNF-α level^[6].
作用机制8-Bromo-cAMP is a brominated derivative of cAMP that functions as a cell-permeable analog of cAMP to activate cAMP-dependent protein kinase (PKA)^[5].
动物研究
剂量
Cat: 0.35 mg/kg - 1 mg/kg^[3] (intra-arterial injection) Mice: 330 mg/kg^[4] (i.p.), 10 mg/kg^[5] (i.p.)

给药途径
Intra-arterial injection, i.p.
参考文献

动物研究
剂量	Cat: 0.35 mg/kg - 1 mg/kg^[3] (intra-arterial injection) Mice: 330 mg/kg^[4] (i.p.), 10 mg/kg^[5] (i.p.)
给药途径	Intra-arterial injection, i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3251 mL
- 11.6256 mL
- 23.2513 mL
- 5 mM
- 0.4650 mL
- 2.3251 mL
- 4.6503 mL
- 10 mM
- 0.2325 mL
- 1.1626 mL
- 2.3251 mL

技术信息

CAS号

76939-46-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H10BrN5NaO6P

运输

蓝冰

分子量

430.08

别名

8-Br-Camp sodium salt;8-bromo-Cyclic AMP (sodium salt);8-Bromoadenosine 3',5'-cyclic monophosphate;8-bromo-cAMP;8-Br-cAMP sodium;8-Br-cAMP Na

溶解度

DMSO	240.0 mg/mL (558.0 mM)
Water	insoluble

动物实验配方

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8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt/5'-环单磷酸钠 Catalog No. CSN10180

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