|9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-3H-嘌呤-6(9H)-酮|CsnPharm

CAS No.: 58-63-9

肌苷 Catalog No. CSN23573

Synonyms: NSC 20262;INO 495;9-β-D-Ribofuranosylhypoxanthine

Inosine is an endogenous purine nucleoside with immunomodulatory, neuroprotective, and analgesic properties.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Inosine, a naturally occurring purine nucleoside, has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models^[1]. Inosine-mediated A2AR activation leads to cAMP production with an EC50 of 300.7 μM and to extracellular signal-regulated kinase-1 and -2 (ERK1/2) phosphorylation with an EC50 of 89.38 μM. Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation^[2]. The administration of inosine exerted neuroprotective effects against EAE (experimental autoimmune encephalomyelitis) by diminishing clinical signs, including thermal and mechanical hyperalgesia, as well as weight loss typical of the disease. Up-regulation of IL-17 levels in the secondary lymphoid tissues, a result of EAE, was prevented by inosine treatment in EAE mice. Additionally, inosine consistently prevented A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. Graphical Abstract Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. Furthermore, neuroinflammation and demyelinating processes were blocked by inosine treatment^[3].
参考文献

[1] Moore TL, Pessina MA, Finklestein SP, et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016;34(5):827-848
[2] Welihinda AA, Kaur M, Greene K, Zhai Y, Amento EP. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016;28(6):552-560
[3] Junqueira SC, Dos Santos Coelho I, Lieberknecht V, et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2017;54(5):3271-3285

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7281 mL
- 18.6407 mL
- 37.2814 mL
- 5 mM
- 0.7456 mL
- 3.7281 mL
- 7.4563 mL
- 10 mM
- 0.3728 mL
- 1.8641 mL
- 3.7281 mL

技术信息

CAS号

58-63-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H12N4O5

运输

蓝冰

分子量

268.23

别名

NSC 20262;INO 495;9-β-D-Ribofuranosylhypoxanthine;肌苷

溶解度

DMSO	25.0 mg/mL (93.2 mM) warming
Water	10.0 mg/mL (37.3 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

肌苷 Catalog No. CSN23573

靶点选择性

请登录您的专属账户

确认信息