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CAS No.: 91421-43-1

9-Aminocamptothecin/9-氨基喜树碱 Catalog No. CSN13080

Synonyms: 9-amino-20(S)-camptothecin;9-amino Camptothecin;NSC 603071

9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.

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实验方案

技术信息

生物活性

描述9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00003551	Kidney Cancer	Phase 2	Completed	-	United States, Georgia ... more >> Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 Emory University School of Medicine Atlanta, Georgia, United States, 30322 Collapse <<
NCT00003523	Ovarian Cancer ... more >> Primary Peritoneal Cavity Cancer Collapse <<	Phase 2	Completed	-	-
NCT00002635	Lymphoma	Phase 2	Completed	-	United States, Connecticut ... more >> Yale Comprehensive Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Illinois Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts New England Medical Center Hospital Boston, Massachusetts, United States, 02111 Collapse <<

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参考文献

[1] Maier-Salamon A, Thalhammer T, et al. Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86.
[2] Gao SQ, Sun Y, et al. Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromol Biosci. 2009 Nov 10;9(11):1135-42.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7520 mL
- 13.7602 mL
- 27.5204 mL
- 5 mM
- 0.5504 mL
- 2.7520 mL
- 5.5041 mL
- 10 mM
- 0.2752 mL
- 1.3760 mL
- 2.7520 mL

技术信息

CAS号

91421-43-1

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H17N3O4

运输

蓝冰

分子量

363.37

别名

9-amino-20(S)-camptothecin;9-amino Camptothecin;NSC 603071;9AC;Aminocamptothecin;9-氨基喜树碱;9-Amino-CPT

溶解度

DMSO	25.0 mg/mL (68.8 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00003551	Kidney Cancer	Phase 2	Completed	-	United States, Georgia ... more >> Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 Emory University School of Medicine Atlanta, Georgia, United States, 30322 Collapse <<
NCT00003523	Ovarian Cancer ... more >> Primary Peritoneal Cavity Cancer Collapse <<	Phase 2	Completed	-	-
NCT00002635	Lymphoma	Phase 2	Completed	-	United States, Connecticut ... more >> Yale Comprehensive Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Illinois Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts New England Medical Center Hospital Boston, Massachusetts, United States, 02111 Collapse <<
NCT00003154	Lung Cancer	Phase 2	Completed	-	United States, Ohio ... more >> Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Collapse <<
NCT02646189	Hepatitis B, Chronic	Phase 1 Phase 2	Completed	-	Bangladesh ... more >> Farabi General Hospital Dhaka, Bangladesh, 1213 Collapse <<
NCT00002745	Lymphoma	Phase 2	Completed	-	United States, District of Col... more >>umbia Walter Reed Army Medical Center Washington, District of Columbia, United States, 20307-5000 United States, Minnesota University of Minnesota Cancer Center Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University Barnard Cancer Center Saint Louis, Missouri, United States, 63110 United States, New Jersey Cooper Cancer Institute Camden, New Jersey, United States, 08103 St. Joseph's Hospital and Medical Center Paterson, New Jersey, United States, 07503 Collapse <<
NCT00003192	Esophageal Cancer ... more >> Gastric Cancer Collapse <<	Phase 2	Completed	-	United States, Illinois ... more >> University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Cancer Care Specialists of Central Illinois, S.C. Decatur, Illinois, United States, 62526 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46617 Collapse <<
NCT00251368	Leukemia, Myelocytic, Acute ... more >> Acute Lymphocytic Leukemia Collapse <<	Phase 1	Completed	-	United States, Massachusetts ... more >> Massachusetts General Hosptial Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse <<
NCT00002671	Ovarian Cancer	Phase 2	Completed	-	United States, New Jersey ... more >> Riverview Medical Center Red Bank, New Jersey, United States, 07701 Overlook Hospital Summit, New Jersey, United States, 07902-0220 United States, New York Albert Einstein Comprehensive Cancer Center Bronx, New York, United States, 10461 NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 New York Presbyterian Hospital - Cornell Campus New York, New York, United States, 10021 Mount Sinai Medical Center, NY New York, New York, United States, 10029 Collapse <<
NCT00001427	Ovarian Neoplasms	Phase 2	Completed	-	United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse <<
NCT02646163	Hepatitis B, Chronic	Phase 1 Phase 2	Completed	-	Bangladesh ... more >> Farabi General Hospital Dhaka, Bangladesh, 1213 Collapse <<

9-Aminocamptothecin/9-氨基喜树碱 Catalog No. CSN13080

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