|(2R,3R,4S,5S,6S)-5-氨基-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-氨基-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-二氨基-2,3-二羟环己基)氧基)-4-羟基-3-（甲胺基）八氢吡喃并[3,2-b]吡喃-2-基）氧基）-6-（羟甲基）四氢-2H-吡喃-3,4-二醇硫酸盐|CsnPharm

CAS No.: 410097-64-2

(2R,3R,4S,5S,6S)-5-Amino-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate Catalog No. CSN10323

Synonyms: Apramycin sulfate

Apramycin sulfate is an aminoglycoside antibiotic and has a bactericidal action against many Gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.

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描述Apramycin (sulfate) is a structurally unique aminoglycoside. In vitro, apramycin shows broad-range antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. Apramycin also shows high antimycobacterial activity. The MIC of M. tuberculosis Erdman is 1.5 mg/liter for both apramycin and the comparator amikacin. In animals infected with methicillin-resistant S. aureus (Staphylococcus aureus), treatment with apramycin reduced the bacterial burden both in blood and in kidney^[3]. Moreover, it has proved that in vitro activity of apramycin against clinical strains of vancomycin-intermediate and methicillin-resistant and -suseptible Staphylococcus aureus. Apramycin demonstrated an MIC50/MIC90 of 8/16 µg/mL^[4]. The use of apramycin may lead to enhanced spread of gentamicin-resistant E. coli^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5683 mL
- 7.8413 mL
- 15.6826 mL
- 5 mM
- 0.3137 mL
- 1.5683 mL
- 3.1365 mL
- 10 mM
- 0.1568 mL
- 0.7841 mL
- 1.5683 mL

技术信息

CAS号	410097-64-2	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H43N5O15S	运输	蓝冰
分子量	637.65	别名	Apramycin sulfate

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(2R,3R,4S,5S,6S)-5-Amino-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate Catalog No. CSN10323

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