|(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(二甲基氨基)-3,5-二羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-7-(2-((3R,5S)-3,5-二甲基哌啶-1-基)乙基)-16-乙基-4-羟基-15-((((2R,3R,4R,5R,6R)-5-羟基-3,4-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基)-5,9,13-三甲基氧杂环十六烷-11,13-二烯-2,10-二酮|CsnPharm

CAS No.: 108050-54-0

替米考星 Catalog No. CSN12092

Synonyms: 替米考星;LY-177370;EL-870

Tilmicosin is a macrolide antibiotic developed for veterinary use, working by inhibiting protein synthesis in bacteria with IC50 value of 0.36 µM.

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技术信息

生物活性

描述Tilmicosin is a widely used antibiotic in veterinary applications. Its antimicrobial activity is ranged from Gram-positive and some Gram-negative bacteria towards activities against Mycoplasma and Chlamydia^[3]. The MIC90 of tilmicosin against Haemophilus parasuis, Actinbacillus pleuropneumoniae, and Pasteurella multocida were all 8 μg/ml. The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC0-t values^[4]. Tilmicosin is used to treat intramammary infections against Staphylococcus aureus and has clinical anti-inflammatory effects. Tilmicosin decreases intracellular infection and had a protective effect on MAC-T (immortalized mammary epithelial cells) reducing apoptosis after infection by 80%. Furthermore, tilmicosin reduced reactive oxygen species (ROS), IL-1β, IL-6, and TNF-αproduction. The anti-inflammatory effect of tilmicosin helped to preserve casein synthesis in mammary epithelial cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1506 mL
- 5.7529 mL
- 11.5057 mL
- 5 mM
- 0.2301 mL
- 1.1506 mL
- 2.3011 mL
- 10 mM
- 0.1151 mL
- 0.5753 mL
- 1.1506 mL

技术信息

CAS号

108050-54-0

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C46H80N2O13

运输

蓝冰

分子量

869.13

别名

替米考星;LY-177370;EL-870

溶解度

DMSO	25.0 mg/mL (28.8 mM)
Water	10.0 mg/mL (11.5 mM)

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