CAS No.: 15291-77-7
银杏内酯 B Catalog No. CSN12569
Synonyms: BN-52021;Bilobalide B;BN-52051
Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, a PAFR antagonist with IC50 of 3.6 μM, is reported to increase cell viability and decrease cell apoptosis.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 PAFR
IC50:3.6μM- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03772847 Intravenous Alteplase Thrombol... more >>ysis Neurological Improving Collapse << Phase 4 Recruiting December 1, 2019 China, Zhejiang ... more >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen 13757118366 HREC2013@126.com Collapse << NCT02425436 Intrauterine Growth Restrictio... more >>n (IUGR) Collapse << Phase 2 Completed - - - 参考文献
- [1] Jean R. Rapin, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research, 1998, 45 (1):1-43
- [2] Lamant V, Mauco G, et al. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol. 1987 Sep 1;36(17):2749-52.
- [3] Hu H, Li Y, Xin Z, Zhanga X. Ginkgolide B exerts anti-inflammatory and chondroprotective activity in LPS-induced chondrocytes. Adv Clin Exp Med. 2018 Jul;27(7):913-920
- [4] Wang G, Liu Z, Li M, Li Y, Alvi SS, Ansari IA, Khan MS. Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality. Biomed Res Int. 2019 Jun 10;2019:7284767
- [5] Zhang M, Sun J, Chen B, Zhao Y, Gong H, You Y, Qi R. Ginkgolide B inhibits platelet and monocyte adhesion in TNFα-treated HUVECs under laminar shear stress. BMC Complement Altern Med. 2018 Jul 20;18(1):220
- [6] In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons
- [7] Zheng PD, Mungur R, Zhou HJ, Hassan M, Jiang SN, Zheng JS. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13(7):1204-1211
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 15291-77-7 | 储存条件 |
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| 分子式 | C20H24O10 | 运输 | 蓝冰 | |||||||
| 分子量 | 424.40 | 别名 | BN-52021;Bilobalide B;BN-52051;银杏内酯B | |||||||
| 溶解度 |
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动物实验配方 |
