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CAS No.: 1258226-87-7

奥比他韦 Catalog No. CSN15769

Synonyms: ABT-267;Viekira Pak;奥比他韦

Ombitasvir is inhibitor of hepatitis C virus protein NS5A with EC50s of 0.82 pM to 19.3 pM against HCV genotypes 1 to 5.

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技术信息

生物活性

描述Hepatitis C virus (HCV) is an enveloped, single-stranded, positive-sense RNA virus in the Flaviviridae family. Ombitasvir is a HCV NS5A inhibitor with pan-genotypic activity. Ombitasvir had EC₅₀s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 sub-genomic replicons, respectively. It demonstrated broad genotypic activity, with EC₅₀s of 0.82 to 19.3 pM against genotype 2a, 2b, 3a, 4a, and 5a replicons and 366 pM against a genotype 6a replicon. Among a panel of HCV genotype 1 to 6 isolates, the EC₅₀ of ombitasvir ranged from 0.1 to15.1 pM against NS5A from 66 genotype 1 to 5 isolates. In addition, ombitasvir was active against the genotype 2a JFH-1 replicon, with an EC₅₀ of 0.82 pM. In a 3-day monotherapy study (5, 25, 50, or 200 mg; once daily) in 12 HCV genotype 1-infected patients, decreases in HCV RNA up to 3.1 log10 IU/ml were observed. And wild-type virus was largely suppressed by ombitasvir during 3-day monotherapy, and at doses higher than 5 mg, resistant variant M28V was also suppressed^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02446717	Chronic Hepatitis C ... more >> Hepatitis C Virus HCV Direct-Acting Antiviral Agent (DAA)-Experienced Collapse <<	Phase 2 Phase 3	Completed	-	-
NCT03423641	-	-	Completed	-	-
NCT02333292	-	-	Recruiting	December 2020	Spain ... more >> Valme University Hospital Recruiting Seville, Andalusia, Spain, 41014 Contact: Karin I Neukam, Dr 0034955015871 karin.neukam@gmail.com Contact: Juan A Pineda, Dr 0034955015684 japineda@telefonica.net Collapse <<

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参考文献

[1] Krishnan P, Beyer J, et al. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob Agents Chemother. 2015 Feb;59(2):979-87.
[2] DeGoey DA, Randolph JT, et al. Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57.
[3] Krishnan P, Beyer J, Mistry N, Koev G, Reisch T, DeGoey D, Kati W, Campbell A, Williams L, Xie W, Setze C, Molla A, Collins C, Pilot-Matias T. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob Agents Chemother. 2015 Feb;59(2):979-87

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1184 mL
- 5.5922 mL
- 11.1843 mL
- 5 mM
- 0.2237 mL
- 1.1184 mL
- 2.2369 mL
- 10 mM
- 0.1118 mL
- 0.5592 mL
- 1.1184 mL

技术信息

CAS号

1258226-87-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C50H67N7O8

运输

蓝冰

分子量

894.11

别名

ABT-267;Viekira Pak;奥比他韦

溶解度

DMSO	100.0 mg/mL (111.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02446717	Chronic Hepatitis C ... more >> Hepatitis C Virus HCV Direct-Acting Antiviral Agent (DAA)-Experienced Collapse <<	Phase 2 Phase 3	Completed	-	-
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NCT02333292	-	-	Recruiting	December 2020	Spain ... more >> Valme University Hospital Recruiting Seville, Andalusia, Spain, 41014 Contact: Karin I Neukam, Dr 0034955015871 karin.neukam@gmail.com Contact: Juan A Pineda, Dr 0034955015684 japineda@telefonica.net Collapse <<
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NCT02634008	Hepatitis C, Acute	Phase 3	Recruiting	December 2022	Australia, New South Wales ... more >> St Vincent's Hospital Recruiting Sydney, New South Wales, Australia, 2010 Contact: Rebecca Hickey +61 2 8382 4981 rhickey@stvincents.com.au Principal Investigator: Gregory Dore, MBS PhD Sub-Investigator: Gail Matthews, MBBS PhD Australia, South Australia Royal Adelaide Hospital Recruiting Adelaide, South Australia, Australia, 5000 Contact: Catherine Ferguson +61 8 8222 5635 catherine.ferguson@health.sa.gov.au Principal Investigator: David Shaw Australia, Victoria Alfred Hospital Recruiting Melbourne, Victoria, Australia, 3004 Contact: Michelle Hagenauer 03-9282 2261 gaclinresearch@alfred.org.au Principal Investigator: Margaret Hellard New Zealand Auckland City Hospital Recruiting Auckland, Grafton, New Zealand, 1023 Contact: Victoria Oliver +64 9 307 4949 ext 22917 VictoriaOl@adhb.govt.nz Principal Investigator: Ed Gane, MD FRACP United Kingdom Barts and London Recruiting London, United Kingdom, EC1A 7BE Contact: Chloe Orkin, MBBCh FRCP chloe.orkin@bartshealth.nhs.uk Principal Investigator: Chloe Orkin, MBBCh FRCP Royal Free Hospital Recruiting London, United Kingdom, NW3 2QG Contact: Sanjay Bhagani, MBChB +44 20 7794 0500 ext 36285 s.bhagani@nhs.net Principal Investigator: Sanjay Bhagani, MBChB Guy's and St Thomas' Hospital Recruiting London, United Kingdom, SE1 7EH Contact: Ranjababu Kulasegeram gpliaisonlbh@hcahealthcare.co.uk Principal Investigator: Ranjababu Kulasegeram Chelsea and Westminster Hospital Recruiting London, United Kingdom, SW10 9NH Contact: Mark Nelson, MD +442087465610 m.nelson@ic.ac.uk Principal Investigator: Mark Nelson, MD St Mary's Hospital Recruiting London, United Kingdom, W2 1NY Contact: Graham Cooke g.cooke@imperial.ac.uk Principal Investigator: Graham Cooke Collapse <<
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NCT02461745	Hepatitis C, Chronic	Phase 4	Active, not recruiting	July 2018	United States, California ... more >> Kaiser Permanente Medical Center Irvine, California, United States, 92618 Kaiser Permanente Medical Center Los Angeles, California, United States, 90027 Kaiser Permanente Medical Center San Diego, California, United States, 92154 Kaiser Permanente Medical Center San Marcos, California, United States, 92078 Collapse <<
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NCT02817594	-	-	Completed	-	Netherlands ... more >> Noordwest Ziekenhuisgroep Alkmaar, Netherlands, 1815 JD OLVG Locatie West Amsterdam, Netherlands, 1061 AE Vrije Univ Medisch Centrum Amsterdam, Netherlands, 1081 HV Albert Schweitzer Ziekenhuis Dordrecht, Netherlands, 3318 AT Catharina ziekenhuis Eindhoven, Netherlands, 5623 Univ Med Center Groningen Groningen, Netherlands, 9713 GZ Leids Universitair Medisch Cen Leiden, Netherlands, 2333 ZA Maastricht University Med Ctr Maastricht, Netherlands, 6229 HX Radbound University Medical Ce Nijmegen, Netherlands, 6526 GA Erasmus Medisch Centrum Rotterdam, Netherlands, 3015 CE Maasstad Ziekenhuis Rotterdam, Netherlands, 3079 DZ UMC Utrecht Utrecht, Netherlands, 3584 CX Collapse <<
NCT01716585	-	-	Completed	-	-
NCT02725866	-	-	Completed	-	Greece ... more >> General University Hospital of Alexandroupolis /ID# 149494 Alexandroupolis, Greece, 68100 General University Hospital of Alexandroupolis /ID# 153776 Alexandroupolis, Greece, 68100 Evangelismos General Hospital of Athens /ID# 151259 Athens, Greece, 10676 General Hospital of Athens, Evangelismos /ID# 149510 Athens, Greece, 10676 General Hospital of Athens "Ippokratio" /ID# 151260 Athens, Greece, 11527 General Hospital of Athens "Laiko" /ID# 149498 Athens, Greece, 11527 General and Oncology Hospital of Kifisia Agioi Anargyroi /ID# 149509 Athens, Greece, 14564 Iasso General Hospital /ID# 149503 Athens, Greece, 15562 University General Hospital of Heraklion /ID# 151436 Heraklion, Greece, 71500 University General Hospital of Ioannina /ID# 151257 Ionnina, Greece, 45500 Regional General University Hospital of Larissa /ID# 151255 Larisa, Greece, 41111 Mitera Private Hospital /ID# 149504 Marousi, Greece, P.C.15123 Regional General University Hospital of Patras /ID# 151258 Patras, Greece, 26504 Agios Panteleimon General Hospital of Nikea /ID# 149507 Pireaus, Greece, 18454 Agios Panteleimon General Hospital of Nikea /ID# 149508 Pireaus, Greece, 18454 General Hospital of Piraeus "Tzaneio" /ID# 149506 Pireaus, Greece, 18536 General Hospital of Rhodes /ID# 151256 Rhodes, Greece, 85100 Bioclinic Thessaloniki /ID# 149497 Thessaloniki, Greece, 54622 University General Hospital "AHEPA" /ID# 149505 Thessaloniki, Greece, 54636 University General Hospital "AHEPA" /ID# 153774 Thessaloniki, Greece, 54636 General Hospital of Thessaloniki Papageorgiou /ID# 149495 Thessaloniki, Greece, 56429 Interbalkan Center of Thessaloniki /ID# 149496 Thessaloniki, Greece, 57001 Collapse <<
NCT02052362	Absolute Bioavailability	Phase 1	Completed	-	United Kingdom ... more >> Site Reference ID/Investigator# 118615 Nottingham, United Kingdom, NG11 6JS Collapse <<
NCT02798315	-	-	Completed	-	Kuwait ... more >> Adan Hospital /ID# 150776 Adan, Kuwait Mubarak Hospital /ID# 150772 Hawalli, Kuwait Mubarak Hospital /ID# 150773 Hawalli, Kuwait Mubarak Hospital /ID# 150774 Hawalli, Kuwait Amiri Hospital /ID# 150775 Kuwait, Kuwait Collapse <<
NCT01685203	-	-	Completed	-	-
NCT01458535	Hepatitis C Virus	Phase 2	Completed	-	-
NCT01458535	-	-	Completed	-	-
NCT01939197	-	-	Completed	-	-
NCT01833533	Chronic Hepatitis C Infection	Phase 3	Completed	-	-
NCT03053180	-	-	Completed	-	Russian Federation ... more >> South-Ural State Med. Academy Chelyabinsk, Russian Federation, 454052 KOGBUZ Kirovsk Infect Hosp Kirov, Russian Federation, 610008 Specialized Clinical Infectiou Krasnodar, Russian Federation, 350000 Orenburg Regional Clinical Hos Orenburg, Russian Federation, 460018 LLC Medical Company Samara, Russian Federation, 443063 GBOU VPO Saratov State Med Uni Saratov, Russian Federation, 410012 Ulyanovsk Regional Clin Hosp Ulyanovsk, Russian Federation, 432018 Collapse <<
NCT01685203	Hepatitis C, Chronic	Phase 2	Completed	-	-
NCT01833533	-	-	Completed	-	-
NCT03002818	-	-	Completed	-	Switzerland ... more >> Kantonsspital St. Gallen St. Gallen, Sankt Gallen, Switzerland, 9007 Inselspital, Universitaetsklin Bern, Switzerland, 3010 Fondazione Epatocentro Ticino Lugano, Switzerland, 6900 Hopital Neuchatelois Neuchatel, Switzerland, CH-2000 Universitaetsspital Zuerich Zurich, Switzerland, 8091 Collapse <<
NCT02851069	-	-	Completed	-	Colombia ... more >> Fundacion Cardioinfantil /ID# 155724 Bogota, Colombia Cic Cali /Id# 163986 Cali, Colombia, 760001 Centro Medico Imbanaco de Cali /ID# 163660 Cali, Colombia Pharos Centro de Estudios Clin /ID# 161709 Cartagena, Colombia, 130013 IPS Medicos Internistas Del Ca /ID# 163987 Manizales, Colombia, 170004 Fundacion Hospitalaria San Vin /ID# 167437 Medellín, Colombia, 050010 Collapse <<
NCT02498015	Hepatitis C, Chronic	Phase 4	Active, not recruiting	September 2020	Australia, New South Wales ... more >> The Kirby Institute, University of New South Wales Australia Sydney, New South Wales, Australia, 2052 Collapse <<
NCT02517528	Chronic Hepatitis C Virus (HCV... more >>) Collapse <<	Phase 3	Completed	-	-
NCT02517528	-	-	Completed	-	-
NCT01767116	Chronic Hepatitis C Infection	Phase 3	Completed	-	-
NCT02216422	Chronic Hepatitis C Virus (HCV... more >>) Infection Collapse <<	Phase 3	Completed	-	-
NCT03067883	Chronic Hepatitis c	Phase 2	Recruiting	July 2018	Egypt ... more >> Maadi armed forces hospital Recruiting Cairo, Maadi, Egypt Contact: Maadi armed forces hospital 002025265127 Collapse <<
NCT02216422	-	-	Completed	-	-
NCT02023112	Hepatitis C Virus	Phase 3	Completed	-	-
NCT02442271	-	-	Completed	-	-
NCT02265237	Hepatitis C Virus	Phase 3	Completed	-	-
NCT01767116	-	-	Completed	-	-
NCT02023112	-	-	Completed	-	-
NCT02442271	Chronic Hepatitis C Infection	Phase 3	Completed	-	-
NCT02207088	Chronic Hepatitis C ... more >> Hepatitis C Virus Compensated Cirrhosis Severe Renal Impairment End-stage Renal Disease Collapse <<	Phase 3	Completed	-	-
NCT02265237	-	-	Completed	-	-
NCT02207088	-	-	Completed	-	-
NCT01672983	Chronic Hepatitis C Infection	Phase 2	Completed	-	-
NCT02640547	-	-	Completed	-	-
NCT02669940	-	-	Completed	-	-
NCT02356562	Chronic Hepatitis C Infection	Phase 2	Completed	-	-
NCT02669940	-	-	Completed	-	-
NCT01672983	-	-	Completed	-	-
NCT02640547	-	-	Completed	-	-
NCT02356562	-	-	Completed	-	-
NCT02219477	Chronic Hepatitis C ... more >> Decompensated Cirrhosis Hepatitis C Virus Collapse <<	Phase 3	Completed	-	-
NCT02534870	Healthy Volunteer	Phase 1	Completed	-	China ... more >> Site Reference ID/Investigator# 137655 Shanghai, China, 200031 Collapse <<
NCT01674725	Chronic Hepatitis C Infection	Phase 3	Completed	-	-
NCT01674725	-	-	Completed	-	-
NCT02219477	-	-	Completed	-	-
NCT01314261	Chronic Hepatitis C ... more >> Hepatitis C Virus (HCV) Infection Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Site Reference ID/Investigator# 56623 Birmingham, Alabama, United States, 35215 United States, California Site Reference ID/Investigator# 48476 Los Angeles, California, United States, 90048 United States, Florida Site Reference ID/Investigator# 51345 Orlando, Florida, United States, 32809 United States, Hawaii Site Reference ID/Investigator# 51498 Honolulu, Hawaii, United States, 96814 United States, Indiana Site Reference ID/Investigator# 48473 Indianapolis, Indiana, United States, 46202 United States, Missouri Site Reference ID/Investigator# 52782 Kansas City, Missouri, United States, 64131 United States, Texas Site Reference ID/Investigator# 48471 Houston, Texas, United States, 77030 Site Reference ID/Investigator# 48474 San Antonio, Texas, United States, 78215 United States, Virginia Site Reference ID/Investigator# 48477 Fairfax, Virginia, United States, 22031 United States, Washington Site Reference ID/Investigator# 48472 Seattle, Washington, United States, 98101 Puerto Rico Site Reference ID/Investigator# 48483 San Juan, Puerto Rico, 00927 Collapse <<
NCT01563536	Chronic Hepatitis C Infection	Phase 2	Completed	-	United States, California ... more >> Site Reference ID/Investigator# 68002 Bakersfield, California, United States, 93301 United States, Florida Site Reference ID/Investigator# 67383 Orlando, Florida, United States, 32809 United States, Maryland Site Reference ID/Investigator# 67382 Annapolis, Maryland, United States, 21401 United States, New York Site Reference ID/Investigator# 67385 Poughkeepsie, New York, United States, 12601 Collapse <<
NCT02493855	Chronic Hepatitis C ... more >> Hepatitis C (HCV) Hepatitis C Genotype 1a Collapse <<	Phase 2	Completed	-	-
NCT01563536	-	-	Completed	-	-
NCT01911845	Chronic Hepatitis C Infection ... more >> Chronic Hepatitis C Collapse <<	Phase 2	Completed	-	-
NCT01314261	-	-	Completed	-	-
NCT02734173	Hepatitis C	Phase 4	Recruiting	December 2018	Canada, Ontario ... more >> The Ottawa Hospital, General Campus Recruiting Ottawa, Ontario, Canada Contact: Curtis Cooper, MD 613-737-8924 Principal Investigator: Curtis Cooper, MD Collapse <<
NCT01911845	-	-	Completed	-	-
NCT02493855	-	-	Completed	-	-
NCT02504099	Chronic Hepatitis C Infection	Phase 3	Terminated(Study stopped due t... more >>o low enrollment) Collapse <<	-	-
NCT02442284	-	-	Completed	-	-
NCT02517515	Hepatitis C Virus (HCV)	Phase 3	Completed	-	-
NCT02504099	-	-	Terminated(Study stopped due t... more >>o low enrollment) Collapse <<	-	-
NCT02442284	Chronic Hepatitis C ... more >> Cirrhosis Hepatitis C Virus Collapse <<	Phase 3	Completed	-	-
NCT01704755	Chronic Hepatitis C Infection ... more >> Compensated Cirrhosis Collapse <<	Phase 3	Completed	-	-
NCT02609659	Hepatitis C Virus (HCV)	Phase 3	Completed	-	-
NCT02609659	-	-	Completed	-	-
NCT01704755	-	-	Completed	-	-
NCT02517515	-	-	Completed	-	-
NCT03499639	End-stage Renal Disease ... more >> HCV Coinfection Collapse <<	Phase 4	Recruiting	December 30, 2018	Egypt ... more >> Assiut University Hopsital Recruiting Assiut, Egypt, 71515 Contact: Mohamed A Mekky, MD Collapse <<
NCT02399345	Chronic Hepatitis C Virus (HCV... more >> Infection Genotype 1) Collapse <<	Phase 3	Completed	-	-
NCT02806362	Chronic Hepatitis C Virus	Phase 3	Withdrawn(Study halted prematu... more >>rely, prior to enrollment of first participant) Collapse <<	August 2018	-
NCT03341988	Hepatitis C	Phase 1	Completed	-	Egypt ... more >> Assiut University Assiut, Egypt Collapse <<
NCT03122132	-	-	Completed	-	Spain ... more >> Carrion, Jose Antonio, PhD Barcelona, Spain, 08003 Collapse <<
NCT02582632	Hepatitis C Infection ... more >> Hepatitis C Virus Collapse <<	Phase 3	Completed	-	-
NCT02476617	Chronic Hepatitis C ... more >> Hepatitis C (HCV) Hepatitis C Genotype 1a Collapse <<	Phase 3	Completed	-	-
NCT02582632	-	-	Completed	-	-
NCT02487199	Hepatitis C Virus (HCV)	Phase 3	Completed	-	-
NCT02219503	-	-	Completed	-	-
NCT02476617	-	-	Completed	-	-
NCT02399345	-	-	Completed	-	-
NCT02487199	-	-	Completed	-	-
NCT02219503	Chronic Hepatitis C Infection ... more >> Compensated Cirrhosis Collapse <<	Phase 3	Completed	-	-

奥比他韦 Catalog No. CSN15769

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