|(10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-氨基-1-羟丙基)-12-((2-氨基乙基)氨基)-23-((1S,2S)-1,2-二羟基-2-(4-羟基苯基)乙基)-2,11,15-三羟基-6-((R)-1- 羟乙基)-5,8,14,19,22,25-六氧代二十四氢-1H-二吡咯并[2,1-c:2',1'-l][1,4,7,10,13,16]六氮杂cyclohenicosin-9-基)-10,12-二甲基十四酰胺二乙酸盐|CsnPharm

CAS No.: 179463-17-3

醋酸卡泊芬净 Catalog No. CSN15933

Synonyms: MK-0991 diacetate;L-743872 diacetate;MK-0991

Caspofungin acetate is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.

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生物活性

描述Caspofungin acetate (Diacetate) is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. Extended incubation of A. fumigatus with a single dose of caspofungin affected the same proportion of apical and subapical branching cells for up to 72 h. The dye-staining patterns illustrate that the cells at the active centers for new cell wall synthesis within A. fumigatus hyphae are killed when they are exposed to caspofungin^[3]. Caspofungin (CPFG) showed an excellent effect against FN (febrile neutropenia) (75%, 18/24), without any serious hepatic or renal toxicity. The high efficacy, safety, and tolerability of CPFG as an empirical antifungal therapy for Japanese patients with FN^[4]. Caspofungin may be considered as a component of combination antifungal regimens. Caspofungin represents a significant advance in the care of patients with serious fungal infections^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8241 mL
- 4.1206 mL
- 8.2412 mL
- 5 mM
- 0.1648 mL
- 0.8241 mL
- 1.6482 mL
- 10 mM
- 0.0824 mL
- 0.4121 mL
- 0.8241 mL

技术信息

CAS号

179463-17-3

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C56H96N10O19

运输

蓝冰

分子量

1213.42

别名

MK-0991 diacetate;L-743872 diacetate;MK-0991;L-743872;Caspofungin (acetate);L-743,872;Caspofungin acetate;brand name: Cancidas;二醋酸卡泊芬净

溶解度

DMSO	135.0 mg/mL (111.3 mM)
Water	180.0 mg/mL (148.3 mM)

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