|(2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5S,6R)-4,5-二羟基-2-(((3R,6R)-2-羟基-6-((3S,8S,9R,10R,11R,13R,14S,17R)-11-羟基-4,4,9,13,14-五甲基-3-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊[a]菲-17-基)-2-甲基庚-3-基)氧基)-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-yl)氧基)甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 88901-36-4

罗汉果皂苷V Catalog No. CSN16048

Synonyms: 罗汉果苷 V;罗汉果甜苷 V;罗汉果甙 V

Mogroside V, a natural product isolated and purified from the fruit of Siraitia grosvenorii Swingle., has a significant effect on insulin secretion, and helps control blood sugar levels and contribute in management of diabetes and obesity.

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技术信息

生物活性

描述Mogroside V (MV) is a triterpenoid glycoside and a nonsugar sweetener. MV significantly ameliorated hepatic steatosis in high-fat diet- (HFD-) fed mice. Furthermore, the increased protein expression of PPAR-γ, SREBP-1, and FASN and mRNA expression of pparg, srebp1, scd1, and fasn in the liver in HFD-fed mice, which contribute to de novo lipogenesis, were dose-dependently reversed by MV treatment^[3]. Mogroside V can effectively maintain normal oocyte morphology and early embryo development competence after prolonged culture for 24 h. Moreover, mogroside V can markedly reduce reactive oxygen species (ROS) levels, alleviate spindle formation and chromosome alignment abnormalities, improve mitochondrial contents, adenosine triphosphate (ATP) levels and the membrane potential (ΔΨm), and reduce early apoptosis in aged oocytes^[4]. MV can protect oocytes from LPS-induced meiotic defects in part by reducing oxidative stress and maintaining m6A levels^[5]. MV might alleviate oocyte meiotic defects and quality deterioration in BaP (benzo(a)pyrene)-exposed mice^[6]. Mog (Mogroside V) might play a protective role against LPS-induced neurotoxicity by inhibiting the TLR4(toll-like receptor 4)-MyD88 (myeloid differentiation factor 88) and activation of AMPK/AKT-Nrf2 signaling pathway^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.7767 mL
- 3.8837 mL
- 7.7674 mL
- 5 mM
- 0.1553 mL
- 0.7767 mL
- 1.5535 mL
- 10 mM
- 0.0777 mL
- 0.3884 mL
- 0.7767 mL

技术信息

CAS号

88901-36-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C60H102O29

运输

蓝冰

分子量

1287.43

别名

罗汉果苷 V;罗汉果甜苷 V;罗汉果甙 V;罗汉果甜甙 V;罗汉果苷ⅴ

溶解度

DMSO	380.0 mg/mL (295.2 mM)
Water	190.0 mg/mL (147.6 mM)

动物实验配方

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罗汉果皂苷V Catalog No. CSN16048

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