|(2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-羧基-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-二十氢苉-3-基)氧基)-4,5-二羟基四氢-2H-吡喃-3-基)氧基)-3,4,5-三羟基四氢-2H-吡喃-2-甲酸|CsnPharm

CAS No.: 1405-86-3

甘草酸 Catalog No. CSN16160

Synonyms: Glycyrrhizin;Glizigen;Liquorice

Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.

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生物活性

实验方案

技术信息

生物活性

描述Monoamine oxidases (MAO) are a group of enzymes that inactivate monoamine neurotransmitters and catalyze the oxidation of monoamines ingested in food. Glycyrrhizic acid (GA) is a MAO inhibitor with an IC₅₀ value of 0.16 μM^[3]. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that can be released in response to necrotic or inflammatory signals. GA is also an inhibitor of HMGB1. In HBV transgenic mouse, GA administration (10 mg/mouse) ameliorated the severity of cytotoxic T lymphocytes‐induced liver disease^[4]. GA also competitively inhibits the enzymatic activity of 11-hydroxysteroid dehydrogenase type 2 (11-HSD2). By treating rats with 60 and 120 mg/kg GA (twice a day) for 2 weeks, the level of NAD⁺-dependent 11-HSD2 activity in kidney was significantly decreased to 44% and 34%, respectively, as compared to control group. A significant reduction in renal 11-HSD2 protein and mRNA expressions was also observed in rats dosed with 120 mg/kg GA when compared to vehicle-treated group^[5].
动物研究
剂量
Rat: 15 mg/kg^[3] (p.o.), 30 mg/kg - 120 mg/kg^[2] (p.o.)

给药途径
p.o.
临床研究

动物研究
剂量	Rat: 15 mg/kg^[3] (p.o.), 30 mg/kg - 120 mg/kg^[2] (p.o.)
给药途径	p.o.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03278444	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<
NCT03550651	Mild Gingivitis ... more >> Periodontal Diseases Plaque Collapse <<	Not Applicable	Completed	-	-
NCT03274427	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2152 mL
- 6.0758 mL
- 12.1517 mL
- 5 mM
- 0.2430 mL
- 1.2152 mL
- 2.4303 mL
- 10 mM
- 0.1215 mL
- 0.6076 mL
- 1.2152 mL

技术信息

CAS号

1405-86-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C42H62O16

运输

蓝冰

分子量

822.93

别名

Glycyrrhizin;Glizigen;Liquorice;甘草酸

溶解度

DMSO	98.0 mg/mL (119.1 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (121.5 mM)

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water

10 mg/mL

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03278444	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<
NCT03550651	Mild Gingivitis ... more >> Periodontal Diseases Plaque Collapse <<	Not Applicable	Completed	-	-
NCT03274427	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<
NCT02812121	Liver Failure	Phase 2	Unknown	June 2018	-
NCT02961413	-	-	Recruiting	December 2018	China ... more >> Renji hospital Recruiting Shanghai, China Contact: Yimin Mao Collapse <<
NCT00956891	-	-	Completed	-	China, Guangdong ... more >> The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou, Guangdong, China, 510630 Collapse <<
NCT03117153	Periodontitis ... more >> Gingivitis Collapse <<	Not Applicable	Completed	-	-
NCT02251678	Plaque Psoriasis	Phase 1	Completed	-	United States, Illinois ... more >> NMFF Dermatology Clinic Chicago, Illinois, United States, 60611 NM Lake Forest Hospital/ Women's Center Lake Forest, Illinois, United States, 60045 United States, New Jersey TKL Research Fair Lawn, New Jersey, United States, 07410 United States, Ohio University Hospitals Case Medical Center / Dept of Dermatology Cleveland, Ohio, United States, 44106 Collapse <<
NCT01742702	-	-	Recruiting	December 2021	Finland ... more >> Tampere University Hospital Recruiting Tampere, Finland Contact: Ilkka Pörsti, Professor ilkka.porsti@uta.fi Principal Investigator: Ilkka Pörsti, MD, PhD, Professor University of Tampere Recruiting Tampere, Finland Contact: Ilkka Pörsti, MD, PhD, Professor ilkka.porsti@uta.fi Principal Investigator: Ilkka Pörsti, Professor Collapse <<
NCT02331745	Liver Failure ... more >> Hepatitis B Alcoholic Liver Disease Collapse <<	Phase 4	Unknown	October 2016	China ... more >> Beijing; 302 Military Hospital Recruiting Beijing, China, 100039 Contact: Jinbiao Ding, Dr. 86106693462 dingjb163@163.com Collapse <<
NCT01271296	Addison Disease	Not Applicable	Completed	-	Norway ... more >> Haukeland University Hospital, Helse-Bergen HF Bergen, Norway, 5020 Collapse <<
NCT00945568	Hepatocellular Carcinoma ... more >> Chronic Liver Disease Collapse <<	Not Applicable	Completed	-	Japan ... more >> Kochi Medical School Nankoku, Kochi, Japan, 783-8505 Kochi Medical School, Kochi University Nankoku-City, Kohasu-Okocho, Japan, 783-8505 Collapse <<
NCT03266146	Drug-induced Liver Injury,Chro... more >>nic Collapse <<	Phase 1 Phase 2	Recruiting	August 27, 2021	China ... more >> Beijing 302 hospital Recruiting Beijing, China, 100039 Contact: Zhengsheng Zou, Dr. +8601066933424 zszou302@163.com Principal Investigator: Zhengsheng Zou, Dr. Collapse <<
NCT02651350	Drug-induced Liver Injury,Chro... more >>nic Collapse <<	Phase 1 Phase 2	Active, not recruiting	December 2019	China, Beijing ... more >> Beijing 302 hospital,China Beijing, Beijing, China, 100039 Collapse <<
NCT02449109	Liver Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT02449122	Lung Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT02449135	Pancreatic Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT03306745	Polycystic Ovary Syndrome ... more >> Infertility, Female Micronutrient Deficiency Collapse <<	Not Applicable	Completed	-	Austria ... more >> Medical University of Vienna, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine Vienna, Austria, 1090 Collapse <<
NCT01342185	Chronic Hepatitis B	Phase 3	Unknown	July 2013	China, Guangdong ... more >> Nanfang Hospital GuangZhou, Guangdong, China, 510000 Collapse <<
NCT00686881	-	-	Terminated(This study was term... more >>inated due to low enrollment) Collapse <<	-	-
NCT03349008	Chronic Hepatitis b ... more >> Liver Inflammation Collapse <<	Phase 4	Not yet recruiting	May 31, 2020	-
NCT01643447	Hepatocellular Carcinoma	Not Applicable	Completed	-	China, Shanghai ... more >> Eastern Hepatobiliary Surgery Hospital Shanghai, Shanghai, China Collapse <<
NCT02473458	Acute Stroke	Phase 1 Phase 2	Completed	-	Iran, Islamic Republic of ... more >> Emergency Departement of Namazi hospital Shiraz, Fars, Iran, Islamic Republic of Collapse <<
NCT02329314	-	-	Unknown	June 2016	China, Shanghai ... more >> Shuguang Hospital Recruiting Shanghai, Shanghai, China Contact: Sun Mingyu, professor 86-21-20256526 mysun248@hotmail.com Collapse <<
NCT00686881	Hepatitis C, Chronic	Phase 3	Terminated(This study was term... more >>inated due to low enrollment) Collapse <<	-	-

甘草酸 Catalog No. CSN16160

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