生物活性

• 描述Ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the induction of apoptosis, and the inhibition of proliferation, metastasis and angiogenesis, as well as the promotion of immunity^[3]. Ginsenoside Rg3 (Rg3) is one of the key components of a frequently used herbal tonic panax ginseng for fatigue treatment. In the open field test, Rg3 significantly increased the journey distance and rearing frequency, while slowed down the rest time. Rg3 could improve exercise performance and resist fatigue possibly through elevating SIRT1 (silent information regulator of transcription 1) deacetylase activity^[4]. Ginsenoside Rg3 could attenuate (lipopolysaccharide) LPS-induced ALI (Acute lung injury) by decreasing the levels of pro-inflammatory mediators and increasing the production of anti-inflammatory cytokines^[5]. Moreover, ginsenoside Rg3 suppresses angiogenesis in developing endometrial lesions. The ginsenoside Rg3 inhibitory effect on the growth of the ectopic endometrium in EMs rats might occur through the blocking of the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway, thus halting angiogenesis and promoting the apoptosis of ectopic endometrial cells^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01951443	Arterial Stiffness, Blood Pres... more >>sure Collapse <<	Phase 1	Completed	-	Canada, Ontario ... more >> Risk Factor Modification Centre, St. Michael's Hospital Toronto, Ontario, Canada, M5B 1W8 Collapse <<
  NCT01757366	Self Efficacy	Phase 2	Unknown	December 2016	China, Hebei ... more >> Hebei Tumor Hospital Recruiting Shijiazhuang, Hebei, China, 050011 Contact: Baoen Shan    13803343508    15931166600@126.com    Principal Investigator: Wei Liu Collapse <<
  NCT01717066	Stage I Hepatocellular Carcino... more >>ma Stage II Hepatocellular Carcinoma Collapse <<	Not Applicable	Completed	-	China, Fujian ... more >> The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China, 350005 China, Guangdong Tumor Hospital,Sun Yat-san University Guangzhou, Guangdong, China, 510060 China, Heilongjiang The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China, 150001 China, Hubei Tongji Hospital,Huazhong University of Science ＆ Technology Wuhan, Hubei, China, 430032 China Zhongshan hospital,Fudan University Shanghai, China, 200032 Collapse <<

• 参考文献

• [1] Joo EJ, Chun J, et al. Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor. Chem Biol Interact. 2015 May 25;233:25-34.

  [2] Rhim H, Kim H, et al., Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. Eur J Pharmacol, 2002. 436(3): 151-8.

  [3] Sun M, Ye Y, Xiao L, Duan X, Zhang Y, Zhang H. Anticancer effects of ginsenoside Rg3 (Review). Int J Mol Med. 2017;39(3):507-518

  [4] Yang QY, Lai XD, Ouyang J, Yang JD. Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats. Toxicology. 2018;409:144-151

  [5] Yang J, Li S, Wang L, et al. Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway. Front Pharmacol. 2018;9:850.

  [6] Cao Y, Ye Q, Zhuang M, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. PLoS One. 2017;12(11):e0186520.

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