|(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-二羟基-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊并[a]菲-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 41753-43-9

人参皂苷Rb1 Catalog No. CSN19503

Synonyms: Gypenoside III;NSC 310103;(3beta12beta)20(6ObetaDGlucopyranosylbetaDglucopyranosyl)oxy12hydroxydammar24en3yl2ObetaDglucopyranosylbetaDglucopyranoside

Ginsenoside Rb1, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. with anti-oxidative damage ,anti-renal interstitial fibrosis, immunostimulatory and anticancer effects, promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway.

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生物活性

描述Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 (interleukin-1 receptor-associated kinase-1) activation and phosphorylation of NF-κB p65^[3]. Ginsenoside Rb1 exerts significant anti-obesity, anti-hyperglycemic, and anti-diabetic effects by regulating the effects of glycolipid metabolism and improving insulin and leptin sensitivities^[4]. Rb1 (Ginsenoside Rb1) ameliorated calcium deposition and VSMC (vascular smooth muscle cell) osteogenic transdifferentiation both in vivo and in vitro^[5]. Sirtuin-1 (SIRT1) was activated by Rb1 to protect HUVECs (human umbilical vein endothelial cell) from H2O2-(hydrogen peroxide) induced senescence^[6]. Ginsenoside Rb1 improved memory and cognitive ability of STZ(streptozotocin)-lesioned mice. In addition to that, ginsenoside Rb1 also relieved glucose intolerance induced by STZ injection by enhancing insulin sensitivity^[7]. Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss by reducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions^[8].
临床研究

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9015 mL
- 4.5074 mL
- 9.0147 mL
- 5 mM
- 0.1803 mL
- 0.9015 mL
- 1.8029 mL
- 10 mM
- 0.0901 mL
- 0.4507 mL
- 0.9015 mL

技术信息

CAS号

41753-43-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C54H92O23

运输

蓝冰

分子量

1109.29

别名

Gypenoside III;NSC 310103;(3beta12beta)20(6ObetaDGlucopyranosylbetaDglucopyranosyl)oxy12hydroxydammar24en3yl2ObetaDglucopyranosylbetaDglucopyranoside;人参皂苷 Rb1

溶解度

DMSO	430.0 mg/mL (387.6 mM)
Water	insoluble

动物实验配方

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