|8-(((2S,3R,4S,5S,6R)-4,5-二羟基-6-(羟甲基)-3-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-5,7-二羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 76135-82-5

牡荆素-4''-O-葡萄糖苷 Catalog No. CSN19930

Synonyms: Glucosylvitexin;牡荆素-4''-O-葡萄糖苷;4″-O-牡荆素葡萄糖苷

Vitexin-4″-O-Glucoside can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge.

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实验方案

技术信息

生物活性

描述Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. Vitexin-4″-O-Glucoside (VOG) can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge. Additionally, α half-life, β half-life, (a)CL, MRT(0→t ), MRT(0→∞ ), and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20-60 mg/kg and non-linear pharmacokinetics at lower dose^[3]. In addition, VOR (Vitexin-2"-O-rhamnoside) and VOG caused no cytotoxic effect on hADSCs (human adipose-derived stem cells) at concentrations up to 250 and 480 μm, respectively. Both VOR and VOG contribute to the protection against H2 O2 -mediated oxidative stress damage and could be safely used for a wide range of concentrations^[4]. Renal excretion was the dominant path of elimination of VOG for oral and intravenous administration in mice and biliary excretion contributed less^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6380 mL
- 8.1898 mL
- 16.3795 mL
- 5 mM
- 0.3276 mL
- 1.6380 mL
- 3.2759 mL
- 10 mM
- 0.1638 mL
- 0.8190 mL
- 1.6380 mL

技术信息

CAS号

76135-82-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H30O16

运输

蓝冰

分子量

610.52

别名

Glucosylvitexin;牡荆素-4''-O-葡萄糖苷;4″-O-牡荆素葡萄糖苷

溶解度

DMSO	100.0 mg/mL (163.8 mM)

动物实验配方

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牡荆素-4''-O-葡萄糖苷 Catalog No. CSN19930

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