|(S)-4-氨基-N-((1R,2S,3S,4R,5S)-5-氨基-2-(((2S,3R,4S,5S,6R)-4-氨基-3,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-4-(((2R,3R,4S,5S,6R)-6-(氨基甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)-3-羟基环己基)-2-羟基丁酰胺硫酸盐(5:9)|CsnPharm

CAS No.: 149022-22-0

硫酸阿米卡星 Catalog No. CSN27181

Synonyms: BAY 41-6551 sulfate;硫酸阿米卡星

Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .

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生物活性

描述The aminoglycosides serve as a useful role in the treatment of serious enterococcal, mycobacterial, and gram-negative bacillary infections. Amikacin is useful against gentamicin-resistant gram-negative bacilli and also in the treatment of infections caused by susceptible Nocardia and nontuberculous mycobacteria^[1]. Amikacin sulfate (100-1500 μM; 24 hr) caused a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD₅₀ of 453 μM. In male Fischer rats, amikacin sulfate (320 mg/kg; subcutaneous injection; 10 days) increased the chance of serious hearing loss in rats in vivo^[3].
作用机制Amikacin sulfate binds irreversibly to the 30S bacterial ribosome, and inhibits synthesis of proteins^[1].
参考文献

[1] Edson RS, et al. The aminoglycosides. Mayo Clin Proc. 1999 May;74(5):519-28
[2] Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.
[3] Kitcher SR, et al. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4627 mL
- 7.3134 mL
- 14.6267 mL
- 5 mM
- 0.2925 mL
- 1.4627 mL
- 2.9253 mL
- 10 mM
- 0.1463 mL
- 0.7313 mL
- 1.4627 mL

技术信息

CAS号	149022-22-0	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C22H45N5O17S	运输	蓝冰
分子量	683.68	别名	BAY 41-6551 sulfate;硫酸阿米卡星

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