|(2S,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-二氨基-2-(((2R,3R,4R,5S,6R)-3-氨基-6-(氨基甲基)-4,5-二羟基四氢-2H-吡喃-2-基)氧基)-6-羟基环己基)氧基)-4-羟基-2-(羟甲基)四氢呋喃-3-基)氧基)四氢-2H-吡喃-3,4-二醇三(硫酸盐)|CsnPharm

CAS No.: 4146-30-9

新霉素B硫酸盐 Catalog No. CSN27702

Synonyms: Neomycin B sulfate;Fradiomycin B sulfate;Framycetin sulphate

Neomycin B is an aminoglycoside antibiotic that can inhibit hammerhead ribozyme with a Ki of 13.5 μM.

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400-920-2911

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技术信息

生物活性

描述Neomycin B sulfate (Framycetin sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Neomycin B sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Neomycin B sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Neomycin B sulfate is sensitive to pH and an increase in pH suppresses the inhibition in other systems^[1]. 5″-azido neomycin B and Framycetin sulfate selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC (hepatocellular carcinoma) cell line^[2]. Neomycin B exhibits poor antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, while kanamycin A shows weak activity against MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE) and P. aeruginosa. Polyguanidinylation of the neomycin B-derived headgroup lowers the hydrophobic requirement of the lipid tail segment to provide broad-spectrum antibacterial activity from C16 to C12. Moreover, guanidinylation of the polycationic headgroup in neomycin B-derived cationic lipids enhances antibacterial activity against a neomycin B-, kanamycin A- and gentamicin-resistant P. aeruginosa strain, and reduces haemolytic activity^[3]. Neomycin B has been found to block the binding of HIV-1 Rev protein to its viral RNA recognition site, thereby inhibiting the production of the virus^[4].
参考文献

[1] Mikkelsen NE, Brännvall M, Virtanen A, Kirsebom LA. Inhibition of RNase P RNA cleavage by aminoglycosides. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6155-60
[2] Childs-Disney JL, Disney MD. Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma. ACS Chem Biol. 2016 Feb 19;11(2):375-80
[3] Bera S, Zhanel GG, Schweizer F. Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates. J Antimicrob Chemother. 2010 Jun;65(6):1224-7
[4] Nishizono N. [Synthesis of biomimetic analogs of neomycin B]. Yakugaku Zasshi. 2002 Jul;122(7):465-9. Japanese

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1003 mL
- 5.5013 mL
- 11.0026 mL
- 5 mM
- 0.2201 mL
- 1.1003 mL
- 2.2005 mL
- 10 mM
- 0.1100 mL
- 0.5501 mL
- 1.1003 mL

技术信息

CAS号

4146-30-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H52N6O25S3

运输

蓝冰

分子量

908.88

别名

Neomycin B sulfate;Fradiomycin B sulfate;Framycetin sulphate;Neomycin B trisulfate

溶解度

DMSO	Insoluble
Water	141.0 mg/mL (155.1 mM)
Ethanol	Insoluble

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新霉素B硫酸盐 Catalog No. CSN27702

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