|2-(4-(2-(三氟甲基)苯基)哌啶-1-甲酰胺基)苯甲酸|CsnPharm

CAS No.: 1152782-19-8

Synonyms: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

A1120 is a high-affinity non-retinoid ligand for RBP4 with Ki value of 8.3nM.

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400-920-2911

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描述Retinol-binding protein 4 (RBP4) is a serum protein that transports retinol from the liver to other tissues. A1120 is a high affinity, non-retinoid ligand for RBP4 with a K_i value of 8.3nM. The IC50 values of A1120 for human RBP4 and mouse RBP4 are 90nM and 66nM, respectively. In B6D2F1 mice, a hybrid F₁ strain between C57Bl/6 and DBA/2, single oral administration of 30mg/kg A1120 decreased serum levels of RBP4 and retinol with the peak reduction observed at 12 hours after treatment. In B6D2F1 mice fed a high-fat diet for 6 weeks, administration of A1120 (as a diet admixture at 30mg/kg) for additional 4 – 6 weeks did not affect glucose levels following the oral glucose challenge^[1].
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CAS号	1152782-19-8	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H19F3N2O3	运输	蓝冰
分子量	392.37	别名	2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

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