CAS No.: 1435934-25-0
A 419259 3HCl Catalog No. CSN17856
Synonyms: RK 20449 trihydrochloride;RK-20449 3HCl;A-419259 (hydrochloride)
A 419259 3HCl is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Pene-Dumitrescu T, Peterson LF, et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene. 2008 Nov 27;27(56):7055-69.
- [2] Wilson MB, Schreiner SJ, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1435934-25-0 | 储存条件 |
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| 分子式 | C29H37Cl3N6O | 运输 | 蓝冰 | |
| 分子量 | 592.00 | 别名 | RK 20449 trihydrochloride;RK-20449 3HCl;A-419259 (hydrochloride);RK-20449;A-419259 3HCl |
