CAS No.: 959122-11-3
A 922500 Catalog No. CSN12800
Synonyms: DGAT-1 Inhibitor 4a;(1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid
A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] King AJ, Segreti JA, et al. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur J Pharmacol. 2010 Jul 10;637(1-3):155-61.
- [2] Zhao G, Souers AJ, et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem. 2008 Feb 14;51(3):380-3.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 959122-11-3 | 储存条件 |
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| 分子式 | C26H24N2O4 | 运输 | 蓝冰 | |||||||
| 分子量 | 428.48 | 别名 | DGAT-1 Inhibitor 4a;(1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid | |||||||
| 溶解度 |
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动物实验配方 |
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