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CAS No.: 171869-93-5

α-MSH TFA Catalog No. CSN24285

Synonyms: α-Melanocyte-Stimulating Hormone TFA;α-Melanotropin (swine) trifluoroacetate (salt);α-melanocyte stimulating hormone (swine) trifluoroacetate

α-MSH is endogenous agonist of melanocortin receptor with Ki values of 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively.

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技术信息

生物活性

描述α-MSH (swine) trifluoroacetate (α-melanocyte stimulating hormone) is a pleiotropic neuropeptide and its renoprotective effects have been demonstrated in models of acute kidney injury. α-MSH treatment reduced urine flow and impaired recovery of glomerular filtration rate (GFR) compared to controls. After each dose of α-MSH, a trend towards reduced mean arterial blood pressure and increased heart rate was observed. α-MSH did not affect expression of inflammatory markers. α-MSH impaired recovery of renal function in the first ten hours following DBD (deceased brain dead) kidney transplantation possibly due to hemodynamic changes^[1]. alpha-melanocyte stimulating hormone analogue AP214 can protect against acute kidney injury in higher vertebrates^[2].
参考文献

[1] van Rijt WG, Secher N, Keller AK, et al. α-Melanocyte stimulating hormone treatment in pigs does not improve early graft function in kidney transplants from brain dead donors. PLoS One. 2014;9(4):e94609. Published 2014 Apr 11
[2] Simmons MN, Subramanian V, Crouzet S, et al. Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model [published correction appears in J Urol. 2010 Jul;184(1):398. Neilsen, Søren [corrected to Nielsen, Søren]]. J Urol. 2010;183(4):1625‐1629

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.5621 mL
- 2.8107 mL
- 5.6214 mL
- 5 mM
- 0.1124 mL
- 0.5621 mL
- 1.1243 mL
- 10 mM
- 0.0562 mL
- 0.2811 mL
- 0.5621 mL

技术信息

CAS号	171869-93-5	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C79H110F3N21O21S	运输	蓝冰
分子量	1778.91	别名	α-Melanocyte-Stimulating Hormone TFA;α-Melanotropin (swine) trifluoroacetate (salt);α-melanocyte stimulating hormone (swine) trifluoroacetate;α-MSH (human;mouse;rat;porcine;bovine;ovine) (trifluoroacetate salt);α-Melanocyte-stimulating Hormone;Ac-SYSMEHFRWGKPV-NH2

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