CAS No.: 450839-40-4
ABT-100 Catalog No. CSN26789
Synonyms: A-367074
ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 450839-40-4 | 储存条件 |
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| 分子式 | C27H19F3N4O3 | 运输 | 蓝冰 | |
| 分子量 | 504.46 | 别名 | A-367074 |
