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CAS No.: 587870-77-7

ABT-724 3HCl/ABT 724 三盐酸盐 Catalog No. CSN25293

Synonyms: ABT-724 (hydrochloride);ABT-724 (HCl)

ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.

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技术信息

生物活性

描述ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. It is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. It also could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an effect that is blocked by haloperidol and clozapine but not by domperidone. ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats^[1]. ABT-724 (0.16 and 0.64mg/kg) treatment alleviated hyperactivity and spatial learning impairment in SHRs(spontaneously hypertensive rats) ^[2].
参考文献

[1] Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, Donnelly-Roberts DL, Nakane M, Lynch JJ 3rd, Kolasa T, Polakowski JS, Osinski MA, Marsh K, Andersson KE, Sullivan JP. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63
[2] Yin P, Cao AH, Yu L, Guo LJ, Sun RP, Lei GF. ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Neurosci Lett. 2014 Sep 19;580:142-6

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4829 mL
- 12.4147 mL
- 24.8294 mL
- 5 mM
- 0.4966 mL
- 2.4829 mL
- 4.9659 mL
- 10 mM
- 0.2483 mL
- 1.2415 mL
- 2.4829 mL

技术信息

CAS号	587870-77-7	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H22Cl3N5	运输	蓝冰
分子量	402.75	别名	ABT-724 (hydrochloride);ABT-724 (HCl)

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ABT-724 3HCl/ABT 724 三盐酸盐 Catalog No. CSN25293

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