|乙酰氧肟酸|CsnPharm

CAS No.: 546-88-3

Acetohydroxamic acid/乙酰氧肟酸 Catalog No. CSN12766

Synonyms: AHA;N-Hydroxyacetamide;Methylhydroxamic Acid

Acetohydroxamic Acid is a synthetic drug derived from hydroxylamine and ethyl acetate with similar structure with urea, acting as an antagonist of the bacterial enzyme urease.

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技术信息

生物活性

描述Acetohydroxamic acid (acetH) is a bacterial urease inhibitor drug used to treat kidney stones and infections in the urinary tract, and hydroxyurea (HU) is a drug used for antineoplasm and sickle cell diseases. Both acetH and HU are hydroxamic acid derivatives. Regarding radical scavenging activities, the half-inhibition concentrations (IC50) of acetH against α,α-diphenyl-β-picrylhydrazyl radical and hydroxyl radical were 34.86 and 104.42 μM, respectively. The IC50 of acetH against semicarbazide-sensitive amine oxidase was 10.56 μM, and acetH showed noncompetitive inhibition respective to the substrates (benzylamine)^[2]. Acetohydroxamic acid at a concentration of 1μM, 60 μM, and 1 mM inhibited urease of intact rumen microbes in vitro by 11%, 50%, and 74%. Acetohydroxamic acid at a concentration that produced 50% urease inhibition did not affect rumen cellulase and proteolytic enzymes in vitro^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03181828	Urea Cycle Disorder	Phase 1 Phase 2	Active, not recruiting	April 30, 2019	United States, District of Col... more >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 Collapse <<
NCT02670889	Ornithine Transcarbamylase Def... more >>iciency Argininosuccinate Synthetase Deficiency (Citrullinemia) Argininosuccinic Acid Lyase Deficiency (Argininosuccinic Aciduria) Carbamyl-Phosphate Synthase I Deficiency Collapse <<	Phase 1 Phase 2	Not yet recruiting	March 2019	-

参考文献

[1] Star RA, Gillin AD, et al. The urease inhibitor acetohydroxamic acid is transported by the urea pathway in rat terminal IMCD. Am J Physiol. 1993 Sep;265(3 Pt 2):F385-90.
[2] Liu YH, Lu YL, Liu DZ, Hou WC. Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro. Drug Des Devel Ther. 2017;11:2139–2147.
[3] Makkar HP, Sharma OP, Dawra RK, Negi SS. Effect of acetohydroxamic acid on rumen urease activity in vitro. J Dairy Sci. 1981;64(4):643–648

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 13.3215 mL
- 66.6075 mL
- 133.2150 mL
- 5 mM
- 2.6643 mL
- 13.3215 mL
- 26.6430 mL
- 10 mM
- 1.3322 mL
- 6.6608 mL
- 13.3215 mL

技术信息

CAS号

546-88-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C2H5NO2

运输

蓝冰

分子量

75.07

别名

AHA;N-Hydroxyacetamide;Methylhydroxamic Acid;Lithostat;Acetohydroxamic Acid;NSC 5073;NSC 408425;NSC-176136;乙酰氧肟酸

溶解度

DMSO	15.0 mg/mL (199.8 mM)
Ethanol	15.0 mg/mL (199.8 mM)

动物实验配方

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Acetohydroxamic acid/乙酰氧肟酸 Catalog No. CSN12766

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