|(1R,2R,4S)-4-(((2R,4S,5S,6S)-4-(二甲氨基)-5-(((2S,4S,5S,6S)-4-羟基-6-甲基-5-(((2R,6S)-6-甲基-5-氧代四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-6-甲基四氢-2H-吡喃-2-基)氧基)-2-乙基-2,5,7-三羟基-6,11-二氧代-1,2,3,4,6,11-六氢并四苯-1-甲酸甲酯盐酸盐|CsnPharm

CAS No.: 75443-99-1

Aclacinomycin A HCl/盐酸阿柔比星 Catalog No. CSN20399

Synonyms: Aclarubicin hydrochloride;Aclacinomycin;Antibiotic MA144A1. Aclacin

Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.

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描述Aclarubicin hydrochloride is the hydrochloride salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03026842	Acute Myeloid Leukemia	Phase 4	Active, not recruiting	October 2024	China, Jilin ... more >> First Hospital of Jilin University Changchun, Jilin, China, 130021 Collapse <<
NCT02886559	AML Relapse	Phase 1 Phase 2	Recruiting	June 2019	China ... more >> China PLA General Hospital Recruiting Beijing, China, 100039 Contact: Li Yu, M.D Ph.D 010-66937644 chunhuiliyu@yahoo.com Principal Investigator: Li-Xin Yu Collapse <<
NCT03560908	Relapsed AML ... more >>T(8;21) C-KIT Mutation Collapse <<	Phase 1	Recruiting	December 31, 2020	China, Tianjin ... more >> HBDH Recruiting Tianjin, Tianjin, China, 300020 Contact: Hui Wei Collapse <<

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参考文献

[1] Matsuno S, Hisano H, et al. Growth-inhibitory effect of combination chemotherapy for human pancreatic cancer cell lines. Cancer. 1990 Dec 1;66(11):2369-74.
[2] Ichihara T, Sakamoto K, et al. Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. Cancer Res. 1989 Aug 1;49(15):4357-62.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1788 mL
- 5.8939 mL
- 11.7879 mL
- 5 mM
- 0.2358 mL
- 1.1788 mL
- 2.3576 mL
- 10 mM
- 0.1179 mL
- 0.5894 mL
- 1.1788 mL

技术信息

CAS号	75443-99-1	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C42H54ClNO15	运输	蓝冰
分子量	848.33	别名	Aclarubicin hydrochloride;Aclacinomycin;Antibiotic MA144A1. Aclacin;Aclacinomycine;Aclacinon;Aclaplastin;Jaclacin. ACM;ACMA. MA144A1

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03026842	Acute Myeloid Leukemia	Phase 4	Active, not recruiting	October 2024	China, Jilin ... more >> First Hospital of Jilin University Changchun, Jilin, China, 130021 Collapse <<
NCT02886559	AML Relapse	Phase 1 Phase 2	Recruiting	June 2019	China ... more >> China PLA General Hospital Recruiting Beijing, China, 100039 Contact: Li Yu, M.D Ph.D 010-66937644 chunhuiliyu@yahoo.com Principal Investigator: Li-Xin Yu Collapse <<
NCT03560908	Relapsed AML ... more >>T(8;21) C-KIT Mutation Collapse <<	Phase 1	Recruiting	December 31, 2020	China, Tianjin ... more >> HBDH Recruiting Tianjin, Tianjin, China, 300020 Contact: Hui Wei Collapse <<
NCT02432911	Acute Myeloid Leukemia	Not Applicable	Recruiting	May 2021	China, Tianjin ... more >> Treatment and Diagnosis Center of Leukemia Recruiting Tianjin, Tianjin, China, 300020 Contact: Jianxiang Wang, MD +862223909120 wangjx@medmail.com.cn Contact: Chunlin Zhou, MD +8613820429085 zcl7317@sina.com Collapse <<
NCT03045627	Acute Myeloid Leukemia	Phase 2	Recruiting	July 2020	China, Shandong ... more >> Qilu hospital, Shandong University Recruiting Jinan, Shandong, China, 250012 Contact: Ming Hou houming@medmail.com.cn Principal Investigator: Ming Hou Collapse <<
NCT02723448	Vasculopathy, Retinal, With Ce... more >>rebral Leukodystrophy Cerebroretinal Vasculopathy, Hereditary Collapse <<	Phase 1	Active, not recruiting	March 2019	United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse <<
NCT03181815	Acute Myeloid Leukemia ... more >> Relapse Leukemia Collapse <<	Phase 2	Recruiting	May 1, 2019	China, Guangdong ... more >> Liang Wang Recruiting Guangzhou, Guangdong, China, 510060 Contact: Liang Wang, M.D. +862087342439 wangliang@sysucc.org.cn Collapse <<
NCT02432911	Acute Myeloid Leukemia	Not Applicable	Recruiting	May 2021	China, Tianjin ... more >> Treatment and Diagnosis Center of Leukemia Recruiting Tianjin, Tianjin, China, 300020 Contact: Jianxiang Wang, MD +862223909120 wangjx@medmail.com.cn Contact: Chunlin Zhou, MD +8613820429085 zcl7317@sina.com Collapse <<
NCT03560908	Relapsed AML ... more >>T(8;21) C-KIT Mutation Collapse <<	Phase 1	Recruiting	December 31, 2020	China, Tianjin ... more >> HBDH Recruiting Tianjin, Tianjin, China, 300020 Contact: Hui Wei Collapse <<
NCT03181815	Acute Myeloid Leukemia ... more >> Relapse Leukemia Collapse <<	Phase 2	Recruiting	May 1, 2019	China, Guangdong ... more >> Liang Wang Recruiting Guangzhou, Guangdong, China, 510060 Contact: Liang Wang, M.D. +862087342439 wangliang@sysucc.org.cn Collapse <<
NCT02886559	AML Relapse	Phase 1 Phase 2	Recruiting	June 2019	China ... more >> China PLA General Hospital Recruiting Beijing, China, 100039 Contact: Li Yu, M.D Ph.D 010-66937644 chunhuiliyu@yahoo.com Principal Investigator: Li-Xin Yu Collapse <<
NCT03026842	Acute Myeloid Leukemia	Phase 4	Active, not recruiting	October 2024	China, Jilin ... more >> First Hospital of Jilin University Changchun, Jilin, China, 130021 Collapse <<
NCT02723448	Vasculopathy, Retinal, With Ce... more >>rebral Leukodystrophy Cerebroretinal Vasculopathy, Hereditary Collapse <<	Phase 1	Active, not recruiting	March 2019	United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse <<
NCT03045627	Acute Myeloid Leukemia	Phase 2	Recruiting	July 2020	China, Shandong ... more >> Qilu hospital, Shandong University Recruiting Jinan, Shandong, China, 250012 Contact: Ming Hou houming@medmail.com.cn Principal Investigator: Ming Hou Collapse <<

Aclacinomycin A HCl/盐酸阿柔比星 Catalog No. CSN20399

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