|N6-[4-[[[4-[[[(2-氨基乙基)氨基]羰基]甲基]-苯胺]羰基]甲基]苯基]腺苷酸|CsnPharm

CAS No.: 96760-69-9

Adenosine amine congener/腺苷胺同类物 Catalog No. CSN25244

Synonyms: ADAC;6-Adac

Adenosine amine congener hydrate is a potent aqueous-soluble A1 adenosine receptor agonist with Ki value of 0.85nM for binding against [3H]N6-cyclohexyladenosine in rat cerebral cortex membranes.

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技术信息

生物活性

描述Adenosine amine congener (ADAC), a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. ADAC was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner^[1]. ADAC was administered intraperitoneally (100 mg/kg/day) at time intervals after noise exposure. Hearing thresholds were assessed using auditory brainstem responses and the hair cell loss was evaluated by quantitative histology^[2]. Chronic treatment with low microgram doses of ADAC (25-100 mg/kg) protects against both mortality and neuronal damage induced by 10 min bilateral carotid occlusion in gerbils. Acute preischemic administration of the drug at 75-200 mg/kg also results in a statistically significant reduction of postischemic mortality and morbidity^[3]. Administration of ADAC at 100 mg/kg in non-ischemic animals did not result in bradycardia, hypotension, or hypothermia. When ADAC is used postischemically, the most optimal level of protection is obtained when drugs are given at 30 min to 6 h after the insult^[4].
参考文献

[1] Vlajkovic SM, Chang H, Paek SY, Chi HH, Sreebhavan S, Telang RS, Tingle M, Housley GD, Thorne PR. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489
[2] Vlajkovic SM, Lee KH, Wong AC, Guo CX, Gupta R, Housley GD, Thorne PR. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81
[3] Von Lubitz DK, Lin RC, Bischofberger N, Beenhakker M, Boyd M, Lipartowska R, Jacobson KA. Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. Eur J Pharmacol. 1999 Mar 26;369(3):313-7
[4] Von Lubitz DK, Lin RC, Paul IA, Beenhakker M, Boyd M, Bischofberger N, Jacobson KA. Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. Eur J Pharmacol. 1996 Dec 5;316(2-3):171-9

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7343 mL
- 8.6715 mL
- 17.3429 mL
- 5 mM
- 0.3469 mL
- 1.7343 mL
- 3.4686 mL
- 10 mM
- 0.1734 mL
- 0.8671 mL
- 1.7343 mL

技术信息

CAS号	96760-69-9	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C28H32N8O6	运输	蓝冰
分子量	576.60	别名	ADAC;6-Adac

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Adenosine amine congener/腺苷胺同类物 Catalog No. CSN25244

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