CAS No.: 850173-95-4
ADL-5859 盐酸盐 Catalog No. CSN12425
Synonyms: ADL5859 (hydrochloride)
ADL-5859 HCl is both a δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM) and selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel with IC50 value of 78 µM.
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400-920-2911
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00603265 Peripheral Neuropathy ... more >> Neuropathic Pain Collapse << Phase 2 Completed - - NCT00603265 - - Completed - - - 参考文献
- [1] Nozaki C, Le Bourdonnec B, et al. δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization. J Pharmacol Exp Ther. 2012 Sep;342(3):799-807.
- [2] Le Bourdonnec B, Windh RT, et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine] -4-yl)benzamide (ADL5859). J Med Chem. 2008 Oct 9;51(19):5893-6.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 850173-95-4 | 储存条件 |
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| 分子式 | C24H29ClN2O3 | 运输 | 蓝冰 | |||||||||
| 分子量 | 428.95 | 别名 | ADL5859 (hydrochloride) | |||||||||
| 溶解度 |
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动物实验配方 |
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