|6-氨基-2-(氟甲基)-3-(邻甲苯基)喹唑啉-4(3H)-酮|CsnPharm

CAS No.: 56287-74-2

Afloqualone/氟喹酮 Catalog No. CSN10227

Synonyms: HQ-495;氟喹酮

Afloqualone is an agonist of GABA receptor and has muscle-relaxant effects.

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生物活性

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技术信息

生物活性

描述Afloqualone is an oral muscle relaxant and evokes ultraviolet A-induced photosensitivity dermatitis as a side effect^[2]. Afloqualone dose dependently inhibited both (mono-) MSR and PSR (poly-synaptic reflex) potentials in spinalized cats though afloqualone had no inhibitory effect on the patellar reflex in cats as reported in the previous paper. In rats and cats, afloqualone dose dependently relaxed both alpha- and gamma-rigidity when administered p.o. as well as i.v. Its 50% inhibitory dose for alpha-rigidity was 1.5-2 times larger than that for gamma-rigidity^[3]. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site^[4]. Eperisone and afloqualone act by relaxing both skeletal and vascular smooth muscles to improve circulation and suppress pain reflex^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5298 mL
- 17.6491 mL
- 35.2982 mL
- 5 mM
- 0.7060 mL
- 3.5298 mL
- 7.0596 mL
- 10 mM
- 0.3530 mL
- 1.7649 mL
- 3.5298 mL

技术信息

CAS号

56287-74-2

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14FN3O

运输

蓝冰

分子量

283.30

别名

HQ-495;氟喹酮

溶解度

DMSO	55.0 mg/mL (194.1 mM)
Water	Insoluble
Ethanol	27.0 mg/mL (95.3 mM)

动物实验配方

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Afloqualone/氟喹酮 Catalog No. CSN10227

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